Suvi E. Heinonen

Health and economic burden of herpes zoster in adults in Finland: A retrospective nationwide database study

Mari J. Kanerva, Suvi E. Heinonen, Tuukka Hakkarainen, Outi Isomeri et autres

The risk of herpes zoster (HZ) and its complications, such as postherpetic neuralgia (PHN), increases with age and burdens patients, the healthcare system, and society. We aimed to estimate the incidence, healthcare resource use (HCRU), and direct and indirect costs due to …

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The APOE ∗ 3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis

Marianne G. Pouwer, Suvi E. Heinonen, Margareta Behrendt, Anne‐Christine Andréasson et autres

Background. There is a lack of predictive preclinical animal models combining atherosclerosis and type 2 diabetes. APOE ∗ 3-Leiden (E3L) mice are a well-established model for diet-induced hyperlipidemia and atherosclerosis, and glucokinase+/− (GK+/−) mice are a translatable disease model for glucose control …

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Hyperglycemia does not affect tissue repair in mouse models of arterial lesions with different morphologies

Sabrina Hsiung, Anki Knutsson, Oscar van der Have, Johan Larsson et autres

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Hyperglycemia does not affect tissue repair responses in shear stress-induced atherosclerotic plaques in ApoE−/− mice

Sabrina Hsiung, Anki Knutsson, Jenifer Vallejo, Pontus Dunér et autres

The mechanisms responsible for macrovascular complications in diabetes remain to be fully understood. Recent studies have identified impaired vascular repair as a possible cause of plaque vulnerability in diabetes. This notion is supported by observations of a reduced content of fibrous proteins …

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A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes

Natalie R. van Zuydam, Emma Ahlqvist, Niina Sandholm, Harshal Deshmukh et autres

Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous …

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In vivo inhibition of nuclear factor of activated T-cells leads to atherosclerotic plaque regression in IGF-II/LDLR –/– ApoB 100/100 mice

Fabiana Blanco, Suvi E. Heinonen, Erika Gurzeler, Lisa M. Berglund et autres

Aims: Despite vast clinical experience linking diabetes and atherosclerosis, the molecular mechanisms leading to accelerated vascular damage are still unclear. Here, we investigated the effects of nuclear factor of activated T-cells inhibition on plaque burden in a novel mouse model of type …

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The APOE*3Leiden.GK+/- mouse as novel translational model for dyslipidemia, type 2 diabetes and macrovascular complications

Marianne G. Pouwer, Suvi E. Heinonen, Margareta Behrendt, Anne-Christine Andréasson et autres

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Hyperglycemia Induced by Glucokinase Deficiency Accelerates Atherosclerosis Development and Impairs Lesion Regression in Combined Heterozygous Glucokinase and the Apolipoprotein E-Knockout Mice

Damilola D. Adingupu, Suvi E. Heinonen, Anne‐Christine Andréasson, Mikael Brusberg et autres

Aim. Models combining diabetes and atherosclerosis are important in evaluating the cardiovascular (CV) effects and safety of antidiabetes drugs in the development of treatments targeting CV complications. Our aim was to evaluate if crossing the heterozygous glucokinase knockout mouse (GK+/−) and hyperlipidemic …

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Impaired Coronary and Renal Vascular Function in Spontaneously Type 2 Diabetic Leptin-Deficient Mice

Helena U. Westergren, Julia Grönros, Suvi E. Heinonen, Tasso Miliotis et autres

BACKGROUND: Type 2 diabetes is associated with macro- and microvascular complications in man. Microvascular dysfunction affects both cardiac and renal function and is now recognized as a main driver of cardiovascular mortality and morbidity. However, progression of microvascular dysfunction in experimental models …

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Animal Models of Diabetic Macrovascular Complications: Key Players in the Development of New Therapeutic Approaches

Suvi E. Heinonen, Guillem Genové, Eva Bengtsson, Thomas Hübschle et autres

Diabetes mellitus is a lifelong, incapacitating metabolic disease associated with chronic macrovascular complications (coronary heart disease, stroke, and peripheral vascular disease) and microvascular disorders leading to damage of the kidneys (nephropathy) and eyes (retinopathy). Based on the current trends, the rising prevalence …

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[18F]Fluorodeoxyglucose Uptake in Atherosclerotic Plaques Is Associated With Reduced Coronary Flow Reserve in Mice

Sauli Uotila, Johanna M. U. Silvola, Pekka J. Saukko, Pirjo Nuutila et autres

OBJECTIVES: Coronary microvascular dysfunction, observed as impaired coronary vasodilator capacity, is an early manifestation of coronary artery disease. Inflammation plays an important role in different stages of atherogenesis. To study the role of vessel wall inflammation in the development of coronary dysfunction, …

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Lymphatic Vessel Insufficiency in Hypercholesterolemic Mice Alters Lipoprotein Levels and Promotes Atherogenesis

Taina Vuorio, Harri J. Nurmi, Karen S. Moulton, Jere Kurkipuro et autres

OBJECTIVE: Lymphatic vessels collect extravasated fluid and proteins from tissues to blood circulation as well as play an essential role in lipid metabolism by taking up intestinal chylomicrons. Previous studies have shown that impairment of lymphatic vessel function causes lymphedema and fat …

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