Profil bibliographique

Yangqin Duan

Informations fournies par OpenAlex. Research Africa ne déduit ni nationalité, ni poste, ni coordonnées personnelles.

2Publications signalées
24Citations signalées
2Affiliations récentes

Les institutions déclarées

Sichuan UniversityState Key Laboratory of Biotherapy

Les domaines associés

Computational Drug Discovery MethodsChemical Synthesis and AnalysisInflammasome and immune disordersGout, Hyperuricemia, Uric AcidReceptor Mechanisms and Signaling

Les publications récentes

Accès ouvert 2024 article OpenAlex

Discovery of Potent, Specific, and Orally Available NLRP3 Inflammasome Inhibitors Based on Pyridazine Scaffolds for the Treatment of Septic Shock and Peritonitis

Zhiyuan Fu, Yangqin Duan, Heying Pei, Yurong Zou et autres

The NLRP3 inflammasome is a multiprotein complex that is a component of the innate immune system, involved in the production of pro-inflammatory cytokines. Its abnormal activation is associated with many inflammatory diseases. In this study, we designed and synthesized a series of …

cn (code pays fourni par la source)

18 citations Journal of Medicinal Chemistry
2024 article OpenAlex

Local Scaffold Diversity-Contributed Generator for Discovering Potential NLRP3 Inhibitors

Weichen Bo, Yangqin Duan, Ziyan Ma, Tao Yang et autres

Deep generative models have become crucial tools in de novo drug design. In current models for multiobjective optimization in molecular generation, the scaffold diversity is limited when multiple constraints are introduced. To enhance scaffold diversity, we herein propose a local scaffold diversity-contributed …

cn, kr (code pays fourni par la source)

6 citations Journal of Chemical Information and Modeling
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