Arvind Dasari

Changes in Outcomes of Hepatic Cytoreduction for Neuroendocrine Liver Metastases over Two Decades: From Major Hepatectomy to Parenchyma-Sparing Approaches

Kyoji Ito, Mikel Madi, Jonathan J. Hue, Elsa M. Arvide et autres

BACKGROUND: Surgical and systemic management of neuroendocrine liver metastases (NELM) has evolved over the past decades. This study aimed to evaluate temporal changes in prognosis and identify factors associated with improved survival after hepatic cytoreduction for NELM. PATIENTS AND METHODS: Patients who …

us (code pays fourni par la source)

ASO Visual Abstract: Hepatectomy Plus Chemotherapy or Chemotherapy Alone for Resectable Liver and Unresectable Lung Metastases from Colorectal Adenocarcinoma (LUNA): A Randomized Phase II Trial

Ian W. Folkert, Reza Mehran, Ryan Sun, Van K. Morris et autres

us (code pays fourni par la source)

Mo1303 OCCULT PERITONEAL METASTASIS IN SMALL-BOWEL NEUROENDOCRINE TUMORS: PREDICTORS AND THE ROLE OF SURGICAL EXPLORATION

Taylor Neilson, Galen Gist, Kever A. Lewis, Laura R. Prakash et autres

938 CONCORDANCE OF SURVEILLANCE CTDNA ANALYSES AND OVERALL AND SITE-SPECIFIC RECURRENCE AFTER HEPATECTOMY FOR COLORECTAL LIVER METASTASES

Galen Gist, Kever A. Lewis, Arvind Dasari, Van Karlyle Morris et autres

Mo1303 OCCULT PERITONEAL METASTASIS IN SMALL-BOWEL NEUROENDOCRINE TUMORS: PREDICTORS AND THE ROLE OF SURGICAL EXPLORATION

Taylor Neilson, Galen Gist, Kever A. Lewis, Laura R. Prakash et autres

938 CONCORDANCE OF SURVEILLANCE CTDNA ANALYSES AND OVERALL AND SITE-SPECIFIC RECURRENCE AFTER HEPATECTOMY FOR COLORECTAL LIVER METASTASES

Galen Gist, Kever A. Lewis, Arvind Dasari, Van Karlyle Morris et autres

Abstract CT155: Phase 1b trial of NG-350A, a CD40 agonist antibody expressing adenoviral vector, in combination with chemoradiotherapy (CRT), in patients with mismatch repair-proficient (pMMR) locally advanced rectal cancer (LARC): Initial results from the FORTRESS study

Eric D Miller, Pannaga G. Malalur, Sonal Suresh Noticewala, Arvind Dasari et autres

Abstract Background: The CEDAR study (NCT03916510) showed that combining our first-generation oncolytic immunotherapy with CRT in LARC significantly improved the response rate (RR) by magnetic resonance imaging (MRI) compared to standard CRT alone, warranting further study. The ongoing FORTRESS study (NCT06459869) aims …

us, gb (code pays fourni par la source)

Hepatectomy Plus Chemotherapy or Chemotherapy Alone for Resectable Liver and Unresectable Lung Metastases from Colorectal Adenocarcinoma (LUNA): A Randomized Phase II Trial

Ian Wesley Folkert, Reza John Mehran, Ryan Sun, Van Karlyle Morris et autres

us (code pays fourni par la source)

Abstract A027: Mode of presentation and symptoms at diagnosis of early- and late-onset colorectal cancer: a large retrospective AI-powered analysis

Emerik Österlund, Berta Martín-Cullell, Sebastian Correa Cautino, Mahmoud Yousef et autres

Abstract Introduction Early-onset colorectal cancer (EOCRC) is a distinct clinical entity and a rising global challenge. As presentation and symptom patterns at diagnosis have implications for early detection and prognosis, we aimed to characterize differences between EOCRC and late-onset colorectal cancer (LOCRC) …

us (code pays fourni par la source)

Performance Comparison of RaDaR 1.0 and RaDaR ST Assays for Circulating Tumor DNA Detection Across Solid Tumor Types

Christopher G. Smith, Clodagh Murray, Kathryn E. Aziz, Tim Forshew et autres

Introduction: Circulating tumor DNA (ctDNA) represents a promising tool for detection of minimal residual disease (MRD) and treatment monitoring in patients with cancer. Assays designed to detect ctDNA must demonstrate reproducibility across technical updates. This study evaluated concordance between two versions of …

us (code pays fourni par la source)

Trials in progress: Alliance A022104/NRG-GI010—A randomized phase II/III trial testing the efficacy of triplet versus doublet chemotherapy regarding clinical complete response and disease-free survival in patients with locally advanced rectal cancer (LARC; the Janus Rectal Cancer trial).

Qian Shi, Arvind Dasari, Julio García‐Aguilar, Hanna Kelly Sanoff et autres

TPS3650 Background: A total neoadjuvant therapy (TNT) approach improves compliance with chemotherapy and increases rates of tumor response compared to neoadjuvant chemoradiation (CRT) alone in those with locally advanced rectal cancer. Recent data indicate that optimal sequencing of TNT involves consolidation (rather …

us (code pays fourni par la source)

Brain metastasis in patients with primary gastrointestinal malignancy on anti-HER2 therapy.

Anjali Vinocha, Arvind Dasari, Jing Li, Jane Varkey Thomas et autres

e16067 Background: The incidence of brain metastasis in gastrointestinal (GI) malignancies is rare, estimated at less than 1%. However, its occurrence is associated with devastating outcomes. With the advent and prolonged use of Anti-HER2 therapy in patients expressing HER2 in their primary …

us (code pays fourni par la source)