Larisa Vakhonina

CT-620: Comparative Analysis of T-Cell Depletion Strategies in Pediatric Hematopoietic Stem Cell Transplantation

Anna Vlasova, Larisa Vakhonina, D. E. Kostenko, D. E. Klevakin et autres

POSTER: CT-620 Comparative Analysis of T-Cell Depletion Strategies in Pediatric Hematopoietic Stem Cell Transplantation

Anna Vlasova, Larisa Vakhonina, D. E. Kostenko, D. E. Klevakin et autres

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Tandem autologous hematopoietic stem cell transplantation is safe and effective for treatment of pediatric solid tumors: results of multicentre retrospective study in Russia

K. I. Kirgizov, Yu. A. Smirnova, Ilya Viktorovich Kazantsev, Svetlana A. Kuleva et autres

Introduction: Tandem autologous hematopoietic stem cell transplantation (aHSCT) is an integral part of modern approach to the treatment of pediatric high risk solid tumors.This confirms the actuality of multicenter studies of tandem aHSCT safery profile and efficacy.Methodology: This is a retrospective multicenter …

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Second allogeneic hematopoietic stem cell transplantation as salvage therapy in a patient with sepsis and severe hypofunction of hematopoiesis after chemotherapy

D. E. Klevakin, Larisa Vakhonina, A. A. Vlasova, D. E. Kostenko et autres

When performed in patients with severe infection, allogeneic hematopoietic stem cell transplantation is associated with high mortality rates due to the progression of infection and graft failure. Here, we report a case of a successful allogeneic hematopoietic stem cell transplantation performed in …

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Application of cytogenetic risk factors and molecular markers, assessed by multiplex ligation-dependent probe amplification for prognosis of outcome in pediatric B-cell precursor acute lymphoblastic leukemia do not bring any advantage over detection of isolated IKZF1 deletion

Grigory A. Tsaur, Alexander E. Druy, A. G. Solodonikov, A. M. Popov et autres

The purpose of the current work was the estimation of prognostic significance of cytogenetic and molecular markers, assessed by multiplex ligation-dependent probe amplification (MLPA) in 142 cases of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) patients. Good-risk genetic (GEN-GR) group consisted of …

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SIGNIFICANCE OF ETV6-RUNX1 FUSION GENE TRANSCRIPT DETECTION IN PEDIATRIC B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA WITH TRANSLOCATION t(12;21)(p13;q22)

Grigory A. Tsaur, Т О Ригер, Alexander M. Popov, Tatiana Verzhbitskaya et autres

Introduction. Translocation t(12;21)(p13;q22) is one of the most common structural genetic abnormalities in childhood acute lymphoblastic leukemia (ALL). It cannot be detected by conventional G-banding, so a reverse-transcriptase polymerase chain reaction (RT-PCR) or fluorescent in situ hybridization are used for this purpose.The …

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Transplantation of hematopoietic stem cells in the Regional Children’s Clinical Hospital № 1 in Ekaterinburg. Results of work for the period from 2006 to 2016

Larisa Vakhonina, Igor Vyatkin, Natalya Maysheva, V. A. Pudovkin et autres

This article represents results of work of Center of pediatric oncology and hematology of Regional pediatric clinical hospital № 1 of Yekaterinburg on Hematopoietic stem cell transplantation (HSCT) during the period 2006–2016. One hundred seventeen HSCT performed during this time including 70 …

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Influence of mixed chimerism upon outcomes of allogeneic stem cell transplantation (allo-SCT) in patients with non-malignant diseases

Larisa Vakhonina, Igor Vyatkin, Natalya Maysheva, Grigory A. Tsaur et autres

Влияние смешанного химеризма на результаты аллогенной трансплантации гемопоэтических стволовых клеток (ТГСК) у пациентов с незлокачественными заболеваниямиInfluence of mixed chimerism upon outcomes of allogeneic stem cell transplantation (allo-SCT) in patients with non-malignant diseases

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Does ATRA Confirm to Play a Role in the Better Relapse Free Survival of Infants with Acute Lymphoblastic Leukemia?

Л. Г. Фечина, Egor Shorikov, Olga Streneva, Olga Khlebnikova et autres

Abstract Abstract 1515 Treatment achievements in infant's acute lymphoblastic leukemia (ALL) are still very modest. Despite of many attempts, the creation of novel, based on the molecular mechanisms, clinically approved and safe therapy strategies for this group of patients (pts) seems to …

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Опыт получения выс0к00чищенн0й фракции CD34 -клеток периферической крови и костного мозга и их аутотрансплантация детям с нейр0бласт0м0й

Ю. А. Яковлева, Grigory A. Tsaur, Egor Shorikov, А А Игуменыцев et autres