Tina Tan

A Rationally Designed Transgene Drives CAR T Functional Persistence and Durable Regression of Solid Tumors

Rupesh H. Amin, Kevin G. Haworth, Howell F. Moffett, Jerry C. Chen et autres

The eradication of solid tumors by chimeric antigen receptor (CAR) T cells requires dynamic therapies capable of outlasting an immune suppressive tumor microenvironment (TME). However, biological barriers—including rapid exhaustion, poor expansion, and loss of stem-like memory—quickly neutralize these therapies. Because single-technology interventions …

us (code pays fourni par la source)

A Dynamically Regulated Designed IL-2 for Tumor- localized Signaling

Howell F. Moffett, Brian D. Weitzner, Michelle M. Lissner, Thaddeus M. Davenport et autres

Cytokines mediate cell-cell communication to coordinate immune responses and hold clinical promise as immunotherapies. While natural cytokines are exquisitely regulated by immune cells, engineered cytokines have not yet matched this sophisticated regulation, limiting clinical efficacy and safety. IL-2 is an important cytokine …

us (code pays fourni par la source)

Poincaré disk as a model of squeezed states of a harmonic oscillator

Ian Chi, Martin Fraas, Tina Tan

Single-mode squeezed states exhibit a direct correspondence with points on the Poincaré disk. In this study, we delve into this correspondence and describe the motions of the disk generated by a quadratic Hamiltonian. This provides a geometric representation of squeezed states and …

us (code pays fourni par la source)

1085 OPB-101: a mesothelin-specific CAR T cell therapy leveraging protein design to enhance T cell proliferation and persistence for the treatment of ovarian cancer

Rupesh H. Amin, Howell F. Moffett, Kevin G. Haworth, Jerry Chen et autres

Background T cell therapies have shown modest efficacy in solid tumors, including ovarian cancer, due to limited functional persistence. OPB-101 consists of an optimized mesothelin (MSLN) CAR, a CD8α-targeted IL-2 designed cytokine to promote T cell expansion, and an improved EGFR safety …

us (code pays fourni par la source)

Parent attitudes, comfort, and perceptions about dating violence: The moderating effect on son report of parent openness to communicate.

Anna Cecilia McWhirter, D. Franz, Jaclyn Bogner, Christopher D. Houck et autres

Poincaré disk as a model of squeezed states of a harmonic oscillator

Ian Chi, Martin Fraas, Tina Tan

Single-mode squeezed states exhibit a direct correspondence with points on the Poincaré disk. In this study, we delve into this correspondence and describe the motions of the disk generated by a quadratic Hamiltonian. This provides a geometric representation of squeezed states and …

Abstract LB070: In vitro modeling of antigen-driven exhaustion in human CAR T cells

Maria M. Steele, Tina Tan, Jason K. Yokoyama, Allan W. Wang et autres

Abstract A major hurdle for chimeric antigen receptor (CAR) T cells to function in solid tumors is chronic antigen exposure leading to terminal lymphocyte exhaustion and impaired anti-tumor activity. Therefore, it is necessary to establish improved in vitro models of antigen-driven CAR …

Abstract 51: OPB-101: An optimized mesothelin-specific CAR T cell product expressing CD8-targeted IL-2/15 and engineered to resist T cell exhaustion

Rupesh P. Amin, Howell F. Moffett, Kevin G. Haworth, Jerry Chen et autres

Abstract T cell therapies have had modest efficacy in solid tumors due to their failure to proliferate following infusion. We have designed a mesothelin (MSLN) CAR T product (OPB-101) which includes a novel promoter (OP1), an optimized CAR, a safety switch, and …

Development of a Regulated, Optimized Mesothelin Chimeric Antigen Receptor (CAR) for the Treatment of Mesothelin Positive Cancers

Jason K. Yokoyama, Allan W. Wang, Maria M. Steele, John T. Crowl et autres

Introduction: Mesothelin (MSLN) is an attractive target for chimeric antigen receptor T cell (CAR-T) immunotherapy as it is highly expressed on mesothelioma, ovarian, lung cancer, and some forms of leukemia, including approximately 30% of acute myeloid leukemia (AML); however, MSLN directed CAR-T …

us (code pays fourni par la source)

A case for improving parent–child communication among multilingual‐immigrant populations

Tina Tan, Bethany M. Gen, Christopher Epting, Elizabeth C. Tampke

Parent–child communication plays a key role in adolescents' and parents' mental and behavioral health. Parent–child communication is associated with child well‐being outcomes, including socioemotional development (e.g., Grotevant, 2001), interpersonal relationships (e.g., Carson et al., 1999), and academic success (e.g., Branje, 2008; Noller …

Respiratory care in familial dysautonomia: Systematic review and expert consensus recommendations

Mikhail Y. Kazachkov, Jose‐Alberto Palma, Lucy Norcliffe‐Kaufmann, Bat‐Ami Bar On et autres

us, il (code pays fourni par la source)

Internet and smartphone application usage in eating disorders: A descriptive study in Singapore

Tina Tan, Angeline Kuek, Shih Ee Goh, Ee Lian Lee et autres

sg (code pays fourni par la source)