2026
article
OpenAlex
Roopambara Singh Rathore, Ramesh Chand Gupta, Alka Gupta, Lakhan Singh et autres
Abstract: PURPOSE: To study the clinical profile of secondary glaucoma and its management in a tertiary eye care center. METHODS: This hospital-based, prospective study was conducted for 1 year, including patients with high intraocular pressure (IOP) >21 mmHg, a history of ocular …
in, us
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Accès ouvert
2025
erratum
OpenAlex
Raghuram Kandimalla, Farrukh Aqil, Sara Samir Alhakeem, Jeyaprakash Jeyabalan et autres
In the original publication [...].
us
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Accès ouvert
2025
article
OpenAlex
Bharat Bhosale, Ramesh Chand Gupta, Vrushali Khobragade, M. Shinkre et autres
Background: Chromatin is a complex of DNA, RNA, and proteins with a 3D structure crucial for regulating gene expression.Studying chromatin interactions reveals how genes are controlled and misregulated in diseases like cancer.Hi-C captures genomewide interactions but is costly and complex.Existing models rely …
in
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Accès ouvert
2025
article
OpenAlex
Disha Nagesh Moholkar, Raghuram Kandimalla, Jeyaprakash Jeyabalan, Jun Yan et autres
Abstract Despite advances in the treatment of lung cancer, the survival rate remains low due to lack of specificity and selectivity. The use of appropriate nano‐drug delivery vehicle can overcome these issues. Cannabidiol (CBD) has the potential to be used as a …
us
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2025
conference-abstract
OpenAlex
Disha Nagesh Moholkar, Raghuram Kandimalla, Jeyaprakash Jeyabalan, Ramesh Chand Gupta et autres
Abstract Lung cancer remains a leading cause of cancer-related deaths, with treatment specificity posing a major challenge. Thus, we aim to repurpose cannabidiol (CBD) as an antitumor agent, delivered via tumor-targeted exosomes (Exo). We demonstrated that oral CBD administration inhibited orthotopic lung …
us
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2025
conference-abstract
OpenAlex
Raghuram Kandimalla, Omar Sadi Sarkar, Disha Nagesh Moholkar, Margaret Wallen et autres
Abstract Immunotherapy, a rapidly advancing cancer treatment, influences the patient’s immune system to combat tumors. However, cancer cells evade T-cell immunosurveillance by overexpressing PD-L1 on their surfaces. Additionally, tumor-associated macrophages (TAMs) further complicate the therapeutic efficacy of immune checkpoint inhibitors (ICIs) within …
us
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2025
conference-abstract
OpenAlex
Raghuram Kandimalla, Margaret Wallen, Disha Nagesh Moholkar, Jeyaprakash Jeyabalan et autres
Abstract Gene therapy is an emerging field in cancer therapeutics that targets specific proteins to control cancer cell proliferation. In recent years, several attempts to treat lung cancer using gene therapy have shown promise, but clinical translatability remains a significant challenge. Factors …
us
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Accès ouvert
2024
article
OpenAlex
Raghuram Kandimalla, Disha Nagesh Moholkar, Suman Kumar Samanta, Neha Tyagi et autres
Background/Objectives: Lung cancer is one of the deadliest cancers, and drug resistance complicates its treatment. Mahanine (MH), an alkaloid from Murraya koenigii has been known for its anti-cancer properties. However, its effectiveness and mechanisms in treating non-small cell lung cancer (NSCLC) remain …
us, in
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2024
conference-abstract
OpenAlex
Raghuram Kandimalla, Margaret Wallen, Jeyaprakash Jeyabalan, Disha Nagesh Moholkar et autres
Abstract Nuclear factor erythroid 2-related factor 2 (NRF2) activation is the third most common genetic event in lung adenocarcinomas (25%), primarily induced by loss of function mutations in its master regulator, KEAP1. NRF2 is a key modulator of tumor growth and metabolic …
us
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2024
conference-abstract
OpenAlex
Raghuram Kandimalla, Disha Nagesh Moholkar, Margaret Wallen, Chuanlin Ding et autres
Abstract Cancer immunosurveillance involves a dynamic interplay between the host’s innate and adaptive immunity. The regulation of programmed death ligand-1 (PD-L1) expression on cancer cells has emerged as an attractive approach for cancer treatment. However, challenges such as the immunosuppressive tumor microenvironment, …
us
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2024
conference-abstract
OpenAlex
Disha Nagesh Moholkar, Raghuram Kandimalla, Margaret Wallen, Jeyaprakash Jeyabalan et autres
Abstract Emerging advances in gene therapy over the past few decades have revolutionized biomedical research. Our lab has pioneered bovine milk and colostrum-derived exosomes (Exo) and devised a nanoplatform for nucleic acid delivery achieving targetability with folic acid (FA) functionalization. We showed …
us
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Accès ouvert
2024
article
OpenAlex
Viktoriya S. Sidorenko, Ira S. Cohen, Kunchok Dorjee, Conceição A.S.A. Minetti et autres
The emergence of highly infectious pathogens with their potential for triggering global pandemics necessitate the development of effective treatment strategies, including broad-spectrum antiviral therapies to safeguard human health. This study investigates the antiviral activity of emetine, dehydroemetine (DHE), and congeneric compounds against …
us
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