Weilong Zhong

Regulatory role of POSTN in keloid pathogenesis

Bin Jiang, Fan Zhuo, Xiahong Li, Kaoyuan Zhang et autres

Keloids are an inflammatory cutaneous condition, which are characterized by fibroproliferative overgrowth of the skin. Although keloids are not life‑threatening, their incidence and recurrence are relatively high, thus decreasing the quality of life of patients due to pain, pruritus and cosmetic reasons. …

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Lactococcus formosensis and its metabolite 4-acetamidobutanoic acid induced caspase-11 dependent myenteric neuronal pyroptosis in intractable functional constipation

Xiaoqian Dong, Mengshi Chen, Haifeng Liu, Ming Sun et autres

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Serum SERPINB3/4 in Moderate‐to‐Severe Prurigo Nodularis: A Potential Biomarker for Disease Severity and Eosinophil‐Related Parameters

Kaoyuan Zhang, Yan Shin J. Liao, Chener Yang, Joy Yang Ge et autres

BACKGROUND: The available evidence increasingly indicates that SERPINB3/4 plays a pivotal role in the progression of inflammatory diseases and may serve as a valuable biomarker for atopic dermatitis and psoriasis. However, the expression of SERPINB3/4 in the serum of patients with moderate-to-severe …

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YAP1 facilitates the pathogenesis of psoriasis via modulating keratinocyte proliferation and inflammation

Cong Huang, Wenting Li, Changbing Shen, Bin Jiang et autres

Psoriasis is an autoinflammatory skin disease characterized by the abnormal activation of epidermal keratinocytes. The Hippo-YAP pathway is an evolutionarily conserved pathway that plays important roles in organ size control and tumorigenesis. Recently, accumulating evidence demonstrated that YAP1, the core downstream component …

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Machine learning-based characterization of PANoptosis-related biomarkers and immune infiltration in ulcerative colitis: A comprehensive bioinformatics analysis and experimental validation

Changshan Wan, Qiuyan Wu, Yali Wang, Yan Sun et autres

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Lysine 2-Hydroxyisobutyrylation of PFKP Facilitates Macrophage Metabolic Remodeling in High Fat Diet-Induced Colitis

Tianyu Liu, Qiao Chu, Chen Wang, Yu‐Cheng Gu et autres

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Pathogenesis and management of TRPV3-related Olmsted syndrome

Aobo Lu, Kezhen Li, Cong Huang, Bo Yu et autres

Olmsted syndrome is characterized by symmetrically distributed, destructive, inflammatory palmoplantar keratoderma with periorificial keratotic plaques, most commonly due to gain-of-function mutations in the transient receptor potential vanilloid 3 (TRPV3) gene, which involves multiple pathological functions of the skin, such as hyperkeratosis, dermatitis, …

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Exploring the molecular mechanisms and shared gene signatures between celiac disease and ulcerative colitis based on bulk RNA and single-cell sequencing: Experimental verification

Changshan Wan, Tao Ji, Liwei Wang, Qiuyan Wu et autres

Many immune-mediated diseases have the common genetic basis, as an autoimmune disorder, celiac disease (CeD) primarily affects the small intestine, and is caused by the ingestion of gluten in genetically susceptible individuals. As for ulcerative colitis (UC), which most likely involves a …

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Comorbidities of prurigo nodularis in Chinese patients: A multicenter retrospective study

Mengting Yin, Weilong Zhong, Keren Zhou, Xia Dou

Prurigo nodularis (PN), as a subtype of chronic prurigo (CPG), is characterized by nodular lesions and severe pruritus, which significantly affect patients’ quality of life.[1] It has been observed that patients with PN often have comorbidities, including physical and mental diseases.[2] However, …

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Discovery of microRNA-derived RNAs and proteins in human cells

Haidong Wu, Xiaoqiang Huang, Weilong Zhong, Wenbo Li et autres

This package includes the predicted midRs and midPs, together with the source data and scripts for the prediction.

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Comorbidities of Prurigo nodularis in Chinese patients: a multicentre retrospective study

Mengting Yin, Weilong Zhong, Keren Zhou, Xia Dou

Abstract Prurigo nodularis is a chronic pruritic dermatological disease that is known to be associated with various comorbidities. However, there has been a lack of comorbidity comdition studies specifically focusing on Chinese patients with prurigo nodularis, resulting in a dearth of representative …

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Retraction Note: Hsp90β promotes aggressive vasculogenic mimicry via epithelial–mesenchymal transition in hepatocellular carcinoma

Jing Meng, Shuang Chen, Yue-Yang Lei, Jingxia Han et autres

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