Javier Sánchez‐Nieves

Antibiofilm activity of cationic carbosilane BD132 dendron and its synergistic effect with amphotericin B against Candida spp.

Natalia Gómez-Casanova, José Luis Copa-Patiño, Rafael Gómez, Javier Sánchez‐Nieves et autres

The BD132 is a cationic carbosilane dendron containing peripheral ammonium groups, which impairs antimicrobial properties, and the chaperone 4-phenylbutyrate, with anti-inflammatory and antibacterial properties. Its in vitro activity was evaluated against biofilm formation and against established biofilms in Candida albicans and Nakaseomyces …

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Reusable and green approach to extract proteins with magnetic nanoparticles coated with carbosilane dendrimers: application to the recovery of whey proteins

David Rincón-Montón, Ester Hernández-Corroto, Rebeca Lozano-García, Jesús Cano et autres

The valorisation of industrial waste, such as whey from the dairy industry, offers a sustainable approach to reduce environmental impact while obtaining high value-added products. However, current protein extraction methods are often costly, prompting interest in innovative alternatives such as dendrimers and …

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Crossing Barriers: PEGylated Gold Nanoparticles as Promising Delivery Vehicles for siRNA Delivery in Alzheimer’s Disease

Elżbieta Okła, Marcin Hołota, Sylwia Michlewska, Serafin Zawadzki et autres

Background: The proportion of people suffering from neurodegenerative conditions, such as Alzheimer’s disease (AD), is increasing in the population year on year. Despite the constant effort of researchers, these conditions remain incurable and can only be managed by alleviation or delaying of …

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Antibacterial Creams Containing Cationic Carbosilane Dendrimers for Wound Treatment

Rebeca Lozano-García, Sara Quintana, Selma Benito‐Martínez, Guillermo Torrado et autres

High Resolution Image Download MS PowerPoint Slide Skin wounds are an important factor in developing bacterial infection, especially for chronic wounds. In this case, the exposure to long traditional antibacterial-based treatments can lead to the appearance of resistance to these drugs. This …

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Electrospun Nanofibers for the Delivery of Endolysin/Dendronized Ag-NPs Complex Against Pseudomonas aeruginosa

Magdalena Lasak, Małgorzata Łysek-Gładysińska, Karolina Lach, Viraj P. Nirwan et autres

Purpose: As bacterial resistance to antibiotics increases, there is an urgent need to identify alternative antibacterial agents and improve antibacterial materials. One is the controlled transport of antibacterial agents that prevents infection with drug-resistant bacteria, especially in the treatment of difficult-to-heal wounds. …

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First Dose of Cationic Dendrimers Determines the Development of Resistance or Sensitivity to Nanomaterials and Antibiotics Simultaneously in Pseudomonas Aeruginosa

Michał Detka, Karolina Lach, Óscar Barrios-Gumiel, Dorota Kuc‐Ciepluch et autres

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Amoebicidal and cysticidal in vitro activity of cationic dendritic molecules against Acanthamoeba polyphaga and Acanthamoeba griffini

Cristina Verdú-Expósito, Tania Martín‐Pérez, Jorge Pérez‐Serrano, Javier Sánchez‐Nieves et autres

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Pegylated gold nanoparticles interact with lipid bilayer and human serum albumin and transferrin

Elżbieta Okła, Sylwia Michlewska, Adam Buczkowski, Serafin Zawadzki et autres

Gold nanoparticles (AuNPs) are potentially applicable in drug/nucleic acid delivery systems. Low toxicity, high stability, and bioavailability are crucial for the therapeutic use of AuNPs and they are mainly determined by their interactions with proteins and lipids on their route to the …

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Endolysin CHAP domain-carbosilane metallodendrimer complexes with triple action on Gram-negative bacteria: Membrane destabilization, reactive oxygen species production and peptidoglycan degradation

Karolina Lach, Kinga Skrzyniarz, Samuel Takvor-Mena, Małgorzata Łysek-Gładysińska et autres

Bacterial resistance to antibiotics is a significant challenge that is associated with increased morbidity and mortality. Gram-negative bacteria are particularly problematic due to an outer membrane (OM). Current alternatives to antibiotics include antimicrobial peptides or proteins and multifunctional systems such as dendrimers. …

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Study of the antimicrobial activity of cationic carbosilane dendrimers against clinical strains of multidrug-resistant bacteria and their biofilms

Marcos Hernando-Gozalo, John Jairo Aguilera-Correa, Carlos Rescalvo-Casas, Laura Seijas‐Pereda et autres

Introduction Antimicrobial Resistance is a serious public health problem, which is aggravated by the ability of the microorganisms to form biofilms. Therefore, new therapeutic strategies need to be found, one of them being the use of cationic dendritic systems (dendrimers and dendrons). …

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Removing lead from water with carboxylate dendrimers and magnetic nanoparticles modified with carboxylate dendrimers

David Rincón-Montón, David Martínez-Salvador, Javier Sánchez‐Nieves, Rafael Gómez et autres

Abstract Contamination of water with heavy metals as lead (Pb2+) is a relevant problematic issue. In this work, we have tested different types of dendritic materials for lead removal from water and further recovery. The systems employed are magnetic nanoparticles (MNP) modified …

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Potential anti-adhesion activity of novel carbosilane zwitterionic dendrimers against eukaryotic and prokaryotic pathogenic microorganisms

Natalia Gómez-Casanova, Ángela Martín‐Serrano Ortiz, Irene Heredero‐Bermejo, Javier Sánchez‐Nieves et autres

The development of biofilms on different surfaces continues to be a major public health problem. The antimicrobial resistance and the difficulty of finding drugs capable of combating these established biofilms generates the urgent need to find compounds that prevent cells from settling …

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