Yuhong Shang

Milk EVs Promote Apical Periodontitis Bone Repair via Osteoblast Targeting

Saixuan Wu, Hua Bai, Yuhong Shang, Zhengru Yan et autres

Chronic apical periodontitis (CAP), an inflammatory disease of periapical tissues, leads to alveolar bone destruction. Current therapies lack osteoblast-targeting specificity and fail to effectively promote bone repair. Extracellular vesicles (EVs), particularly milk-derived EVs (MEVs), show potential for bone regeneration and have anti-inflammatory …

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Integrative RNA-seq and LASSO-COX analysis reveal Paeonol’s key target gene in proliferation suppression and apoptosis-induced in cervical cancer

Miao Li, Na Gao, Lei Xu, Peng Ge et autres

Background: The natural compound paeonol exhibits therapeutic promise against cervical carcinoma, though its precise molecular mechanisms remain undefined. Methods: First, we treated human cervical cancer (HeLa) cells with different concentrations of paeonol. Cellular proliferation and apoptotic responses were evaluated via cell-counting kit …

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Assessing colposcopy competencies in medically underserved communities: a multi-center study in China

Xiaoli Cui, Mingyang Chen, Samuel Seery, Peng Xue et autres

BACKGROUND: Colposcopy plays an essential role in diagnosing cervical lesions and directing biopsy; however, there are few studies of the capabilities of colposcopists in medically underserved communities in China. This study aims to fill this gap by assessing colposcopists' competencies in medically …

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Progesterone inhibits endometrial cancer growth by inhibiting glutamine metabolism through ASCT2

Jinqiu Guo, Jianhui Fan, Yaru Zhang, Mengyue Li et autres

Endometrial carcinoma (EC) is a common malignancy that originates from the endometrium and grows in the female reproductive system. Surgeries, as current treatments for cancer, however, cannot meet the fertility needs of young women patients. Thus, progesterone (P4) therapy is indispensable due …

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Melatonin suppresses tumor proliferation and metastasis by targeting GATA2 in endometrial cancer

Yangyou Liao, Ruiling Li, Jingyuan Pei, Juan Zhang et autres

Endometrial cancer (EC) is a reproductive system disease that occurs in perimenopausal and postmenopausal women. However, its etiology is unclear. Melatonin (MT) has been identified as a therapeutic agent for EC; however, its exact mechanism remains unclear. In the present study, we …

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Perspectives on the Economic Integration of the Western Balkans into the European Union

Juan Zhang, Yuhong Shang

In this paper, the authors analyze the perspectives of the economic integration of the Western Balkans into the European Union (EU).The work is dedicated to the study of the exchange of the Western Balkans with the EU in comparison with the exchange …

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O-GlcNAc modification mediates aquaporin 3 to coordinate endometrial cell glycolysis and affects embryo implantation

Hongshuo Zhang, Jia Qi, Jingyuan Pei, Man Zhang et autres

O-linked β-D-N-acetylglucosamine (O-GlcNAc) modification is a post-translational modification in which a single O-GlcNAc is added to serine or threonine residues in nuclear, cytoplasmic, and mitochondrial proteins, and is involved in a variety of physiological processes. In the present study, the role of …

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Chimeric Antigen receptor-T (CAR-T) cells targeting Epithelial cell adhesion molecule (EpCAM) can inhibit tumor growth in ovarian cancer mouse model

Juan Fu, Yuhong Shang, Qian Zhang, Guodi Liu et autres

Ovarian cancer (OC) is one of the most lethal solid tumors with poor prognosis. In 2017, two chimeric antigen receptor-T (CAR-T) cell drugs were approved by the U.S. Food and Drug Administration (FDA), and continuously optimized CAR-T cells therapy might be the …

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Progesterone Regulates Glucose Metabolism Through Glucose Transporter 1 to Promote Endometrial Receptivity

Hongshuo Zhang, Jia Qi, Yufei Wang, Jing Sun et autres

Successful embryo implantation requires receptive endometrium, which is conducive to the process of embryo recognition, adhesion and invasion within a certain period of time and is inseparable from the dynamic interaction between 17β-estradiol (E2) and progesterone (P4). Proper glucose metabolism is critical …

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MiR‐30a‐5p inhibits proliferation and metastasis of hydatidiform mole by regulating B3GNT5 through ERK/AKT pathways

Zhenzhen Guo, Qiannan Sun, Yangyou Liao, Chao Liu et autres

Hydatidiform moles are gestational trophoblastic disease. They are abnormal proliferations of trophoblast cells that have the potential to become cancerous. miR-miR30a-5p is a tumour suppressor that participates in the development of numerous diseases. However, the role of miR-30a in hydatidiform moles and …

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BRMS1L suppresses ovarian cancer metastasis via inhibition of the β-catenin-wnt pathway

Penglong Cao, Shuai Zhao, Zhigang Sun, Nan Jiang et autres

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Osteopontin Promotes Bone Destruction in Periapical Periodontitis by Activating the NF-κB Pathway

Ming Dong, Xinxin Yu, Wanfang Chen, Zhenzhen Guo et autres

BACKGROUND/AIMS: Periapical periodontitis is caused by bacterial infection and results in both one destruction and tooth loss. Osteopontin (OPN) is a secreted phosphorylated glycoprotein that participates in bone metabolism. METHODS: Thirty-three patients with chronic periapical periodontitis and 10 patients who had undergone …

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