Linrui Gao

Secretory leukocyte peptidase inhibitor as a dynamic radiotherapy response biomarker in esophageal squamous cell carcinoma

Hongming Deng, Junyi Li, Linrui Gao, Ning Huang et autres

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VIRMA/IGF2BP3-mediated ANLN upregulation promotes intrahepatic cholangiocarcinoma growth by forming a positive feedback loop with RhoA/YAP1/TEAD1 signaling pathway

J. Jillian Zhang, Ning Huang, Linrui Gao, Ai Guo et autres

The prognosis of patients with intrahepatic cholangiocarcinoma (ICC) remains poor owing to the lack of effective targeted therapeutic strategies. Thus, the exploration of the molecular pathogenesis of ICC is urgently required. The cytoskeleton protein, anillin (ANLN), has been reported to contribute to …

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Identification of Oral Microbiome Biomarkers Associated with Lung Cancer Diagnosis and Radiotherapy Response Prediction

Xiaoqian Shi, Nan Bi, Wenyang Liu, Liying Ma et autres

The oral cavity acts as the anatomical gateway to the respiratory tract, sharing both microbiological and pathophysiological links with the lower airways. Although radiotherapy is a cornerstone treatment for lung cancer, reliable oral microbiome biomarkers for predicting patient outcomes remain lacking. We …

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IL-15 signaling via cis- and trans-presentation to progenitor-exhausted CD8+ T cells enhances radio-immunotherapy efficacy in ESCC

Yi You, Linrui Gao, Shijia Li, Hui Huang et autres

BACKGROUND: Concurrent chemoradiotherapy (CRT) combined with PD-1/PD-L1 targeting immunotherapy (IM) has emerged as a promising treatment for locally advanced esophageal squamous cell carcinoma (ESCC). However, individual responses to this treatment vary, highlighting the need for predictive biomarkers to improve therapeutic efficacy. Interleukin-15 …

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Simultaneous integrated boost intensity‐modulated radiotherapy with or without concurrent chemotherapy in patients with esophageal squamous cell carcinoma: A multicenter, open‐label, randomized, phase III clinical trial

Weiming Han, Linrui Gao, Xiaomin Wang, Chen Li et autres

This multicenter, randomized phase III clinical trial assesses the efficacy and toxicity of SIB-RT with/without concurrent chemotherapy in patients with inoperable esophageal squamous cell carcinoma (ESCC) in the era of intensity-modulated RT and was conducted between December 2017 and November 2020. Patients …

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Identification of Oral Microbiome Biomarkers Associated with Lung Cancer Diagnosis and Radiotherapy Response Prediction

Xiaoqian Shi, Wenyang Liu, Liying Ma, Mingyang Liu et autres

cn (code pays fourni par la source)

A nomogram for predicting the risk of chemoradiotherapy-associated thrombocytopenia in patients with esophageal cancer: a real-world cohort study

Jia-Xuan Yang, Siyu Zuo, Jie Yang, Linrui Gao et autres

Background: Thrombocytopenia is a common hematological toxicity in esophageal cancer (EC) patients receiving radiation therapy. Objectives: The purpose of this study was to construct and validate a nomogram for predicting the incidence of thrombocytopenia in EC patients receiving radiotherapy. Design: A retrospective …

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Mechanism Study on the Preventive Effect of ELITEA Compound Tea on Hyperuricemia in Rats Based on Serum Untargeted Metabolomics

Shulian Liu, Yongliang Zhu, Xianghan Zhang, Linrui Gao et autres

Background/Objectives: Hyperuricemia (HUA) has become the second largest metabolic disease after diabetes, and has become a major public health problem. The ELITEA compound tea extract can effectively reduce the serum uric acid level in HUA rat models. In this study, the mechanism …

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Adebrelimab plus chemotherapy as neoadjuvant therapy for locally advanced esophageal squamous cell carcinoma (ESCC): a single-center, phase II, single-arm, open-label clinical trial (ADENEO) protocol

Peng Tang, Linrui Gao, Siyu Zuo, Ke Zhang et autres

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Low-dose moderate hypofractionated radiotherapy for indolent non-Hodgkin lymphoma: a multicentre, single-arm, phase 2 trial

Xinyue Wang, Ximei Zhang, Liang Wang, Linrui Gao et autres

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Initial Results of the Multicenter Phase II Trial of a Novel Hypofractionated Low-Dose Radiotherapy for Indolent Non-Hodgkin Lymphoma

X. Wang, Linrui Gao, L. Wang, Xiaoer Zhang et autres

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Personalized Minimal Residual Disease Profiling Predicts Prognosis in Esophageal Carcinoma Undergoing Definitive Radiotherapy

Linrui Gao, Peng Yue, Zhijie Zhou, Zhangang Xiao et autres