It only takes seconds for a human monoclonal autoantibody to inhibit N-methyl-D-aspartate receptors
Shang Fa Yang, Johanna Heckmann, Abdulla Taha, Shiqiang Gao et autres
Abstract Transfer of autoantibodies targeting ionotropic N-methyl-D-aspartate receptors in autoimmune encephalitis patients into mice leads to typical disease signs. Long-term effects of the pathogenic antibodies consist of immunoglobulin G-induced crosslinking and receptor internalization. We focused on the direct and immediate impact of …
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bioRxiv (Cold Spring Harbor Laboratory)