Jiajia Yao

Proteomic and metabolomic alterations in follicular fluid associated with embryological outcomes in women with isolated ANA-positive infertility: a prospective multi-omics cohort study

Kai Ding, Wei Jiang, Yidan Chen, Shanren Cao et autres

Autoimmune abnormalities are increasingly recognized as contributing factors to unexplained infertility. Among these, antinuclear antibodies (ANAs) are the most frequently detected autoantibodies and have been associated with adverse embryologic outcomes. However, the mechanisms by which isolated ANA positivity (defined as ANA positivity …

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Satralizumab in the management of aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder during pregnancy: a case report

Man Ding, Bo Yin, Jiajia Yao, Ying Liu et autres

We report the case of a 25-year-old pregnant woman who was diagnosed with aquaporin-4 antibody-positive (AQP4+) neuromyelitis optica spectrum disorder (NMOSD) at 19 weeks of gestation. During the acute stage of the disease, she was treated with high-dose prednisone pulse therapy. Beginning …

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Paroxysmal Kinesigenic Dyskinesia With Infantile Convulsions in a Child With Inherited Co-deletion of 16p11.2 and 16p12.2: A Case Report and Literature Review

Man Ding, Bo Yin, Yin Liu, Jiajia Yao et autres

16p11.2 deletion syndrome is a group disorder associated with intellectual impairment, developmental delay, and autism spectrum disorder (ASD). Paroxysmal kinesigenic dyskinesia with infantile convulsions (PKD/IC) is an extremely rare condition. A 6-year-old Chinese boy presented with a two-month history of involuntary dystonic …

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37P Efficacy and safety of fruquintinib vs placebo by metastatic site in metastatic colorectal cancer: A FRESCO-2 subgroup analysis

R. Garcia-Carbonero, N. Arvind Dasari, C. Eng, E. Elez Fernandez et autres

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Experimental Autoimmune Neuritis Nerve Demyelination Is Attenuated by Blocking JAK2/STAT3 Signaling Pathway in Rats

Rumeng Zhou, Shuping Liu, Yue Liu, Yin Liu et autres

BACKGROUND: Guillain‒Barré syndrome (GBS) is an immune-mediated peripheral neuropathy in which inflammatory cells and cytokines participate. The JAK-STAT signaling pathway is a major pathway involved in cytokine signal transduction, but the role of this pathway in GBS is not clear. AG490 is …

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Quality-adjusted survival in patients with metastatic colorectal cancer treated with fruquintinib plus best supportive care: results from FRESCO-2

Sebastian Stintzing, Josep M. Tabernero, Arvind N. Dasari, Sara Lonardi et autres

BACKGROUND: Treatment toxicity and disease-related symptoms of metastatic colorectal cancer (mCRC) can adversely affect quality of life (QoL). Maintaining QoL is an important treatment goal alongside improving survival outcomes. Quality-adjusted time without symptoms of disease or toxicity (Q-TWiST) measures the quality of …

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Synergistic effect of anemia and obstructive sleep apnea on hypertension: National Health and Nutrition Examination Survey 2015–2018

Jiajia Yao, Xi C. He, Han Wang, Anzi Wang et autres

OBJECTIVE: Anemia, obstructive sleep apnea (OSA), and hypertension are common social health problems. They are interconnected. This study assessed the independent association of anemia and OSA with hypertension and the interaction between anemia and OSA on hypertension in the US population. METHODS: …

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Predicting of Mechanical Ventilation and Outcomes by Using Models and Biomarker in Guillain-Barré Syndrome

Jiajia Yao, Rumeng Zhou, Yue Liu, Yin Liu et autres

BACKGROUND: Guillain-Barré syndrome (GBS) is an acute inflammatory neuropathy. The Erasmus GBS Respiratory Insufficiency Score (EGRIS) and the modified Erasmus GBS Outcome Score (mEGOS) are prognostic models used in the prediction of mechanical ventilation and outcome. Thus far, there are only few …

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E59 Deforming juvenile idiopathic arthritis: a case report in Bouake (Cote D’ivoire)

Aissata Doucoure Traore, Ehaulier Soh Christian Louis Kouakou, Jiajia Yao, E Koffi et autres

Abstract Introduction Juvenile Idiopathic Arthritis (JIA) is a group of conditions characterized by chronic inflammatory joint disease of unknown aetiology before the age of 16. This joint damage is complicated by joint deformities, amplitude limitations, muscle imbalances causing a reduction in the …

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MicroRNA-23a-3p Is Upregulated in Plasma Exosomes of Bulbar-onset ALS Patients and Targets ERBB4

Yue Liu, Man Ding, Sijia Pan, Rumeng Zhou et autres

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease related to the progressive death of motor neurons. Understanding the pathogenesis of ALS continues to provide considerable challenges. Bulbar-onset ALS involves faster functional loss and shorter survival time than spinal cord-onset ALS. However, debate …

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Progress in Guillain–Barré syndrome immunotherapy—A narrative review of new strategies in recent years

Jiajia Yao, Rumeng Zhou, Yue Liu, Zuneng Lu

Guillain - Barré syndrome (GBS) is an immune-mediated neuropathy, the pathology of which is not clear. Both cellular and humoral immunity are involved in the occurrence of the disease, and molecular mimicry is currently the most widely recognized pathogenesis. Intravenous immunoglobulin (IVIg) …

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Clinical Features and Differences of Miller Fisher Syndrome in Southern China: Retrospective Analysis of 72 Patients in 13 Provinces of Southern China

Hang Yu, Man Ding, Qian Cao, Rumeng Zhou et autres

Background and PurposeWe aimed to determine the clinical features of Miller Fisher syndrome (MFS) in southern China and compare them with those presenting in other countries. MethodsWe collected the medical records of patients diagnosed with MFS during 2013-2016.We analyzed the age, sex, …

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