Phagocytosis-driven neurodegeneration through opposing roles of an ABC transporter in neurons and phagocytes
Xinchen Chen, Bei Wang, Ankita Sarkar, Nicolas Vergara Ruiz et autres
Lipid homeostasis is critical to neuronal survival. ATP-binding cassette A (ABCA) proteins are lipid transporters associated with neurodegenerative diseases. How ABCA transporters regulate lipid homeostasis in neurodegeneration is an outstanding question. Here we report that the Drosophila ABCA protein engulfment ABC transporter …
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