Keisuke Baba

Comment on “Phase II Study of Short Hydration without Diuretics for Cisplatin-Based Chemotherapy”

Gota Fujisawa, Keisuke Baba, Narikazu Boku

A phase II study evaluating the preventive effect of topical hydrocortisone for capecitabine-induced hand-foot syndrome in patients with colorectal cancer receiving adjuvant chemotherapy with capecitabine plus oxaliplatin (T-CRACC study)

Yohei Iimura, Keisuke Baba, Naoki Furukawa, Masaaki Ishibashi et autres

BACKGROUND: Topical steroids may help prevent capecitabine-induced hand-foot syndrome in patients with colorectal cancer, as inflammation is involved in anti-tumor agent-induced hand-foot syndrome development. We assessed the preventive efficacy of medium-class topical corticosteroids for capecitabine-induced hand-foot syndrome in patients receiving adjuvant chemotherapy …

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A phase II study evaluating the preventive effect of topical hydrocortisone for capecitabine-induced hand-foot syndrome in patients with colorectal cancer receiving adjuvant chemotherapy with capecitabine plus oxaliplatin (T-CRACC study)

Yohei Iimura, Keisuke Baba, Naoki Furukawa, Masaaki Ishibashi et autres

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A phase I/II trial evaluating the safety of increased-dose S- 1 with oxaliplatin and nivolumab in HER2-negative advanced gastric cancer

Keisuke Baba, Nobumi Suzuki, Chiyo K. Imamura, Eisuke Booka et autres

BACKGROUND: We developed and refined an S-1 dosage formula based on renal function, sex, and body surface area (BSA) to achieve the target area under the concentration-time curve of 5-fluorouracil in two prospective pharmacokinetic studies. The clinical validity of the refined formula …

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Reinfusion of Malignant Ascites through an Extracorporeal Peritoneal Venous Shunt to Avoid Complications and Assess the Safety of a Denver Shunt: A Case Report

Keisuke Baba, Tomoki Tanie, Yasuo Matsubara, Yoshihiro Hirata et autres

Introduction: Malignant ascites due to peritoneal metastasis of gastric cancer is challenging to manage, especially in frail and elderly patients. Traditional treatments like diuretics and paracentesis offer limited relief and can lead to complications such as malnutrition and dehydration. The Denver shunt, …

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Concentrations of Irinotecan and SN-38 in the Ascites and the Fluid Product of Cell-Free and Concentrated Ascites Reinfusion Therapy 9 Days After Administration of Irinotecan in a Patient with Gastric Cancer: A Case Report

Keisuke Baba, Tomoki Tanie, Yasuo Matsubara, Yoshihiro Hirata et autres

Introduction: Cell-free and concentrated ascites reinfusion therapy (CART) is frequently used to relieve the symptoms caused by massive ascites due to peritoneal metastasis of gastric cancer, especially in the later stages of its clinical course. Irinotecan (CPT-11) is recommended for third- or …

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Prevalence of Drug Fever among Cases of Nosocomial Fever: A Systematic Review and Meta-analysis

Hidehiro Someko, Yuuji Okazaki, Yasutaka Kuniyoshi, Akira Yoshida et autres

Objective Drug fever is defined as a fever that temporally coincides with the start of a culprit drug and disappears after discontinuation of the drug. It is a common cause of nosocomial fever, which refers to a fever that develops beyond the …

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Study protocol for a prospective observational study to evaluate the efficacy of fosnetupitant for long-delayed chemotherapy-induced nausea and vomiting in patients receiving platinum- based chemotherapy (LODEC-N)

Yohei Iimura, Hirotoshi Iihara, Takeshi Aoyama, Masaaki Ishibashi et autres

Abstract Background The efficacy of fosnetupitant (FosNTP) in combination with palonosetron and dexamethasone for preventing highly emetogenic chemotherapy-induced nausea and vomiting (CINV) was demonstrated in a phase III study (CONSOLE study). Although the exploratory analysis of the CONSOLE study suggested the efficacy …

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[Therapeutic Strategies Targeting HER2 for Gastric Cancer].

Keisuke Baba, Narikazu Boku

HER2-positive gastric cancer accounts for 30-40% of gastric cancer patients. Since the ToGA trial, trastuzumab has become the mainstay of first-line therapy for HER2-positive gastric cancer over the past decade. Antibody-drug conjugate (ADC)has created a new treatment option recently. The combination and …

Evaluation of clinical effects of a multidisciplinary-collaborated cancer support team for gastrointestinal cancer chemotherapy: prospective observational study protocol of M-CAST study

Yohei Iimura, Mitsuko Nakazawa, Yukari Tsuru, Hitomi Togashi et autres

BACKGROUND: Although the multidisciplinary-collaborated team approach in cancer treatment has recently become popular, prospectively evaluated evidence is limited. We started a multidisciplinary-collaborated cancer support team (MCST) to facilitate cooperation across multidisciplinary medical staff in our hospital and established clinical evidence of supportive …

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Case report: Irinotecan-induced interstitial lung disease in an advanced colorectal cancer patient resurfacing decades after allogeneic bone marrow transplantation for aplastic anemia; a case report and narrative review of literature

Keisuke Baba, Yasuo Matsubara, Yoshihiro Hirata, Yasunori Ota et autres

Two mechanisms of drug-induced interstitial lung disease (DILD) have been reported: 1) direct injury of lung epithelial cells and/or endothelial cells in lung capillaries by the drug and/or its metabolites and 2) hypersensitivity reactions. In both mechanisms, immune reactions such as cytokine …

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Evaluation of clinical effects of a multidisciplinary-collaborated cancer support team for gastrointestinal cancer chemotherapy: prospective observational study protocol of M-CAST study

Yohei Iimura, Mitsuko Nakazawa, Yukari Tsuru, Hitomi Togashi et autres

Abstract Background: Although the multidisciplinary-collaborated team approach in cancer treatment has recently become popular, prospectively evaluated evidence is limited. We started a multidisciplinary-collaborated cancer support team (MCST) to facilitate cooperation across multidisciplinary medical staff in our hospital and established clinical evidence of …

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