Emily Dong

In-process analytics for IVT mRNA manufacturing: from process understanding to advanced process control

Naryeong Kim, Emily Dong, Kate Tschudi, Julien Camperi

transcription (IVT) reaction, in-process measurements are increasingly applied across the product lifecycle, albeit with distinct objectives in process development versus current good manufacturing practice (cGMP) production. Within the U.S. Food and Drug Administration's Process Analytical Technology framework, we categorize in-process analytical methods …

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A homogeneous high-DAR antibody–drug conjugate platform combining THIOMAB antibodies and XTEN polypeptides

Neelie T. Zacharias, Vladimir N. Podust, Kimberly K. Kajihara, Douglas D. Leipold et autres

Efficiency of targeted cell delivery of small molecules was enhanced in cells and animals via a novel well-defined bioconjugation platform combining site-specific antibody conjugation and XTEN polypeptides to enable high payload loading.

us (code pays fourni par la source)

Nursing Care in the Critical Setting

Emily Dong, Tara Dade, Anitra Romfh

us (code pays fourni par la source)

Self-expanding intestinal expansion sleeves (IES) for short gut syndrome

Sean D. Clayton, J. Steven Alexander, Giovanni F. Solitro, Luke A. White et autres

us (code pays fourni par la source)

A homogeneous high-DAR antibody-drug conjugate platform combining THIOMABTM antibodies and XTEN polypeptides

Neelie T. Zacharias, Vladimir N. Podust, Kimberly K. Kajihara, Douglas D. Leipold et autres

Abstract Antibody-drug conjugates (ADCs) enable cell-specific delivery of small molecules and are validated anti-cancer therapeutics. One factor limiting ADC advancement and broader application is the drug-to-antibody ratio (DAR), which dictates the number of payloads that can be delivered per antibody. With few …

us, ch (code pays fourni par la source)

A 40-Year-Old Man With Tricuspid Atresia, Status Post-Fontan, With Severe COVID-19 Pneumonia and Pneumothorax

Sumeet S. Vaikunth, Michael Bykhovsky, Anitra Romfh, Christiane Haeffele et autres

We report a case of COVID-19 in an adult single-ventricle patient post-Fontan—to our knowledge, the first report in this population documenting the use of the latest management recommendations for this novel disease. Additionally, this patient had significant pre-existing ventricular dysfunction, valvular disease, …

us (code pays fourni par la source)

Vertebrate features revealed in the rudimentary eye of the Pacific hagfish ( Eptatretus stoutii )

Emily Dong, W. Ted Allison

Hagfish eyes are markedly basic compared to the eyes of other vertebrates, lacking a pigmented epithelium, a lens and a retinal architecture built of three cell layers: the photoreceptors, interneurons and ganglion cells. Concomitant with hagfish belonging to the earliest-branching vertebrate group …

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Eye, The

Emily Dong, W. Ted Allison

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Predicting 10-year mortality in adults with congenital heart disease

Susan M. Fernandes, George K. Lui, Amy E. Lin, Ian S. Rogers et autres

Advances in the management of patients with congenital heart disease (CHD) have made survival to adulthood an expectation. Although the literature is limited, existing evidence suggests that adult co-morbidities may be at least as prevalent in patients with CHD, if not more …

us (code pays fourni par la source)

Concurrent transfection of randomized transgene configurations into targeted integration CHO host is an advantageous and cost‐effective method for expression of complex molecules

Emily Dong, Cynthia Lam, Danming Tang, Salina Louie et autres

Complex recombinant proteins are increasingly desired as potential therapeutic options for many disease indications and are commonly expressed in the mammalian Chinese hamster ovary (CHO) cells. Generally, stoichiometric expression and proper folding of all subunits of a complex recombinant protein are required …

sg, us (code pays fourni par la source)

Nrl Is Dispensable for Specification of Rod Photoreceptors in Adult Zebrafish Despite Its Deeply Conserved Requirement Earlier in Ontogeny

A. Phillip Oel, Gavin J. Neil, Emily Dong, Spencer D. Balay et autres

The transcription factor NRL (neural retina leucine zipper) has been canonized as the master regulator of photoreceptor cell fate in the retina. NRL is necessary and sufficient to specify rod cell fate and to preclude cone cell fate in mice. By engineering …

ca (code pays fourni par la source)

Vertebrate features revealed in the rudimentary eye of the Pacific hagfish ( Eptatretus stoutii )

Emily Dong, W. Ted Allison

SUMMARY Hagfish eyes are markedly basic compared to the eyes of other vertebrates, lacking a pigmented epithelium, a lens, and a retinal architecture built of three cell layers – the photoreceptors, interneurons & ganglion cells. Concomitant with hagfish belonging to the earliest-branching …

ca (code pays fourni par la source)