Tomohiko Yamane

Error analysis of cerebral blood flow and oxygen metabolism in three-dimensional 15O-gas positron emission tomography acquisition

Keiji Shimizu, Keīichi Matsumoto, Wataru Omasa, Go Akamatsu et autres

jp (code pays fourni par la source)

First-In-Human Evaluation of [18F]Fluproxadine for Norepinephrine Transporter PET

Tomohiko Yamane, Hitoshi Iimori, Go Akamatsu, Yasuhiko Ikari et autres

BACKGROUND: Current norepinephrine transporter (NET) tracers used for cardiac sympathetic imaging and oncology are limited by radiosynthesis complexity, suboptimal image quality, or operational constraints. [18F]fluproxadine (formerly [18F]AF78) was developed to address these limitations by providing high NET affinity, favorable biodistribution, and an …

jp, de (code pays fourni par la source)

18F-FAPI-74 PET/CT findings of an inflammatory branchial cleft cyst mimicking cervical metastasis from carcinoma of unknown primary: A case report

Seiji Oyagi, Tomohiko Yamane, Takuya Yamamoto, Norio Yamamoto et autres

Fibroblast-activation protein inhibitor (FAPI) positron-emission tomography (PET) is emerging as a promising alternative to 18 F-fluorodeoxyglucose (FDG) PET for head-and-neck cancer. Herein, we describe the case of a 51-year-old man with a cystic level-II neck mass that was intensely FDG-avid and even …

jp (code pays fourni par la source)

[PET in Neurology: Imaging Pathology, Metabolism, and Disease Progression].

Tomohiko Yamane

Anti-amyloid-β therapies for Alzheimer's disease-lecanemab (Leqembi approved in September 2023) and donanemab (Kisunla®; approved in September 2024)-have been authorized in Japan and are now in clinical use. In parallel, amyloid positron emission tomography (PET) is now reimbursed by the national health insurance …

jp (code pays fourni par la source)

Streamlined Radiosynthesis of [18F]Fluproxadine (AF78): An Unprotected Guanidine Precursor Enables Efficient One-Step, Automation-Ready Labeling for Clinical Use

Xinyu Chen, Kaito Ohta, Hiroyuki Kimura, Yusuke Yagi et autres

Background/Objectives: [18F]Fluproxadine (formerly [18F]AF78) is a PET radiotracer targeting the norepinephrine transporter (NET) with potential applications in cardiac, neurological, and oncological imaging. Its guanidine moiety, while essential for NET binding, presents major radiosynthetic challenges due to high basicity and the harsh deprotection …

de, jp, us (code pays fourni par la source)

Optimizing [18F]FAPI-74 PET/CT imaging: insights from Early-phase tumor uptake and tissue contrast

Yuki Hoda, Keiji Shimizu, Hiroyuki Nishida, Yasuhiko Ikari et autres

BACKGROUND: Fibroblast activation protein inhibitor (FAPI) is a novel PET tracer that targets various malignant tumors. Although some studies have demonstrated that 68Ga-labeled FAPI PET provides diagnostic images shortly after injection, reports on early-phase imaging using [18F]FAPI-74 are limited. This study evaluated …

jp (code pays fourni par la source)

Measurement accuracy and practicality of 15O-gas PET using a high-sensitivity whole-body PET/CT scanner

Wataru Omasa, Keīichi Matsumoto, Keiji Shimizu, Nobuyuki Ohara et autres

jp (code pays fourni par la source)

Improving the image quality of short-time bone SPECT using cadmium-zinc-telluride detectors with SwiftScan.

Kazuto Funakoshi, Tomohiko Yamane, Eito Kozawa, Ichiro Matsunari

Objectives: This study aimed to evaluate the quality and associated quantitative values of bone single-photon emission computed tomography (SPECT) with and without SwiftScan using a semiconductor camera equipped with a cadmium-zinc-telluride detector. Methods: Ten patients with bone metastases from prostate cancer who …

jp (code pays fourni par la source)

Complete and partial spontaneous regression of metastases of lung cancer in a patient: Serial CT and 18F-fluodeoxyglucose PET/CT findings

Shota Tatsumoto, Yuji Ito, Tomohiko Yamane, Hideyuki Nishiofuku et autres

F-fluodeoxyglucose positron emission tomography with computed tomography (FDG-PET/CT). We observed that the rib metastasis with high FDG uptake on initial PET/CT was composed of cancer cells as well as intratumoral immune cells, whereas recurrent mediastinal lymph node metastasis with high FDG uptake …

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Improved Correlation of18F-Flortaucipir PET SUVRs and Clinical Stages in the Alzheimer Disease Continuum with the MUBADA/PERSI-Based Analysis

Yasuhiko Ikari, Go Akamatsu, Keīichi Matsumoto, Tomohiko Yamane et autres

The Alzheimer disease (AD) continuum is a neurodegenerative disorder with cognitive decline and pathologic changes. Tau PET imaging can detect tau pathology, and 18F-flortaucipir PET imaging is expected to visualize progression through the stages of AD, for which quantitative assessment is essential. …

jp (code pays fourni par la source)

False-positive [18F]FAPI-74 uptake caused by blood retention due to external jugular vein thrombus: Pitfall in the early-phase scan

Akihito Ohnishi, Tomohiko Yamane, Keiji Shimizu, Masahiro Sasaki et autres

jp (code pays fourni par la source)

Cardiac Sympathetic Nerve Function in Patients with Severe Aortic Stenosis Prior and After Transcatheter Aortic Valve Implantation

Ryuta Egi, Kenji Fukushima, Yohji Matsusaka, Tomohiko Yamane et autres

Background: While the non-invasive assessment of cardiac sympathetic nerve dysfunction is readily accessible, its applicability in invasive intervention for structural heart disease has received limited investigation. Our study aimed to clarify the cardiac sympathetic nerve function in patients with severe Aortic stenosis …

jp (code pays fourni par la source)