David M. Swoboda

U2AF regulates the translation and localization of nuclear-encoded mitochondrial mRNAs

Gloria R. Garcia, Murali Palangat, Josquin Moraly, Benjamin Donovan et autres

The mechanisms underlying molecular targeting to mitochondria remain enigmatic, yet this process is crucial for normal cellular function. The RNA-binding proteins U2AF1 and U2AF2 form a heterodimer (U2AF) that shuttles between the nucleus and cytoplasm, regulating splicing in the nucleus and translation …

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Artificial intelligence-driven virtual tumor board enhances precision care in myelodysplastic syndromes

David M. Swoboda, Amy E DeZern, James T. England, Sangeetha Venugopal et autres

Abstract Background Large language models (LLMs) perform well on standardized medical exam questions, but their reliability for complex hematology decision making is uncertain. We compared four general-purpose LLMs (GPT-4o, GPT-o3, Claude Sonnet 4, and DeepSeek-V3) with a Virtual MDS Panel (VMP), a …

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Oral azacitidine maintenance improved survival for t-AML or AML-MR patients in first remission after CPX-351 and not eligible to HSCT

Caroline Fileni, David M. Swoboda, Alexander Coltoff, Najla Al Ali et autres

Abstract Background Oral AZA (Onureg, CC-486) is a maintenance therapy administered at the dose of 300 mg daily, 14 days of a 28-day cycle [1] and approved by the FDA on September 1, 2020 [2]. Based on the results of the QUAZAR …

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Acute Myeloid Leukemia

David M. Swoboda, Kendra Sweet

U2AF regulates the translation and localization of nuclear-encoded mitochondrial mRNAs

Gloria R. Garcia, Murali Palangat, Josquin Moraly, Benjamin Donovan et autres

The mechanisms underlying molecular targeting to mitochondria remain enigmatic, yet this process is crucial for normal cellular function. The RNA-binding proteins U2AF1 and U2AF2 form a heterodimer (U2AF) that shuttles between the nucleus and cytoplasm, regulating splicing in the nucleus and translation …

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U2AF Regulates the Translation and Localization of Nuclear-Encoded Mitochondrial mRNAs

Gloria R. Garcia, Murali Palangat, Josquin Moraly, Bixuan Wang et autres

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Data from Clonal Hematopoiesis Is Associated with Increased Risk of Severe Neurotoxicity in Axicabtagene Ciloleucel Therapy of Large B-Cell Lymphoma

Neeraj Saini, David M. Swoboda, Uri Greenbaum, Junsheng Ma et autres

Abstract To explore the role of clonal hematopoiesis (CH) in chimeric antigen receptor (CAR) T-cell therapy outcomes, we performed targeted deep sequencing on buffy coats collected during the 21 days before lymphodepleting chemotherapy from 114 large B-cell lymphoma patients treated with anti-CD19 …

Data from Clonal Hematopoiesis Is Associated with Increased Risk of Severe Neurotoxicity in Axicabtagene Ciloleucel Therapy of Large B-Cell Lymphoma

Neeraj Saini, David M. Swoboda, Uri Greenbaum, Junsheng Ma et autres

Abstract To explore the role of clonal hematopoiesis (CH) in chimeric antigen receptor (CAR) T-cell therapy outcomes, we performed targeted deep sequencing on buffy coats collected during the 21 days before lymphodepleting chemotherapy from 114 large B-cell lymphoma patients treated with anti-CD19 …

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Clonal Hematopoiesis Is Associated with Increased Risk of Severe Neurotoxicity in Axicabtagene Ciloleucel Therapy of Large B-Cell Lymphoma

Neeraj Saini, David M. Swoboda, Uri Greenbaum, Junsheng Ma et autres

To explore the role of clonal hematopoiesis (CH) in chimeric antigen receptor (CAR) T-cell therapy outcomes, we performed targeted deep sequencing on buffy coats collected during the 21 days before lymphodepleting chemotherapy from 114 large B-cell lymphoma patients treated with anti-CD19 CAR …

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PET/CT scan and biopsy-driven approach for safe anti-PD-1 therapy discontinuation in patients with advanced melanoma

Geoffrey T. Gibney, Jacob P. Zaemes, Shelly Shand, Neil J. Shah et autres

Background Limited data exist on safe discontinuation of antiprogrammed cell death protein 1 (PD-1) therapy in responding patients with advanced melanoma. The use of 18fluorodeoxyglucose ( 18 FDG)-PET/CT scan and tumor biopsy for assessment of active disease may be an effective predictive …

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Clonal hematopoiesis is associated with increased toxicity in large B-cell lymphoma patients treated with chimeric antigen receptor T cell therapy

Neeraj Saini, David M. Swoboda, Uri Greenbaum, Jungsheng Ma et autres

Abstract To explore the role of clonal hematopoiesis (CH) on chimeric antigen receptor (CAR) T-cell therapy outcomes, we performed targeted deep-sequencing on 114 large B-cell lymphoma patients treated with anti-CD19 CAR T-cells. We detected CH in 42 (36.8%) pre-treatment patient samples, most …

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Evaluating Predictors of Immune-Related Adverse Events and Response to Checkpoint Inhibitors in Myeloid Malignancies

Quinto Gesiotto, David M. Swoboda, Rory M. Shallis, Najla Al Ali et autres

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