Paul Webb

The story of Party Politics (so far)

Émilie Van Haute, Paul Webb, David M Farrell

This symposium marks the 30th anniversary of Party Politics , a leading journal in the study of political parties and organizations. Over three decades, the field has evolved in response to profound political and societal changes, including the rise of new parties, …

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Our survey of Green party members suggests Zack Polanski has the mandate to take his party in a more radical direction

Tim Bale, Paul Webb, Stavroula Chrona

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What do Britons Want in a Political Leader?

Tim Bale, Paul Webb, Stavroula Chrona

Complete genome sequences of sucrose non-fermenting non-O1/non-O139 Vibrio cholerae isolated from human soft tissue infection

Haejin Hwang, Geraldine Salo, Melanie Orth, Nicole Podemski et autres

ABSTRACT This paper describes the hybrid genome assembly of sucrose non-fermenting non-O1/non-O139 Vibrio cholerae isolated from human soft tissue infection. The hybrid assembled genome comprises two circular chromosomes with lengths of 3,001,999 bp and 1,264,051 bp, respectively, with a G + C …

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Rhythmic high-amplitude delta with superimposed spikes (RHADS): a treatment dilemma

Vanita Shukla, Paul Webb, Bashayer Almohaimeed, James Lee et autres

Pathognomonic EEG patterns have been described in genetic conditions such as Angelman and Rett syndromes. EEG patterns along the ictal-interictal continuum have been increasingly recognized with the greater availability of continuous EEG monitoring; however, treatment decisions may be difficult with unpredictable clinical …

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UK election: Reform and Green members campaigned more online – but pounded the pavements less

Tim Bale, Paul Webb, Stavroula Chrona

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International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily—Update 2023

Thomas P. Burris, Ian Mitchelle S. de Vera, Isabelle Côté, Colin A. Flaveny et autres

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1A. Thyroid hormone receptors in GtoPdb v.2023.1

Douglas Forrest, Anthony N. Hollenberg, Paul Webb

Thyroid hormone receptors (TRs, nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [12, 2]) are nuclear hormone receptors of the NR1A family, with diverse roles regulating macronutrient metabolism, cognition and cardiovascular homeostasis. TRs are activated by thyroxine (T4) and …

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Data from NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis

Suzanne A. Eccles, Andy Massey, Florence I. Raynaud, Swee Y. Sharp et autres

Abstract We describe the biological properties of NVP-AUY922, a novel resorcinylic isoxazole amide heat shock protein 90 (HSP90) inhibitor. NVP-AUY922 potently inhibits HSP90 (Kd = 1.7 nmol/L) and proliferation of human tumor cells with GI50 values of approximately 2 to 40 nmol/L, …

Supplementary Figure 5A-B from NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis

Suzanne A. Eccles, Andy Massey, Florence I. Raynaud, Swee Y. Sharp et autres

Supplementary Figure 5A-B from NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis

Supplementary Figures 1A-B from NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis

Suzanne A. Eccles, Andy Massey, Florence I. Raynaud, Swee Y. Sharp et autres

Supplementary Figures 1A-B from NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis

Supplementary Materials, Figure Legends 1-6, Tables 1-5 from NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis

Suzanne A. Eccles, Andy Massey, Florence I. Raynaud, Swee Y. Sharp et autres

Supplementary Materials, Figure Legends 1-6, Tables 1-5 from NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis