Andrei Leonov

Anle138b ameliorates pathological phenotypes in mouse and cellular models of Huntington’s disease

Miguel da Silva Padilha, Seda Koyuncu, Evangeline Chabanis, Sergey Ryazanov et autres

Huntington's disease (HD) is a hereditary movement disorder caused by a CAG repeat expansion in the huntingtin gene. HD is characterized by deposition of mutant huntingtin (mHTT) aggregates, and by severe neurodegeneration of the basal ganglia and neocortex. No cure is currently …

de (code pays fourni par la source)

Structural insight into binding of novel PET tracer MODAG-005 to lipidic 𝛼-Synuclein fibrils

Christian Griesinger, Myeongkyu Kim, Dirk Matthes, Benedikt Frieg et autres

nl, il, de (code pays fourni par la source)

Characteristic Features of Laser-Induced Fluorescence Parameters in Alexandrium catenella and Their Dependence on Temperature

Aleksandr Popik, Sergei Voznesenskii, Andrei Leonov, Anton Zinov et autres

Harmful algal blooms (HABs) pose a serious threat to public health, aquaculture, and coastal ecosystems, making the development of tools for their rapid and specific detection a high priority. Laser-induced fluorescence (LIF) spectroscopy enables the assessment of characteristic photosynthetic pigments, offering a …

ru (code pays fourni par la source)

A Navigation-Oriented Conformal Atlas of the Observable Universe (ΛCDM-Compatible)

Andrei Leonov

We present a navigation-oriented conformal atlas of the observable universe, fully compatible with standard ΛCDM cosmology. The construction compactifies the infinite comoving domain into a finite hyperbolic disk without introducing a physical boundary. The cosmological horizon is interpreted as a geometric limit …

A Navigation-Oriented Conformal Atlas of the Observable Universe (ΛCDM-Compatible)

Andrei Leonov

We present a navigation-oriented conformal atlas of the observable universe, fully compatible with standard ΛCDM cosmology. The construction compactifies the infinite comoving domain into a finite hyperbolic disk without introducing a physical boundary. The cosmological horizon is interpreted as a geometric limit …

[11C]MODAG 005 – a PET tracer targeting alpha-synuclein aggregates in the brain

Ran Sing Saw, Sabrina Buss, Felix Schmidt, Sergey Ryazanov et autres

de, il, us (code pays fourni par la source)

Anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation

Mookyoung Han, Benedikt Frieg, Dirk Matthes, Andrei Leonov et autres

Alzheimer's disease is a specific neurodegenerative disorder, distinct from normal aging, with a growing unmet medical need. It is characterized by the accumulation of amyloid plaques in the brain, primarily consisting of amyloid beta (Aβ) fibrils. Therapeutic antibodies can slow down the …

de (code pays fourni par la source)

The clinical drug candidate anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation.

Christian Griesinger, Mookyoung Han, Benedikt Frieg, Dirk Matthes et autres

de, il (code pays fourni par la source)

The clinical drug candidate anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation

Mookyoung Han, Benedikt Frieg, Dirk Matthes, Andrei Leonov et autres

Abstract Alzheimer’s disease is a specific neurodegenerative disorder, distinct from normal aging, with a growing unmet medical need. It is characterized by the accumulation of amyloid plaques in the brain, primarily consisting of amyloid beta (Aβ) fibrils. Therapeutic antibodies can slow down …

de, il (code pays fourni par la source)

The oligomer modulator molecule anle138b ameliorates Huntington’s disease phenotypes in vivo

Seda Koyuncu, Sergey Ryazanov, Andrei Leonov, Evangeline Chabanis et autres

de (code pays fourni par la source)

Structural insight into binding of novel PET tracer MODAG-005 to lipidic α -Synuclein fibrils

Myeongkyu Kim, Dirk Matthes, Benedikt Frieg, Andrei Leonov et autres

Abstract Accumulation of α-synuclein (αSyn) aggregates in the human brain is the major hallmark of synucleinopathies such as Parkinson’s Disease, Multiple System Atrophy, and Dementia with Lewy bodies. Positron Emission Tomography (PET) plays a vital role in diagnosing these diseases and monitoring …

de, il (code pays fourni par la source)

Seeing Double: The Persistent Dimer‐of‐Dimers Structure of Drug Resistant Influenza A M2

Μarianna Stampolaki, Abel Cherian Varkey, Evgeny Nimerovsky, Andrei Leonov et autres

The currently circulating S31N variant of the M2 proton channel of influenza A is resistant to antiviral drugs. Recently, there has been a growing concern regarding the impact of the lipid environment on the structural features of the S31N variant. The native …

de (code pays fourni par la source)