JiHoon Kang

Phase II study of bipolar androgen therapy combined with sipuleucel-T for patients with metastatic castration resistant prostate cancer (mCRPC).

Joseph W. Kim, Daniel P. Petrylak, Michael E. Hurwitz, William K. Oh et autres

e17081 Background: Bipolar androgen therapy (BAT) is an investigational therapy comprising monthly supraphysiologic testosterone injections and continuous androgen deprivation therapy (ADT). BAT demonstrated clinical activity in patients with metastatic castration resistant prostate cancer (mCPRC) progressing on abiraterone acetate (Denmeade S et al …

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Transcriptome-based Deep Learning Model for Predicting Gemcitabine and Cisplatin Chemotherapy Response in Urothelial Carcinoma: Development and External Validation

J Y Kang, Hyun Jung Lee, Sang-Bo Oh, Jong Kil Nam et autres

BACKGROUND/AIM: Chemotherapy with gemcitabine and cisplatin remains the cornerstone of treatment for advanced urothelial carcinoma (UC), yet response rates vary significantly among patients. Predicting treatment response is crucial to avoid unnecessary toxicity and optimize therapeutic strategies. This study aims to develop a …

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Non-canonical dihydrolipoyl transacetylase promotes chemotherapy resistance via mitochondrial tetrahydrofolate signaling

Jung Seok Hwang, JiHoon Kang, Jae Hyun Kim, Kiyoung Eun et autres

Chemotherapy is often a primary treatment for cancer. However, resistance leads to therapeutic failure. Acetylation dynamics play important regulatory roles in cancer cells, but the mechanisms by which acetylation mediates therapy resistance remain poorly understood. Here, using acetylome-focused RNA interference (RNAi) screening, …

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Lipid metabolism in cancer stem cells: reprogramming, mechanisms, crosstalk, and therapeutic approaches

Haksoo Lee, Sujin Park, Jong Won Lee, Chaeyoung Lee et autres

Cancer stem cells (CSCs) are a highly plastic subpopulation of tumor cells with capabilities for self-renewal, therapy resistance, and metastasis. Recent evidence highlights lipid metabolic reprogramming as a central mechanism supporting these malignant traits. This review synthesizes current findings on key lipid …

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A non-invasive metabolomic biomarker for detecting cervical intraepithelial neoplasia and cervical cancer.

JiHoon Kang, Dongyong Lee, Seob Jeon, Eun‐Jung Yang et autres

5532 Background: Cervical intraepithelial neoplasia (CIN) is a precancerous lesion that can progress to cervical cancer, a leading malignancy affecting women worldwide. Although current screening strategies and diligent follow-up are essential for identifying high-grade CIN, there remains a critical need for minimally …

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Abstract 3862: OC201 and OC202e, potential inhibitors of cancer metastasis, suppress EMT in pancreatic cancer

Youngjin Kim, Dong Sub Jung, Sewon Kim, Shian‐Ying Sung et autres

Abstract Objective: Pancreatic cancer is among the most aggressive malignancies, associated with a very poor prognosis due to its rapid progression and resistance to conventional therapies, underscoring the urgent need for novel treatment approaches. Epithelial-mesenchymal transition (EMT) is a key process that …

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Correction: Prognostic Impact of Inflammation-Based Factors in Patients with Esophageal Squamous Cell Carcinoma Achieving Pathological Complete Response After Neoadjuvant Chemoradiotherapy Followed by Surgery

Ji Yong Kim, Jae Kwang Yun, Yong‐Hee Kim, Seung-Il Park et autres

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TMET-08. RADIATION-INDUCED SLC25A22 CONTRIBUTES TO GLIOBLASTOMA RADIORESISTANCE ACQUISITION THROUGH REMODELING GLUTAMATE METABOLISM

Byeongsoo Kim, Haksoo Lee, Dahye Kim, Junhyeong Park et autres

Abstract Glioblastoma Multiforme (GBM), a malignant primary brain tumor, is treated by surgical resection followed by chemo- and radiotherapy. Nevertheless, most GBM patients show dismal prognosis due to the radioresistance acquisition of GBM cells via metabolic rewiring. Therefore, it is urgently required …

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Prognostic Impact of Inflammation-Based Factors in Patients with Esophageal Squamous Cell Carcinoma Achieving Pathological Complete Response After Neoadjuvant Chemoradiotherapy Followed by Surgery

Ji Yong Kim, Jae Kwang Yun, Yong‐Hee Kim, Seung-Il Park et autres

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Transcriptome-based deep learning analysis identifies drug candidates targeting protein synthesis and autophagy for the treatment of muscle wasting disorder

Min Hak Lee, Bada Lee, Se Eun Park, Ga Eul Yang et autres

Sarcopenia, the progressive decline in skeletal muscle mass and function, is observed in various conditions, including cancer and aging. The complex molecular biology of sarcopenia has posed challenges for the development of FDA-approved medications, which have mainly focused on dietary supplementation. Targeting …

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Abstract 1551: Succinyl-CoA synthetase Beta-A: A novel metastasis promoting factor in lung cancer

JiHoon Kang, Jung Seok Hwang, Austin C. Boese, Sydney Shuff et autres

Abstract Changes in metabolism occur when cancer cells disseminate from primary sites and metastasize. Mitochondrial metabolism plays an essential role in various biological processes of cancer cells, but the underlying mechanism through which mitochondrial factors contribute to cancer metastasis remains largely elusive. …

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Transient and Dynamic Simulation of the Fluid Flow through Five-Way Electric Coolant Control Valve of a 100 kW Fuel Cell Vehicle by CFD with Moving Grid Technique

Soo-Jin Jeong, JiHoon Kang, Seong-Joon Moon, Gum-su Lee

In order to maintain the performance of a fuel cell vehicle, it is essential to maintain a constant temperature of the stack. Therefore, it is very important to distribute the optimal coolant flow rate to each major component under very diverse and …

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