Zijiao Guo

Long-read RNA-seq resolves isoform-level and context-specific regulatory architecture of complex traits in cattle

Lingzhao Fang, Weijie Zheng, Qi Zhang, Jinfeng He et autres

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Genetic associations of INHBE gene variants with milk production traits in dairy cattle

Meng Wang, Yanan Liu, Zijiao Guo, Bo Han et autres

The inhibin subunit beta E ( INHBE ) gene encodes activin E, a hepatokine belonging to the TGF-β superfamily, and plays important roles in regulating lipid metabolism, energy homeostasis and immune responses. Our previous study identified INHBE as a potential candidate gene …

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Pan-tissue transcriptomic profiling of dairy cattle

Jinfeng He, Ruike Jia, Aixia Du, Weijie Zheng et autres

BACKGROUND: Milk production in dairy cattle is a paradigmatic complex trait emerging from coordinated regulatory programs across multiple tissues and molecular layers, while previous transcriptomic studies have largely focused on a limited number of key tissues, most notably the mammary gland and …

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Long-read RNA-seq resolves isoform-level and context-specific regulatory architecture of complex traits in cattle

Weijie Zheng, Q Zhang, Jinfeng He, Xiaoning Zhu et autres

Abstract Traditional short-read RNA-seq lacks the resolution to fully capture full-length isoforms and complex alternative splicing, leaving a "missing regulation" gap in existing molecular atlases. Here, we present a population-scale, multi-omics dissection of bovine complex traits using matched deep whole-genome sequencing (30×), …

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Genetic and Functional Dissection of the NFKB2 Gene: Implications for Milk Fatty Acid Biosynthesis in Dairy Cattle

Lijun Shi, Zijiao Guo, Nan Shen, Cong Li et autres

Milk fat, an essential component of bovine milk, significantly impacts human health and dairy industry profitability. Our previous research identified that the NFKB2 gene was a key candidate for milk fatty acids (FAs) in dairy cattle. This study aimed to investigate the …

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Identification of Genetic Markers of APOM and CYP7A1 Genes Affecting Milk Production Traits in Chinese Holstein

Yanan Liu, Zijiao Guo, Junqing Ni, Chendong Yang et autres

Our previous study identified the apolipoprotein M (APOM) and cytochrome P450 family 7 subfamily A polypeptide 1 (CYP7A1) genes as candidates for milk traits in dairy cattle, which were significantly up-regulated in liver tissue of Holstein cows between the dry and lactation …

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Core promoter identification and transcriptional regulation of porcine ACSL3 gene

Xiaomin Li, Zijiao Guo, Xueying Ma, Huixin Liu et autres

Intramuscular fat (IMF) content is an important factor that affects the edible and processing quality of pork. Studying the transcriptional regulation mechanisms of genes affecting intramuscular fat deposition can provide theoretical support for genetic improvement in pigs. Long-chain fatty acyl-CoA synthase 3 …

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Genetic Association of APOA5 and AKT3 Genes with Milk Production Traits in Chinese Holstein Cows

Zijiao Guo, Aixia Du, Bo Han, Hui Li et autres

Genome selection (GS) technology is an important means to improve the genetic improvement of dairy cows, and the mining and application of functional genes and loci for important traits is one of the important bases for accelerating genetic improvement. Our previous study …

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PC Gene Affects Milk Production Traits in Dairy Cattle

Aixia Du, Zijiao Guo, Ao Chen, Lingna Xu et autres

In previous work, we found that PC was differentially expressed in cows at different lactation stages. Thus, we deemed that PC may be a candidate gene affecting milk production traits in dairy cattle. In this study, we found the polymorphisms of PC …

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