Qiang Tao

pH-responsive R848-loaded Cu MOF NPs potentiate anti-tumor immunity via synergistic photothermal therapy and immunotherapy in hepatocellular carcinoma

Qiang Tao, Guangquan Zhang, Ruixi Li, Yufu Peng et autres

Hepatocellular carcinoma (HCC), the most common type of liver cancer, remains a major cause of cancer-related mortality worldwide, with limited treatment options and poor prognosis in advanced stages. Immunotherapy has shown promise in treating advanced HCC, with the TLR7/8 agonist resiquimod (R848) …

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Chronic Pain Synergizes With High‐Fat Diet to Promote Cardiac Injury via c‐Jun N‐Terminal Kinase 1/Silent Information Regulator 1 Signaling Axis in Apolipoprotein E‐Deficient Mice

Lan Wei, Qiang Tao, Shan You, Yi Zhang et autres

BACKGROUND: Both hyperlipidemia and chronic pain were recognized risk factors for cardiac injury, which could lead to cardiovascular diseases. METHODS: Thirty-two male APOE-/- (apolipoprotein E-deficient) mice (C57BL/6 background, 1 month old) were randomly allocated to 4 groups (n=8/group): Sham group: high-fat diet+sham …

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Efficacy of immune checkpoint inhibitors combined with different chemotherapy in recurrent pancreatic cancer: a retrospective study

Qiang Tao, Lingmin Jiang, Ruiqi Wang, Xin Huang et autres

Objective Recurrence affects 65%-75% of pancreatic cancer (PC) patient post-resection. Established salvage strategies for recurrent PC are lacking, and systemic chemotherapy offers limited survival benefits. This study aimed to evaluate the efficacy and safety of immune checkpoint inhibitors (ICIs) combined with different …

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Retraction notice to “Molecular and cellular mechanisms of PDAC progression based on RETN-CAP1-mediated macrophage-fibroblast crosstalk: Action of ITGB5 and ITGB1 recombinant proteins” [Int. J. Biol. Macromol. 290 (2025) 139078]

Guangquan Zhang, Xiaozhun Huang, Ruixi Li, Shengjie Hong et autres

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Effects of Red Blood Cells Stored for Different Periods on Lung Injury in Rabbits With Endotoxic Shock

Xiao-Fang Zhou, Na Yao, Qiang Tao, She-Jun Hu et autres

This study investigated the effects of red blood cell (RBC) storage time in a rabbit model of endotoxic shock by assessing lung injury, surfactant protein-A (SP-A) expression, oxidative stress markers, and cytokine levels. Male New Zealand rabbits were divided into eight groups …

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The prognostic significance of cholesterol, high-density lipoprotein and glucose (CHG) index in evaluating all-cause mortality risk in metabolic dysfunction-associated steatotic liver disease (MASLD) individuals: evidence from two cohort studies

Jicai Wang, Guangjie Tu, Qiang Tao, Ruixi Li et autres

BACKGROUND: The prognostic assessment of metabolic dysfunction-associated steatotic liver disease (MASLD) is of critical importance. Although previous international studies have suggested an association between the cholesterol, high-density lipoprotein, and glucose (CHG) index and mortality in MASLD patients, its generalizability in the Chinese …

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Alpha‐Fetoprotein Is a Potential Biomarker for Pancreatic Ductal Adenocarcinoma ( PDAC ): A Case Report

Kaiwen Zhong, Xiaoying Wu, Xiaowen Lin, Maoyun Xie et autres

INTRODUCTION: Pancreatic ductal adenocarcinoma (PDAC) is often diagnosed at an advanced stage, with high rates of mortality and drug resistance. Carbohydrate antigen 19-9 (CA19-9) is a tumor biomarker for diagnosis and prognosis in PDAC. However, elevated alpha-fetoprotein (AFP) is exceedingly rare in …

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Nicotinamide N-Methyltransferase Inhibition Mitigates Cerulein-Induced Pancreatic Fibrosis via Galectin-3-Mediated Regulation of Stellate Cell Activation and Macrophage M2 Polarization in Mice

Niansheng Ren, Ruixi Li, Qiang Tao, Shengjie Hong et autres

Chronic pancreatitis (CP) is a chronic disease characterized by pancreatic fibrosis driven by pancreatic stellate cell activation and M2 polarization of macrophages. Nicotinamide n-methyltransferase (NNMT) is a methylase critically involved in fibrosis. Galectin-3 (LGALS3), a member of the galectin family, drives M2 …

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NFYB–lncRNA axis resets the tumor microenvironment to promote HCC aggressive progression by a positive feedback loop

Boxuan Zhou, Qiang Tao, Wu Wen, Jianan Tan et autres

Metastases are a primary cause of cancer-associated mortality; however, the mechanisms underlying aggressive progression have not been clearly elucidated. Genome-wide features of chromatin accessibility through ATAC-seq from HCC primary and metastatic tumors revealed that many distal regulatory elements spreading the genome become …

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The EZH2-NEAT1 epigenetic axis promotes cuproptosis sensitivity and modulates cancer cell migration in colorectal cancer

Ruibing Li, Qiang Tao, Xijie Chen, Chuanyuan Liu et autres

Background: Cuproptosis represents a promising therapeutic strategy for colorectal cancer (CRC), yet the epigenetic mechanisms governing cuproptosis sensitivity remain largely unexplored. Enhancer of zeste homolog 2 (EZH2), a key epigenetic regulator frequently overexpressed in CRC, may play a critical role in modulating …

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Puerarin-loaded injectable hydrogel mitigates skeletal muscle wasting in colorectal cancer cachexia by targeting inflammatory signaling and improving protein homeostasis

Ruibin Li, Qiang Tao, Haonan Huang, Xinhui Zhu et autres

Cancer cachexia (CC) is a complex, tumor-induced metabolic syndrome characterized by progressive skeletal muscle atrophy, systemic inflammation, and refractoriness to nutritional intervention, contributing to functional decline and increased mortality. Effective targeting of CC-induced skeletal muscle atrophy are major challenges in clinical treatment. …

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Delayed death of a child from chlorfenapyr poisoning: A case report and literature review

Yishan Zhan, Jing‐Feng Li, Qiang Tao, Shouhua Zhang

This was the first article reported a fatal case of chlorfenapyr poisoning in a child, and the typical symptoms before death include high fever, severe sweating, coma, and limb stiffness, and elevation of myocardial enzymes and myoglobin; neurological symptoms tend to appear …

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