Rachel Thomas

Farnesoid x Receptor Deficiency Promotes Hepatocytic Injury in Cyp2c70 ‐Deficient Mice With a Human‐Like Bile Acid Composition

Hilde Dieke de Vries, Jinxiao Li, Kirill Ustyantsev, Milaine V. Hovingh et autres

BACKGROUND AND AIMS: Loss-of-function mutations in bile acid (BA)-activated farnesoid x receptor (FXR/NR1H4) cause severe neonatal liver pathology in humans, earlier referred to as progressive familial intrahepatic cholestasis type 5 (PFIC5). However, Fxr-deficient mice do not develop early-onset liver disease, possibly due …

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Loss of Early Growth Response Protein 1 in the Liver Leads to Hepatic Lipid Accumulation Driven by an Imbalance Between Fatty Acid β-Oxidation and Oxidative Phosphorylation

Cristy R.C. Verzijl, Dicky Struik, Albert Gerding, Roos E. Eilers et autres

Background and Aims: knockout studies suggest a role for EGR1 in metabolism, affecting insulin sensitivity, energy homeostasis, cholesterol biosynthesis, and circadian rhythm. However, its direct role in hepatic lipid metabolism remains unclear. This study aimed to investigate the function of EGR1 in …

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Lymphotoxin beta receptor -/- mice display altered B- and T-cell subpopulations in the bone marrow and peritoneal cavity after Toxoplasma gondii infection.

Marcel Helle, Ursula R. Sorg, Johannes Ptok, Rachel Thomas et autres

Lymphotoxin β receptor (LTβR/TNFRSF3) signaling plays a crucial role in immune defense. Notably, LTβR-deficient (LTβR -/-) mice exhibit severe defects in innate and adaptive immunity against various pathogens and succumb to Toxoplasma gondii infection. Here, we investigated the bone marrow (BM) and …

Lymphotoxin beta receptor -/- mice display altered B- and T-cell subpopulations in the bone marrow and peritoneal cavity after Toxoplasma gondii infection

Marcel Helle, Ursula R. Sorg, Johannes Ptok, Rachel Thomas et autres

ABSTRACT Lymphotoxin β receptor (LTβR/TNFRSF3) signaling plays a crucial role in immune defense. Notably, LTβR-deficient (LTβR -/- ) mice exhibit severe defects in innate and adaptive immunity against various pathogens and succumb to Toxoplasma gondii infection. Here, we investigated the bone marrow …

de, nl (code pays fourni par la source)

Double Right Coronary Artery Originating From Separate Ostia in an Older Female Cadaver With Cerebrovascular Disease: A Case Report

Rachel Thomas, Tierra Kindred, Selena Anand, Paul Foretich et autres

This case report presents an extraordinary finding: a double right coronary artery with each artery originating from separate ostia off the aorta. This case was discovered in the cadaver of a 76-year-old woman whose cause of death was cerebrovascular disease. We discuss …

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Return of intracranial beta oscillations and traveling waves with recovery from traumatic brain injury

Alex Vaz, Connor Wathen, Stephen P. Miranda, Rachel Thomas et autres

Traumatic brain injury (TBI) remains a pervasive clinical problem associated with significant morbidity and mortality. However, TBI remains clinically and biophysically ill-defined, and prognosis remains difficult even with the standardization of clinical guidelines and advent of multimodality monitoring. Here we leverage a …

us, fr (code pays fourni par la source)

Pulmonary Thromboembolism and Myocarditis Resulting from a Large Pacing-Lead-Associated Right Ventricular Thrombus in a Dog with Chronic Cough as Presenting Sign

Viktor Szatmári, Rachel Thomas

In the present case report, we describe the clinical course and postmortem findings of a 12-year-old Labrador retriever dog with a third-degree atrio-ventricular block that developed a chronic cough, and later dyspnea and weakness as a result of massive pulmonary thromboembolism 3 …

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Treatment of intestinal and liver features in cystic fibrosis mice by the osmotic laxative polyethylene glycol

Anna Bertolini, Vincent W. Bloks, Marijn Wilmink, Eline Bos et autres

BACKGROUND: Cystic Fibrosis (CF) is a genetic disease affecting multiple organs, primarily the lungs and digestive system. Improved pulmonary management significantly improved life expectancy of CF patients. As a result, extrapulmonary manifestations, including gastrointestinal and liver-related symptoms, have become more relevant. We …

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Study protocol for Running for Health (Run4Health): a randomized controlled trial investigating the effect of Frame Running (RaceRunning) training on cardiovascular health in children and youth with cerebral palsy

Sarah Reedman, Ellen Armstrong, Leanne Sakzewski, Stina Oftedal et autres

ABSTRACT Introduction It is well established that young people with moderate-severe (Gross Motor Function Classification System [GMFCS] levels II-V) cerebral palsy (CP) participate in less physical activity compared to typically developed peers, and children with CP who can walk without limitations (GMFCS …

au, us (code pays fourni par la source)

The Histopathological Characteristic of Gastric Carcinoma in the Belgian Tervueren and Groenendael Dog: A Comparison of Two Classification Methods

Christina Kijan, Sanne Hugen, Rachel Thomas, Anita M. Oberbauer et autres

Gastric carcinoma is generally considered to be a rare disease in dogs, carrying a grave prognosis. However, in the Tervueren and Groenendael varieties of the Belgian Shepherd dog breed, the disease is highly prevalent. While histopathology is the gold standard for diagnosing …

nl, us, gb (code pays fourni par la source)

Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for Glycogen Storage Disease type Ia

Martijn G. S. Rutten, Lei Yu, Joanne H. Hoogerland, Vincent W. Bloks et autres

BACKGROUND: Glycogen storage disease type 1a (GSD Ia) is an inborn error of metabolism caused by a defect in glucose-6-phosphatase (G6PC1) activity, which induces severe hepatomegaly and increases the risk for liver cancer. Hepatic GSD Ia is characterized by constitutive activation of …

nl, se, fr, Tunisie (code pays fourni par la source)

Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for Glycogen Storage Disease type Ia

Martijn G. S. Rutten, Lei Yu, Joanne H. Hoogerland, Vincent W. Bloks et autres

Abstract Background Glycogen storage disease type 1a (GSD Ia) is an inborn error of metabolism caused by a defect in glucose-6-phosphatase (G6PC1) activity, which induces severe hepatomegaly and increases the risk for liver cancer. Hepatic GSD Ia is characterized by constitutive activation …

nl, se, Mali (code pays fourni par la source)