Sridhar Muthusami

Intranasal administration of Burkholderia cepacia promotes progressive acute inflammatory changes in experimental BALB/c mice

Selvaraj Roshan, Thippeswamy Aishwarya, Ramappa Chidananda, Inupanurthi Suma Madhuri et autres

Abstract Burkholderia cepacia ( B. cepacia ) is an opportunistic pathogen with versatile virulence mechanisms. The pathogenesis of B . cepacia in the immunocompetent host following intranasal exposure largely remains ambiguous. Male BALB/c mice were intranasally inoculated with B. cepacia strain 20209 …

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Discovery of Efficient EGFR Inhibitors with the Assistance of Cheminformatics Approaches: Structure based Drug Design, Computational docking and ADME Parameters Analysis and Molecular dynamics simulation

Mohan Anbuselvan, Sridhar Muthusami

Cervical Cancer (CC), the fourth deadliest gynecologic malignancy among women globally. CC has been found to be primarily driven by cellular growth factors, thus, making then highly potential targets for therapy. Although, targeting the dysregulated kinase activity of the epidermal growth factor …

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Genome Editing Technologies for Cancer Therapy

Gautham Chengizkhan, Arumugam Rajavelu, Sridhar Muthusami, Vengatesh Ganapathy et autres

Cancer remains one of the leading causes of death worldwide, and the limitations of conventional therapies such as surgery, chemotherapy, and radiotherapy underscore the urgent need for innovative therapeutic strategies. While advances in early detection and treatment have improved outcomes in some …

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Influence of pteridines and statins on cancer: A therapeutic strategy targeting nitric oxide synthase (NOS) pathway

J.J. Johnson, Monisha Krishnan, Sasireka Manikandan, Nivetha Shanmuganathan et autres

• Nitric Oxide (NO), a key signaling molecule which may exhibit a dual response, indicating the apoptotic/growth arrest or cell survival pathways gets triggered when NO levels surpass a threshold which would be a therapeutic strategy for Cancer. • Tetrahydrobiopterin (BH4) is …

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Emerging Clinical Applications of MicroRNAs in Cancer

Mohamed Adil Althaf, Agalya Murugan, Afshan Sathar, Gautham Chengizkhan et autres

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MicroRNAs Involved in the Regulation of Critical Genes and Their Relevance in the Theragnostics of HPV-Driven Cervical Cancer

Sneha Krishnamoorthy, Vidya Balasubramanian, Jayapradha Gnanagurusamy, Rajalakshmi Sabanayagam et autres

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List of contributors

Nagarajan Aruljothi, Rayvathy Balasubramanian, Vidya Balasubramanian, Antara Banerjee et autres

Subcellular transport of epidermal growth factor receptor: diverse approaches in targeting epidermal growth factor receptor-driven cervical carcinoma

Sneha Krishnamoorthy, Loganayaki Periyasamy, Sridhar Muthusami

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Advancements of cytology in cervical cancer

Jayapradha Gnanagurusamy, Rajalakshmi Sabanayagam, Giulia Guerriero, Sridhar Muthusami

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Role of Wnt/β-catenin signaling pathway in cervical cancer: Strategies to overcome therapeutic resistance

Gautham Chengizkhan, Akash Guruswamy, Balaji Sadhasivam, Rayvathy Balasubramanian et autres

Advances in nanotechnology-based drug development and delivery for cervical cancer therapeutic strategies

Thimma Mohan Viswanathan, Sridhar Muthusami, Anitha Devadoss, Sudhagar Pitchaimuthu

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The role of immune checkpoint proteins PD1 and PD-L1 during cancer resistance

Vidya Balasubramanian, Sivasankaran Munusamy Ponnan, Sridhar Muthusami, Vijayakumar Velu

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