Junsha An

Inhibitory effect of blestriarene C on triple-negative breast cancer: Inducing ferroptosis and mitophagy via SESN2/AKT/FOXO4 axis

Junsha An, Pingting Chen, Mingyu Han, Heng Zhang et autres

BACKGROUND: Triple-negative breast cancer (TNBC) is a highly aggressive and treatment-resistant subtype of breast cancer, characterized by high rates of metastasis and mortality. This study aimed to identify and evaluate the therapeutic potential of blestriarene C (BC), a novel diphenanthrene compound, in …

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Targeting Anoikis Resistance in Lung Adenocarcinoma: Bletilla Striata Phenanthrene A Acts Through the circCNTLN/miR-877-3p/SESN2 Axis

Mingyu Han, Yuhan Wang, Pingting Chen, Xue Li et autres

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Gymconopin C exhibits anti-non-small cell lung cancer effect by regulating miR-6777-5p/ADRB2 pathway to promote mitophagy

Xue Li, Mingyu Han, Limei Zhang, Xiaofang Xie et autres

• Firstly identifies Gymconopin C-a compound isolated from Bletilla striata-as a potent anti-NSCLC agent suppressing cancer development. • First evidence that miR-6777-5p/ADRB2 axis regulates PINK/Parkin-mediated mitophagy in NSCLC pathogenesis. • Elucidates the mechnistic cascade: Gymconopin C → miR-6777-5p ↓ →ADRB2 ↑ →PINK/Parkin …

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Pharmacological effects and application prospects of mussel adhesive proteins

Junsha An, Zengmiao Hou, Jiaqi Li, Qing-Fang Bi et autres

, renowned for their exceptional adhesive properties. These proteins, rich in 3,4-dihydroxyphenylalanine (DOPA) residues, enable mussels to adhere firmly to surfaces in challenging environments. Due to these unique biochemical and mechanical characteristics, MAPs have attracted significant attention in the biomedical field, offering …

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Sodium's role and therapeutic targeting in cancer

Junsha An, Fu Peng

Cancer cells exhibit unique metabolic reprogramming characterized by a significant increase in intracellular sodium ion levels. Sodium influences cancer cell metabolism, immune function, and drug resistance, and can trigger a unique cell death pathway when overloaded. Sodium-related transporters regulate cellular sodium ion …

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Hydroxysafflor yellow A: a natural pigment with potential anticancer therapeutic effect

Yuhan Wang, Junsha An, Jianbo Zhou, Limin Chang et autres

(Safflower), has been widely proven to have good efficacy on cardiovascular diseases, atherosclerosis, cancer, and diabetes. However, no study has reported on the anticancer mechanisms of Hydroxysafflor yellow A (HSYA), a principal bioactive compound in safflower. This review discusses recent developments in …

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Identification of potential hub genes and biological mechanism in rheumatoid arthritis and non-small cell lung cancer via integrated bioinformatics analysis

Junsha An, Pingting Chen, Xin Li, Xiuchuan Li et autres

BACKGROUND: Although there is evidence of the association between RA and NSCLC, little is known about their interaction mechanisms. The aim of this study is to identify potential hub genes and biological mechanism in RA and NSCLC via integrated bioinformatics analysis. METHODS: …

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Regulated cell death in glioma: promising targets for natural small-molecule compounds

Mingyu Han, Sui Li, Huali Fan, Junsha An et autres

Gliomas are prevalent malignant tumors in adults, which can be categorized as either localized or diffuse gliomas. Glioblastoma is the most aggressive and deadliest form of glioma. Currently, there is no complete cure, and the median survival time is less than one …

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Identification of Potential Hub Genes and Biological Mechanism in Rheumatoid Arthritis and Non-Small Cell Lung Cancer Via Integrated Bioinformatics Analysis

Junsha An, Pingting Chen, Xin Li, Xiuchuan Li et autres

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