Huanling Zhang

An mRNA Tumor Nanovaccine Expressing Tumor Antigen Fused With Angiotensin II Facilitates Type 1 Conventional Dendritic Cell‐Mediated Anti‐Tumor Immunity

C. Xie, Guo H, Chunlei Dai, L Wang et autres

ABSTRACT mRNA‐based tumor vaccines have shown great potential as a promising immunotherapeutic approach with encouraging preclinical and clinical results. However, how to enhance the antigen presentation efficiency of mRNA‐encoded tumor antigens and the intensity of vaccine‐induced CD8 + T cell response remains …

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Tryptophan Metabolite Indole‐3‐Aldehyde Induces AhR and c‐MYC Degradation to Promote Tumor Immunogenicity

Lei Cui, Zining Wang, Zixuan Guo, Hongxia Zhang et autres

The role of tryptophan (Trp) and its metabolites in immune regulation is well-established, however, whether and how they regulate immunogenicity of tumor cells is not completely understood. In this study, a range of Trp metabolites are evaluated for their potential to modulate …

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RAC2 inhibition enhances tumor sensitivity to NK cell-mediated cytotoxicity

Hui Guo, Jie Hu, Zining Wang, Feifei Xu et autres

Background Natural killer (NK) cells are recognized for their ability to kill tumor cells for tumor control, but tumor cells often develop resistance to evade NK cell-mediated cytotoxicity. Identification of molecular mechanisms by which tumor cells evade from NK cell-mediated killing may …

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Association of Genetic Variations in Energy Metabolism Genes with Noise-Induced Hearing Loss in a Chinese Population: A Case–Control Study

Bing Wang, Shanfa Yu, Jie Jiao, Guizhen Gu et autres

OBJECTIVE: This study explored the relationship between susceptibility to single-nucleotide polymorphisms (SNP) and noise-induced hearing loss (NIHL) in a population exposed to occupational noise. METHODS: Workers exposed to noise in a steel enterprise in Henan Province were included in the study. Workers …

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Endothelial STING-JAK1 interaction promotes tumor vasculature normalization and antitumor immunity

Huanling Zhang, Zining Wang, Jiaxin Wu, Yongqiang Zheng et autres

Stimulator of interferon genes (STING) agonists have been developed and tested in clinical trials for their antitumor activity. However, the specific cell population(s) responsible for such STING activation-induced antitumor immunity have not been completely understood. In this study, we demonstrated that endothelial …

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Cancer cell-intrinsic biosynthesis of itaconate promotes tumor immunogenicity

Zining Wang, Lei Cui, Bitao Huo, Hongxia Zhang et autres

The Krebs cycle byproduct itaconate has recently emerged as an important metabolite regulating macrophage immune functions, but its role in tumor cells remains unknown. Here, we show that increased tumor-intrinsic cis-aconitate decarboxylase (ACOD1 or CAD, encoded by immune-responsive gene 1, Irg1) expression …

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Variations in the Cadherin 23 Gene Associated With Noise-Induced Hearing Loss

Jie Jiao, Shanfa Yu, Guizhen Gu, Guoshun Chen et autres

Background: The relationship between CDH23 gene variants and NIHL is unclear. This study investigates the association between cadherin 23 ( CDH23 ) gene variants and noise-induced hearing loss (NIHL). Methods: This is a case-control study. Workers who were exposed to noise from …

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Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity

Yongxiang Liu, Zifeng Wang, Huan Jin, Lei Cui et autres

The importance of trained immunity in antitumor immunity has been increasingly recognized, but the underlying metabolic regulation mechanisms remain incompletely understood. In this study, we find that squalene epoxidase (SQLE), a key enzyme in cholesterol synthesis, is required for β-glucan-induced trained immunity …

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Targeting MEK/COX-2 axis improve immunotherapy efficacy in dMMR colorectal cancer with PIK3CA overexpression

Kunwei Peng, Yongxiang Liu, Shousheng Liu, Zining Wang et autres

PIK3CA mutation or overexpression is associated with immunotherapy resistance in multiple cancer types, but is also paradoxically associated with benefit of COX-2 inhibition on patient survival of colorectal cancer (CRC) with mismatch repair deficiency (dMMR). This study examined whether and how PIK3CA …

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Rocky Desertification Feature Extraction and Spatio-temporal Evolution Analysis based on Decision Tree

Xiaohai Lu, Zi-yang Guo, Hongbo Yan, Huanling Zhang

Karst rocky desertification is a kind of land degradation phenomenon which is harmful and difficult to control. Rocky desertification monitoring based on remote sensing technology is an effective method. In this paper, Chongzuo and Qianxinan Prefecture in Guangxi Province are used as …

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A Nanovaccine Based on Adjuvant Peptide FK‐13 and l ‐Phenylalanine Poly(ester amide) Enhances CD8+ T Cell‐Mediated Antitumor Immunity

C. Xie, Xinru You, Hongxia Zhang, Jiahui Li et autres

Abstract Cancer vaccines have shown promise as effective means of antitumor immunotherapy by inducing tumor antigen‐specific T cell immunity. In this study, a novel peptide‐based tumor nanovaccine that boosts antigen presentation and elicits effective antitumor immunity is developed. The adjuvant characteristics of …

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Predicting potential climate change impacts of bioenergy from perennial grasses in 2050

Weiguo Liu, Kui Wang, Hongke Hao, Yan Yan et autres

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