Rosemary Wilson

The CML and the ALL inducing isoforms of BCR::ABL1 differ for the induction of genomic instablity

Rosemary Wilson, Kierney O’Dare, Claudia Chriches, Susanne Saußele et autres

Abstract There are two major isoforms of BCR::ABL1, the Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) specific p185BCR::ABL1, and the p210BCR::ABL1, which defines 95% of chronic myeloid leukemia (CML). These two isoforms differ in the presence of the oncogenic pleckstrin- and DBL-homology …

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Damaging Alleles Affecting Multiple CARD14 Domains Are Associated with Palmoplantar Pustulosis

Athanasios Niaouris, Ariana Hernández-Cordero, Salma Haddad, Karoliina Hassi et autres

Palmoplantar pustulosis (PPP) is a severe pustular eruption that affects the palms and/or soles, with detrimental effects on quality of life. The disease is notoriously difficult to treat because its immune and genetic determinants remain poorly defined (Twelves et al., 2019). Although …

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Treatment of pustular psoriasis with anakinra: a statistical analysis plan for stage 1 of an adaptive two-staged randomised placebo-controlled trial

Suzie Cro, Catherine Smith, Rosemary Wilson, Victoria Cornelius

BACKGROUND: Palmoplantar pustulosis (PPP) is a rare, chronic inflammatory skin disease. It is known to affect quality of life at a level comparable to that from major medical and psychiatric illness, yet current treatment options are remarkably limited. Recent evidence however suggests …

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A small population, randomised, placebo-controlled trial to determine the efficacy of anakinra in the treatment of pustular psoriasis: study protocol for the APRICOT trial

Victoria Cornelius, Rosemary Wilson, Suzie Cro, David Burden et autres

BACKGROUND: Palmoplantar pustulosis is a rare but painful and debilitating disease. It consistently ranks the highest of all psoriasis phenotypic variants in terms of symptoms and functional impairment. Management of plaque-type psoriasis has been revolutionised in the last 10 years with the …

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Supplementary material : Clinical and genetic differences between pustular psoriasis subtypes

Sophie Twelves, Alshimaa Mostafa, Nick Dand, Elias Burri et autres

Clinical and genetic differences between pustular psoriasis subtypes

Sophie Twelves, Alshimaa Mostafa, Nick Dand, Elias Burri et autres

Background The term pustular psoriasis indicates a group of severe skin disorders characterized by eruptions of neutrophil-filled pustules. The disease, which often manifests with concurrent psoriasis vulgaris, can have an acute systemic (generalized pustular psoriasis [GPP]) or chronic localized (palmoplantar pustulosis [PPP] …

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Book review

Rosemary Wilson