Junguo Liang

KPNA2 promotes lung adenocarcinoma progression by inducing glycolysis-assisted MYC nuclear translocation

Batter Han, Zhiyuan Deng, Rong Yu, Junguo Liang

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Expert Consensus on Subxiphoid and Subcostal Arch Thoracoscopic Resection for the Treatment of Thymoma

Xunliang Yin, Hongtao Duan, Zhengwei Zhao, Xiuyi Zhi et autres

Surgery is the primary treatment for thymoma. Although subxiphoid and subcostal arch thoracoscopic thymoma surgery is widely used, there is currently a lack of consensus regarding its use, nor have standards been established. Based on the surgical experience of many domestic thoracic …

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KAT8 enhances the resistance of lung cancer cells to cisplatin by acetylation of PKM2

Zhenyu Li, Xiangji Lu, Jing Zhang, Tao Liu et autres

Cisplatin (CDDP)-based chemotherapy resistance is a major challenge for lung cancer treatment. PKM2 is the rate-limiting enzyme of glycolysis, which is associated with CDDP resistance. KAT8 is an acetyltransferase that regulates lung cancer progression. Thus, we aimed to explore whether KAT8 regulates …

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Single-cell and bulk RNA sequencing data jointly reveals VDAC2’s impacts on prognosis and immune landscape of NSCLC

Ying Ma, Bateer Han, Qin Yu, Nashunbayaer Zha et autres

Non-small cell lung cancer (NSCLC) is characterized by stronger metastatic ability and worse prognosis. In NSCLC, hypoxia is a major cause of invasion and metastasis through promoting angiogenesis. In present study, NSCLC cell clusters were extracted from single cell-sequencing dataset GSE131907, which …

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