Luc Defebvre

Motor complications and postural abnormalities interplay in Parkinson's disease

Margherita Fabbri, Aymeric Lanore, Nathalie Bertille, Jean-Christophe Corvol et autres

fr, us (code pays fourni par la source)

Disease Progression in Multiple System Atrophy: The ASPIRE Multi‐Modal Biomarker Study

Margherita Fabbri, Natalia del Campo, Wassilios G. Meissner, Vanessa Rousseau et autres

OBJECTIVE: The objective of this study was to characterize changes in candidate biomarkers in early multiple system atrophy (MSA) and identify baseline predictors of faster progression. METHODS: This 1-year, multicenter, prospective study assessed clinical, neuroimaging (3T-magnetic resonance imaging [MRI], dopamine transporter single-photon …

fr, gb (code pays fourni par la source)

Subcutaneous Apomorphine Infusion Initiation Is Associated with Impulse Control Disorder Attenuation in Advanced Parkinson's Disease Patients: Insights from the French NS ‐Park Cohort

Clément Desjardins, Paulo André Dias Bastos, Aymeric Lanore, Christine Brefel‐Courbon et autres

BACKGROUND: Impulse control disorders (ICD) are common non-motor complications in Parkinson's disease (PD), particularly in patients receiving oral dopamine agonists (DA). Continuous subcutaneous apomorphine infusion (CSAI) is a device-aided therapy for advanced PD, but its effects on ICD remain underexplored in real-world …

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Conservative iron chelation for VAC14: Two-year clinical-radiological follow-up

Thomas Ollivier, David Devos, Grégory Kuchcinski, Luc Defebvre et autres

There is a distinct lack of consensus on the most effective treatments for neurodegeneration with brain iron accumulation. This is due to the rarity of the disease, its phenotypic variability, and the multiplicity of pathophysiological mechanisms. Our team has already proposed the …

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Introduction

Luc Defebvre, Marc Vérin

Signes moteurs et critères diagnostiques

Guillaume Carey, Luc Defebvre

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Clinical prognostic factors in progressive supranuclear palsy: Implications for clinical trials

Felix Marchand, Anne-Sophie Blaise, Luc Defebvre, Émeline Cailliau et autres

BACKGROUND: Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease with diverse clinical phenotypes, prompting the development of new diagnostic criteria known as the MDS-PSP classification. However, little is known about the prognostic value of this classification in order to better stratify …

fr (code pays fourni par la source)

Pediatric-onset PRKN disease: New insights into an understudied population

Özge Gönül Öner, Valérie Fraix, Veronique Bourg, Luc Defebvre et autres

Background In pediatric age, the PRKN mutation is reported as one of the most common genetic causes of Parkinson's disease. However, detailed clinical data on PRKN patients with pediatric onset are scarce. Objective To describe clinical characteristics, disease progression, and management of …

fr (code pays fourni par la source)

Postural balance and visual dependence in patients with demyelinating neuropathies differ between acquired and hereditary etiologies

Ludovic Dupont, Luc Defebvre, Jean‐Baptiste Davion, Arnaud Delval et autres

BACKGROUND: Demyelinating polyneuropathies affect posture and can be either hereditary, as in Charcot-Marie-Tooth type 1A (CMT1A), or autoimmune, as in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Clinical differentiation between these two neuropathies can be challenging and biomarkers are lacking. No comparative analysis of …

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[Parkinson disease].

Guillaume Carey, Luc Defebvre

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The plurality of mechanisms of gait initiation disorders in Parkinson’s disease: Relationships with motor, cognitive and limbic functions

Morgane Gérard, Madli Bayot, Kathy Dujardin, Luc Defebvre et autres

fr (code pays fourni par la source)

Étude prospective des biomarqueurs de marche et d’IRM multimodale chez les patients de la cohorte GAIT’N’PARK présentant une atrophie multisystématisée

Felix Marchand, Romain Viard, Luc Defebvre, David Devos et autres

fr (code pays fourni par la source)