Jiali Gong

Association of admission lactate dehydrogenase-to-albumin ratio with acute pancreatitis recurrence after first-episode hypertriglyceridemia-induced acute pancreatitis: A multicenter retrospective cohort study

Chao Wang, Xiaonan Qiu, Jiali Gong, Haimei Xu et autres

ObjectiveHypertriglyceridemia-induced acute pancreatitis (HTG-AP) has a high recurrence rate, and recurrent episodes may result in repeated hospitalizations and long-term pancreatic complications. Simple admission-based markers for recurrence stratification remain limited. This study examined whether admission lactate dehydrogenase-to-albumin ratio (LAR) was associated with recurrence …

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Preclinical Study of Radiolabeled LyP-1 for Detecting Sunitinib-induced Changes in the Tumor Microenvironment and Synergistic Antitumor Effects in Triple-negative Breast Cancer

Sisi Liao, Qinli Qi, Lifang Jin, Jiali Gong et autres

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Screening of Fungicides against Coffee Anthracnose

Yiwei Lu, Jiali Gong, Chunping He, Yanqiong Liang et autres

The indoor virulence of 15 fungicides against Colletotrichum spp. (coffee anthracnose pathogen) was evaluated using the mycelial growth rate method. The results showed that prochloraz, carbendazim, prochloraz-manganese chloride complex, azoxystrobin, and difenoconazole exhibited strong inhibitory effects on mycelial growth, with EC50 values …

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Applying machine learning to predict bowel preparation adequacy in elderly patients for colonoscopy: development and validation of a web-based prediction tool

Jianying Liu, Wei Jiang, Ying Yu, Jiali Gong et autres

BACKGROUND: Adequate bowel preparation is crucial for effective colonoscopy, especially in elderly patients who face a high risk of inadequate preparation. This study develops and validates a machine learning model to predict bowel preparation adequacy in elderly patients before colonoscopy. METHODS: The …

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Preclinical evaluation and preliminary clinical study of 68Ga-NODAGA-NM-01 for PET imaging of PD-L1 expression

Lingzhou Zhao, Jiali Gong, Sisi Liao, Wenhua Huang et autres

Abstract Background Programmed cell death 1/programmed death ligand-1 (PD-L1)-based immune checkpoint blockade is an effective treatment approach for non-small-cell lung cancer (NSCLC). However, immunohistochemistry does not accurately or dynamically reflect PD-L1 expression owing to its spatiotemporal heterogeneity. Herein, we assessed the feasibility …

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99m Tc-Labeled D-Type PTP as a Plectin-Targeting Single-Photon Emission Computed Tomography Probe for Hepatocellular Carcinoma Imaging

Jiali Gong, Meilin Zhu, Lingzhou Zhao, Taisong Wang et autres

Plectin, a scaffolding protein overexpressed in tumor cells, plays a significant role in hepatocellular carcinoma (HCC) proliferation, invasion, and migration. However, the use of L-type peptides for targeting plectin is hindered by their limited stability and retention. We designed a D-type plectin-targeting …

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Hybrid Cell Membrane‐Coated Nanoparticles for Synergizing Sonodynamic Therapy and Immunotherapy against Triple‐Negative Breast Cancer

Jiali Gong, Danling Cheng, Changcun Liu, Shan Wu et autres

Abstract Tumor immunotherapy represents a highly promising modality for the treatment of triple‐negative breast cancer (TNBC). Nevertheless, its therapeutic efficacy has been profoundly impacted by challenges such as low drug uptake, hypoxia, and immunosuppression. To address these problems, the study develops a …

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Preclinical evaluation and preliminary clinical study of 68 Ga-NODAGA-NM-01 for PET imaging of PD-L1 expression

Lingzhou Zhao, Jiali Gong, Sisi Liao, Wenhua Huang et autres

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Thoracic SMARCA4-deficient undifferentiated tumor

Jiapeng Jiang, Zhixin Chen, Jiali Gong, Na Han et autres

Thoracic SMARCA4-deficient undifferentiated tumor (SMARCA4-UT) is a recently described smoking-related malignancy. The pathogenesis of SMARCA4-UT is the mutational inactivation and loss of expression of a subunit encoding the mammalian switch/sucrose nonfermenting ATPase-dependent chromatin remodeling complex (which can be mobilized using adenosine triphosphate …

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First Report of Colletotrichum fructicola Causing Anthracnose on Peanut (Arachis hypogaea) in China

Jiali Gong, Donglei Sun, Nengfei Bian, Rongqi Wang et autres

causing peanut anthracnose in China. Thus, it is recommended to pay close attention and take necessary prevention and control measures against potential spread of peanut anthracnose in China. .

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Preparation of Manganese Dioxide Supercapacitors by Secondary Construction of Three-Dimensional Substrates and Ion Embedding

Yihan Shi, Ming Zhang, Junshan Zhao, Liu Zhang et autres

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[99mTc]Tc-Labeled Plectin-Targeting Peptide as a Novel SPECT Probe for Tumor Imaging

Jiali Gong, Lingzhou Zhao, Jiqin Yang, Meilin Zhu et autres

Certain receptors are often overexpressed during tumor occurrence and development and closely correlate with carcinogenesis. Owing to its overexpression on the cell membrane and cytoplasm of various tumors, plectin, which is involved in tumor proliferation, migration, and invasion, has been viewed as …

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