Xiaoduo Zhao

Transthyretin Contributes to Hippocampal Blood-Brain Barrier Recovery Following Intestinal Inflammation, with Reduced Expression in Alzheimer’s Disease

Zhi Xu, Jun Chen, Jiayi Yu, Jing Duan et autres

Abstract Background The blood-brain barrier (BBB) is increasingly recognized as an active immunoregulatory interface that responds dynamically to systemic inflammation. As intestinal inflammation can influence brain homeostasis through the gut-brain axis, the endogenous mechanisms that preserve BBB integrity during gut-derived inflammatory stress …

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Injectable Hydrogel with Persistent Interfacial Lubrication and Anti-Inflammatory for Osteoarthritis Therapy

Lumin Yang, Jianfei Liu, Xiaoduo Zhao, Pengbin Yin et autres

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Advanced surface lubrication modifications for medical catheters: Materials, strategies, and evaluation

Yuntong Liu, Lu Xu, Cheng Huang, Xuetao Wu et autres

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Universal Manufacturing of Multifunctional Composite Coatings with Integrated Anticorrosion, Super-Lubrication, and Antibacterial Properties for Diverse Metallic Substrates

Luyao Gao, Jialin Zhang, Haozhe Xu, Yizhe Liu et autres

The manufacture of biocompatible multifunctional medical metal materials constitutes a frontier challenge. Meanwhile, surface modification offers substantial potential for enhancing their functionality and broadening their application scope. Nevertheless, it remains crucial to customize and modify the surface of medical metal materials to …

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Mechanically Robust Super‐Lubrication Polycarbonate‐Polyurethane (PCU) Enabled by Design of Dynamic Mechanics Network and Manufacture of Constrained Hydrogel Coating

Bingbing Liu, Weiyi Zhao, Hai‐Bing Xu, Jinshuai Zhang et autres

Abstract Natural meniscus exhibits synergistic functions of load‐bearing, stress dissipation, and lubrication. Although synthetic materials show great potential for meniscus replacement, simultaneously exhibiting superior mechanical properties and robust super‐lubrication characteristics remains a significant challenge. Herein, a novel PCU material is developed that …

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Ecofriendly solutions for marine fouling: Synthesis and performance evaluation of waterborne zinc acrylate self-polishing coatings

Ketian Gao, Xuemei Bai, Bo Yu, Xiaowei Pei et autres

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#1805 Mechanosensitive cation channel Piezo1 regulates AQP2 expression in collecting ducts of the kidney

Meng Li, Xiaoduo Zhao, Weidong Wang, Chunling Li

Abstract Background and Aims Water reabsorption in the renal collecting duct, mediated by aquaporin-2 (AQP2), is essential for body fluid balance. Piezo1, a mechanosensitive cation channel, is highly expressed in the collecting ducts to sense mechanical and osmotic stress. The signal recognition …

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#2303 PDE5 inhibitor LW1646 improves kidney fibrosis by alleviating ER stress and mitochondrial calcium overload

Minghui Wang, Long Xu, Xiaoduo Zhao, Deyan Wu et autres

Abstract Background and Aims Renal fibrosis is the terminal pathological manifestation of most chronic kidney diseases (CKDs). Inhibitors targeting phosphodiesterase 5 (PDE5) have been used to treat erectile dysfunction and pulmonary arterial hypertension by increasing cGMP levels and activating the cGMP/PKG signaling …

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Constructing lubricious and anti-corrosion orthodontic appliances via dopamine-mediated zwitterionic polyelectrolyte brush codepositon on DLC coating

Min Zhang, Tao Li, Lunlin Shang, Nanyi Lin et autres

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Liquid‐Triggered Self‐Gelling Powder as Gradient Anti‐Swelling Sealant for Achieving Simultaneous Hemostasis and Anti‐Postoperative Adhesion

Siyao Lv, Jinshuai Zhang, Xiaoduo Zhao, Ying Sun et autres

Hydrogel-based wet-adhesion sealants are critical for wound sealing and repair, yet traditional hydrogel patches struggle to conform to irregular wounds while in situ self-curing systems commonly cause unintended tissue adhesion. To address these challenges, a gradient hydration concept for preparing the novel …

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Gut‐derived bacterial vesicles carrying lipopolysaccharide promote microglia‐mediated synaptic pruning

Xiaoduo Zhao, Jiayi Yu, Bin Xu, Zhi Xu et autres

INTRODUCTION: Growing evidence links gut microbiota (GM) to Alzheimer's disease (AD). Elevated lipopolysaccharide (LPS) levels, a Gram-negative bacteria component, are found in AD brains, but how LPS breaches the blood-brain barrier (BBB) remains unclear. Hypotheses suggest that bacteria-derived extracellular vesicles (bEVs) may …

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Superior anti-swelling and durably lubricious bio-hydrogels via robust crystalline domain construction for diverse biodevice coating

Weiyi Zhao, Yunlei Zhang, Xiaoduo Zhao, Bo Yu et autres

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