Amanda Reyes

Clinicogenomic Characteristics and Treatment Outcomes of Patients With Advanced ALK -Rearranged Squamous and Adenosquamous Non–Small Cell Lung Cancers

Emily A. Miao, Beow Yong Yeap, Sameh Daher, Meghanne Lomibao et autres

PURPOSE Anaplastic lymphoma kinase (ALK) is an established therapeutic target in non–small cell lung cancer (NSCLC), predominantly identified in adenocarcinomas. However, ALK rearrangements also occur in de novo squamous and adenosquamous NSCLCs and their clinicogenomic features remain poorly defined. METHODS This multi-institutional …

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Evaluating Clinical Factors Including HPV Clearance on Survival Outcomes in HPV+ Oropharyngeal Carcinoma

Amanda Reyes, Sean Maroongroge, Michelle Afkhami, Victoria Meucci Villaflor et autres

Background: The relationship between detectable circulating tumor DNA levels and clinical outcome following definitive therapy in patients with human papillomavirus (HPV)-mediated oropharyngeal squamous cell carcinoma has not been well established. Methods: In this retrospective analysis of patients with HPV-positive oropharyngeal squamous cell …

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Current paradigm of EGFR in non-small cell lung cancer: A long way forward

Beatriz Viesser Miyamura, Isa Mambetsariev, Jeremy Fricke, Javier Arias-Romero et autres

EGFR ins20 alterations are detected in 5% to 12% of the EGFR mutated subgroup in advanced non-small cell lung cancer. Historically, these alterations have been correlated with worse prognosis among the common EGFR mutation subtypes, which largely respond only to chemotherapy. The …

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Neoadjuvant tepotinib in stage IIB N0 non-small cell lung carcinoma with MET exon 14 skipping mutation: a case report and review of the literature

Amanda Reyes, Rebecca R. Pharaon, Atish Ranjan Mohanty, Jae Hyeong Kim et autres

Background: -targeted peri-operative treatment in lung cancer and highlight the relevant trials. Case Description: Ex14 mutation in surgically resectable stage IIB N0 NSCLC, who was not an optimal candidate for traditional chemotherapy for several reasons. Conclusions: -targeted tyrosine kinase inhibitors in the …

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Novel Immune Modulatory Agents in the Treatment of Non-small Cell Lung Cancer

Amanda Reyes, Matthew Lee

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Sequence-Driven Classification of DNA Aptamer by Target Type Using TF-IDF based Ensemble Models

Amanda Reyes, Sahith Goli, Andres Medina, Andrew Takayama et autres

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Different effects of fatty acid oxidation on hematopoietic stem cells based on age and diet

Salma Merchant, Animesh Paul, Amanda Reyes, Daniel Cassidy et autres

C-palmitate tracing and metabolomic analysis that hematopoietic stem/progenitor cells (HSPCs) engage in long-chain fatty acid oxidation that depends upon carnitine palmitoyltransferase 1a (CPT1a) and hydroxyacyl-CoA dehydrogenase (HADHA) enzymes. CPT1a or HADHA deficiency had little or no effect on HSPCs or hematopoiesis in …

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Clinical Utility of a Circulating Tumor Cell–Based Cerebrospinal Fluid Assay in the Diagnosis and Molecular Analysis of Leptomeningeal Disease in Patients With Advanced Non–Small Cell Lung Cancer

Jyoti Dhar Malhotra, Ramya Muddasani, Jeremy Fricke, Isa Mambetsariev et autres

PURPOSE: Leptomeningeal disease (LMD) is associated with significant morbidity and mortality for metastatic non-small cell lung cancer (NSCLC). We describe our clinical experience in evaluating the use of cerebrospinal fluid (CSF)-derived circulating tumor cells (CTCs) for the diagnosis of LMD and the …

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Leptin Receptor+ Stromal Cells Create a Perisinusoidal Niche for Thrombopoiesis in the Bone Marrow By Synthesizing Cxcl14

Yuanyuan Xue, Salma Merchant, Amanda Reyes, Maowu Luo et autres

Leptin Receptor expressing (LepR+) mesenchymal stromal cells are a critical source of multiple growth factors in the bone marrow that promote the maintenance of hematopoietic stem cells and early hematopoietic progenitors as well as the regeneration of hematopoietic and vascular cells. Here, …

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852 Potential of immunotherapy for BRAF-Mutated papillary thyroid cancer: insights from immune profiling and BRAF inhibition correlations

Atish Ranjan Mohanty, Michelle Afkhami, Amanda Reyes, Rebecca R. Pharaon et autres

Background Immune checkpoint inhibitors (ICIs) have become an effective treatment for advanced cancers, but their role in treating papillary thyroid cancer (PTC) remains uncertain. Although CD274 is present in thyroid cancers, trials with CD274 inhibitors have shown limited success, with an overall …

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Overcoming Resistance to Checkpoint Inhibitors with Combination Strategies in the Treatment of Non-Small Cell Lung Cancer

Amanda Reyes, Ramya Muddasani, Erminia Massarelli

Lung cancer continues to contribute to the highest percentage of cancer-related deaths worldwide. Advancements in the treatment of non-small cell lung cancer like immune checkpoint inhibitors have dramatically improved survival and long-term disease response, even in curative and perioperative settings. Unfortunately, resistance …

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Targeting PERK and GRP78 in colorectal cancer: Genetic insights and novel therapeutic approaches

Sahar Mafi, Mehdi Dehghani, Bahman Khalvati, Hassan Abidi et autres

Colorectal cancer (CRC) ranks among the leading causes of cancer-related deaths worldwide. Enhancing CRC diagnosis and prognosis requires the development of improved biomarkers and therapeutic targets. Emerging evidence suggests that the unfolded protein response (UPR) plays a pivotal role in CRC progression, …

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