Christopher Ahern

Neural Correlates of Palliative Care: A Feasibility Trial in Patients with Metastatic Gastrointestinal and Lung Cancer

Eleni Fanouraki, JD Knotts, Cheryl Page, Amanda Perry et autres

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Metabolic regulation of the cardiac sodium channel

Daniel S. Matasic, Barry London, Christopher J. Benson, Charles Brenner et autres

Sudden cardiac death, an unexpected death by the loss of heart function (cardiac arrest), is a major health problem in the United States and in the rest of the world, accounting for 50% of all heart disease-related deaths and 15%-20% of all …

CamDavidsonPilon/lifelines: v0.23.8

Cameron Davidson-Pilon, Jonas Kalderstam, Paul N. Zivich, Ben Kuhn et autres

Bug fixes fixed important error when a parametric regression model would not assign the correct labels to fitted parameters. See more here: https://github.com/CamDavidsonPilon/lifelines/issues/931. Users of GeneralizedGammaRegressionFitter and any custom regression models should update their code as soon as possible.

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CamDavidsonPilon/lifelines: v0.23.4

Cameron Davidson-Pilon, Jonas Kalderstam, Paul N. Zivich, Ben Kuhn et autres

Bugfix for PyPI

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CamDavidsonPilon/lifelines: v0.22.9

Cameron Davidson-Pilon, Jonas Kalderstam, Paul N. Zivich, Ben Kuhn et autres

0.22.9 - 2019-10-30 Bug fixes fixed predict_ methods in AFT models when timeline was not specified. fixed error in qq_plot fixed error when submitting a model in qth_survival_time CoxPHFitter now displays correct columns values when changing alpha param.

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CamDavidsonPilon/lifelines: v0.22.3 (late)

Cameron Davidson-Pilon, Jonas Kalderstam, Paul N. Zivich, Ben Kuhn et autres

0.22.3 API changes removed lifelines.utils.gamma - use autograd_gamma library instead. Bug fixes AFT log-likelihood ratio test was not using weights correctly. corrected (by bumping) scipy and autograd dependencies

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CamDavidsonPilon/lifelines: v0.22.0

Cameron Davidson-Pilon, Jonas Kalderstam, Paul N. Zivich, Ben Kuhn et autres

New features Ability to create custom parametric regression models by specifying the cumulative hazard. This enables new and extensions of AFT models. percentile(p) method added to univariate models that solves the equation p = S(t) for t for parametric univariate models, the …

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Characterization of the modulatory effects of alternative splicing on Cav1.4 Ca2+ channels

Brittany Williams, Amy Lee, Nobutoshi Harata, Christopher Ahern et autres

In synaptic terminals of retinal photoreceptors, Cav1.4 (L-type) Ca2+ channels mediate Ca2+ influx that promotes neurotransmitter release. Mutations in Cav1.4 are associated with multiple vision disorders including congenital stationary night blindness type 2(CSNB2). Cav1.4 undergoes weak Ca2+-dependent inactivation (CDI) – a negative …

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Discrete IP3 signaling requirements underlie acute and chronic forms of homeostatic synaptic plasticity

Thomas D. James, Christopher Ahern, Toshihiro Kitamoto, Nobutoshi Harata et autres

Synapses must continuously maintain stable function in order for neuronal circuits and higher-order systems to properly function. By necessity, tight regulation of molecules necessary for appropriate neurotransmission coupled with homeostatic forms of plasticity function to stabilize synaptic output. The Drosophila melanogaster larval …