Renjie Jiao

A non-canonical bipartite NLS dictates nuclear import and function of the Drosophila Pc protein

Yu Fan, Yong Zeng, Jie Zhou, Renjie Jiao et autres

cn (code pays fourni par la source)

Functional characterization of Paillotin: an immune peptide regulated by the Immune deficiency (Imd) pathway with pathogen-specific roles in Drosophila immunity

Yao Tian, Xiaojing Yue, Renjie Jiao, Mark A. Hanson et autres

Insects, such as Drosophila melanogaster , rely on innate immune defences to combat microbial threats. Antimicrobial peptides (AMPs) play an important role in limiting pathogen entry and colonization. Despite intensive research into the regulation and biochemical properties of antimicrobial peptides, their exact …

ch, fr, cn, gb (code pays fourni par la source)

Human fecal microbiota transplantation attenuates high dietary oxalate-induced renal calcium oxalate crystal depositions in rats via repairing Allobaculum- related gut barrier damage

Yuhao Zhou, Min Lei, Wenwen Cai, Zhenglin Chang et autres

ABSTRACT High dietary oxalate (HDOx) diet is a key factor in kidney stone formation, with gut microbiota playing a significant role. Although several studies have indicated that fecal microbiota transplantation from healthy animals can effectively reduce renal calcium oxalate (CaOx) depositions in …

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Gut microbiota-regulated unconjugated bilirubin metabolism drives renal calcium oxalate crystal deposition

Shujue Li, Wenzheng Wu, Yuhao Zhou, Shike Zhang et autres

Gut microbial dysbiosis and the resultant metabolic disorder are intimately associated with calcium oxalate (CaOx) stone formation. Renal CaOx crystal deposition is one of the primary initiating factors of CaOx formation; however, the critical signaling metabolites communicating along the gut-kidney axis, and …

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Xgr is involved in body size control in Drosophila through promoting glucose uptake in the Malpighian tubules

Zhiwei Lin, Zihao He, Jianfeng Guo, Xiaofang Ji et autres

Body size control is fundamental to development and requires proper energy engagement. One of the key energy sensing factors is AMP-activated protein kinase (AMPK), which regulates glucose uptake to ensure ATP production and nutrition supply during development. Here, we identify that the …

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Exploring innate immunity through the lens of fruit fly models

Di Chen, Hua Cai, Renjie Jiao, Jean‐Luc Imler et autres

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Functional Characterization of Paillotin: An Immune Peptide Regulated by the Imd Pathway with Pathogen-Specific Roles in Drosophila Immunity

Yao Tian, Xiaojing Yue, Renjie Jiao, Mark A. Hanson et autres

Abstract Insects, such as Drosophila melanogaster, rely on innate immune defenses to combat microbial threats. Antimicrobial peptides (AMPs) play an important role in limiting pathogen entry and colonization. Despite intensive research into the regulation and biochemical properties of AMPs, their exact significance …

ch, fr, cn, gb (code pays fourni par la source)

The virus-induced cyclic dinucleotide 2′3′-c-di-GMP mediates STING-dependent antiviral immunity in Drosophila

Hua Cai, Lihua Li, Kailey M. Slavik, Jingxian Huang et autres

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ATG4B antagonizes antiviral immunity by GABARAP-directed autophagic degradation of TBK1

Weihong Xie, Chenqiu Zhang, Zheyu Wang, Hui Chen et autres

TBK1 (TANK binding kinase 1) is an essential kinase of antiviral immunity, yet the regulatory mechanisms responsible for its stringent control via autophagy are not fully understood. Here, we identify the macroautophagy/autophagy-related cysteine protease ATG4B as a negative regulator of human antiviral …

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A novel virus-induced cyclic dinucleotide, 2′3′-c-di-GMP, mediates STING-dependent antiviral immunity in Drosophila

Hua Cai, Lihua Li, Kailey M. Slavik, Jingxian Huang et autres

Abstract In mammals, the enzyme cGAS senses the presence of cytosolic DNA and synthesizes the cyclic dinucleotide (CDN) 2′3′-cGAMP. This CDN binds to and activates the protein STING to trigger immunity. We recently discovered in the model organism Drosophila melanogaster two cGAS-like …

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Supplementary table 1 from The SWI/SNF Complex Protein Snr1 Is a Tumor Suppressor in Drosophila Imaginal Tissues

Gengqiang Xie, Han-Qing Chen, Dongyu Jia, Zhiqiang Shu et autres

Supplementary Table 1: The mRNA level changes of representative components or targets of JAK-STAT, JNK, and Notch signaling pathways in snr1-RNAi tumorous wing discs relative to control wildtype wing discs.

Supplementary file 1 from The SWI/SNF Complex Protein Snr1 Is a Tumor Suppressor in Drosophila Imaginal Tissues

Gengqiang Xie, Han-Qing Chen, Dongyu Jia, Zhiqiang Shu et autres

Supplementary file 1