Lu Cheng

Schisandrin B inhibits hepatic inflammation and steatosis via activation of pregnane X receptor signaling in methionine and choline-deficient high fat diet-induced steatohepatitis mouse model

Chun Yu Gu, Li Shan Yan, Lu Cheng, Zhi Shan Huang et autres

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The metabolic landscape of connective tissue diseases: Applications and discoveries in metabolomics research

Yinlan Wu, Daihua Deng, Yanhong Li, Sijun Zhang et autres

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Modulation of gut microbiota, up-regulation of ZO-1, and promotion of metabolism as therapeutic mechanisms of indole-3-carbinol against obesity in mice

Guliruoyi Paerhati, Yuche Wu, Lu Cheng

Background Indole-3-carbinol (I3C) is a compound derived from Cruciferous vegetables. We aim to ascertain whether I3C mediates the relations between mouse gut microbiota, intestinal barrier function, and metabolism to treat obesity in mice. Methods The experimental analyses focused on the changes in …

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Potential prebiotic properties and proliferation mechanism of fermented milk-derived polypeptides

Lu Cheng, Feng Wang, Yuqiao Guo, Qiwei Du et autres

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Daphnetin Ameliorates Neuropathic Pain via Regulation of Microglial Responses and Glycerophospholipid Metabolism in the Spinal Cord

Wulin Liang, Tian‐Rui Zhang, Mingqian Zhang, Jiahui Gao et autres

Neuropathic pain (NP) is a common type of chronic pain caused by a lesion or disease of the somatosensory nervous system. This condition imposes a considerable economic burden on society and patients. Daphnetin (DAP) is a natural product isolated from a Chinese …

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Potential Prebiotic Properties and Proliferation Mechanism of Fermented Milk-Derived Polypeptides

Lu Cheng, Feng Wang, Yuqiao Guo, Qiwei Du et autres

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Sources, Processing-Related Transformation, and Gut Axis Regulation of Conventional and Potential Prebiotics

Lu Cheng, Lingyu Kong, Chaoran Xia, Xiaoqun Zeng et autres

One strategy to achieve a balanced intestinal microbiota is to introduce prebiotics. Some substances present in the diet, such as soybean extracts, koji glycosylceramides, grape extracts, tea polyphenols, and seaweed extracts, can be considered as potential prebiotics, because they can selectively stimulate …

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iTRAQ‐based quantitative proteomic analysis of the effect of heat shock on freeze‐drying of Lactobacillus acidophilus ATCC4356

Mingxue Liu, Xiaoqun Zeng, Yating He, Chaoran Xia et autres

Summary In order to investigate the mechanism by which heat shock improves the survival rate of lactic acid bacteria (LAB) following lyophilisation, we performed proteomic analysis based on isobaric tags for relative and absolute quantitation (iTRAQ) on Lactobacillus acidophilus (LA) ATCC4356. Among …

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NMR‐based metabolomics profiling of no‐added‐nitrite Chinese bacon (unsmoked) during processing

Ling Huang, Xiaoqun Zeng, Yangfang Ye, Lu Cheng et autres

H-NMR and multivariate data analysis. The results showed that 21 metabolites were dominant during processing, which involved marinating, air-drying, fermentation, and baking, including amino acids, sugars, organic acids, nucleic acids and their derivatives, and alkaloids. The contents of isoleucine, leucine, valine, alanine, …

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WITHDRAWN: Down-regulation of TIPE2 expression in peripheral blood mononuclear cells from patients with asthma in childhood

Shifu Wang, Guangxin Wang, Hua-feng Yu, Su-Lan Wang et autres

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Active efflux of bile salts by Escherichia coli

David G. Thanassi, Lu Cheng, Hiroshi Nikaido

Enteric bacteria such as Escherichia coli must tolerate high levels of bile salts, powerful detergents that disrupt biological membranes. The outer membrane barrier of gram-negative bacteria plays an important role in this resistance, but ultimately it can only retard the influx of …

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