Yujun Xia

CDK3 induces neuronal death and brain atrophy in Alzheimer’s disease

Kai H. Zhuang, Zi Liu, Xiao Su, Hu Chen et autres

cn, us (code pays fourni par la source)

Menin Deficiency Induces Autism‐Like Behaviors by Regulating Foxg1 Transcription and Participates in Foxg1‐Related Encephalopathy

Kai Zhuang, Lige Leng, Xiao Su, Shuzhong Wang et autres

FOXG1 syndrome is a developmental encephalopathy caused by FOXG1 (Forkhead box G1) mutations, resulting in high phenotypic variability. However, the upstream transcriptional regulation of Foxg1 expression remains unclear. This report demonstrates that both deficiency and overexpression of Men1 (protein: menin, a pathogenic …

cn (code pays fourni par la source)

Autonomous Indoor Navigation for Visually Impaired: A ROS-Based Intelligent Guide Robot with Deep Learning and SLAM Integration

Lu Zhang, Yan Chen, Zhen Yang, Huaiyi Zhang et autres

This study presents the design and implementation of an indoor intelligent guide robot for visually impaired individuals, leveraging ROS and deep learning technologies to facilitate autonomous navigation. The robot's architecture is detailed, highlighting the use of Jetson Nano for system control, STM32Fl …

cn (code pays fourni par la source)

Mesenchymal Stem Cells Ameliorate DSS-Induced Experimental Colitis by Modulating the Gut Microbiota and MUC-1 Pathway

Han Wang, Yang Sun, Fengjun Xiao, Xia Zhao et autres

Purpose: Mesenchymal stem cells (MSCs) have become novel therapeutic agents for the treatment of inflammatory bowel diseases (IBDs). However, the precise cellular and molecular mechanisms by which MSCs restore intestinal tissue homeostasis and repair the epithelial barrier have not been well elucidated. …

cn (code pays fourni par la source)

Specific bFGF targeting of KIM-1 in ischemic kidneys protects against renal ischemia-reperfusion injury in rats

Siqi Song, Xianglin Hou, Weiwei Zhang, Xinyu Liu et autres

Abstract Renal ischemia-reperfusion (I/R) injury is one of the major causes of acute kidney injury. However, there is still no effective treatment for this disease. Basic fibroblast growth factor (bFGF) has been reported to be beneficial for recovery from ischemic diseases. It …

cn (code pays fourni par la source)

Uncoupled spatial biodynamic model for seated humans exposed to vibration-development and validation

Zhenzhong Yu, Qinghai Zhao, James Yang, Yujun Xia et autres

cn, us (code pays fourni par la source)

Hyperbaric oxygen therapy mobilized circulating stem cells and improved delayed encephalopathy after acute carbon monoxide poisoning with up-regulation of brain-derived neurotrophic factor

Lina Zhang, Qing Feng Sun, Qun Xin, Jiangnan Qin et autres

cn (code pays fourni par la source)

A Transcriptome Sequencing Study on Genome‐Wide Gene Expression Differences of 3D Cultured Chondrocytes in Hydrogel Scaffolds with Different Gel Density

Weiyuan Zhang, Yujun Xia, Ling Yang, Wei Yang et autres

Hydrogel is considered as a promising cell delivery vehicle in cartilage tissue engineering, whose tunable microenvironments may influence the function and fate of encapsulated chondrocytes. Here, the transcriptomes of chondrocytes that are encapsulated and cultured in hydrogel constructs respectively made of 0.8% …

cn, hk (code pays fourni par la source)

Research Progress and Principle of Diffusion Tensor Imaging in Brachial Plexus

You Liang, Xueli Ji, Shuting Huang, Gao Yue et autres

抵抗スポット溶接品質監視技術の研究進展と分析【JST・京大機械翻訳】

Yujun Xia, Yongbing Li, Lou Ming, Lei Haiyang

Progress in Articular Cartilage Tissue Engineering: A Review on Therapeutic Cells and Macromolecular Scaffolds

Zhongyi Zhao, Changjiang Fan, Feng Chen, Yutai Sun et autres

Repair and regeneration of articular cartilage lesions have always been a major challenge in the medical field due to its peculiar structure (e.g., sparsely distributed chondrocytes, no blood supply, no nerves). Articular cartilage tissue engineering is considered as one promising strategy to …

cn, hk (code pays fourni par la source)

EGF-CP-HA水凝胶对大鼠皮肤创面愈合的影响

程连强, Cheng Lianqiang, 施春英, Shi Chunying et autres

目的通过胶原蛋白肽-透明质酸负载表皮生长因子(EGF-CP-HA)水凝胶在大鼠全层皮肤缺损伤口的应用来探讨其对皮肤伤口愈合的影响。 方法90只SD大鼠，麻醉后制备伤口创面动物模型，随机分为生理盐水(NS)组、透明质酸(HA)水凝胶组、胶原蛋白肽-透明质酸(CP-HA)水凝胶组、透明质酸负载表皮生长因子(EGF-HA)水凝胶组和EGF-CP-HA水凝胶组，每组18只。后4组大鼠在其皮肤伤口处分别贴敷相应水凝胶治疗。观察并记录创面愈合情况。分别在相应时间点麻醉大鼠后取伤口及其周缘1 cm的组织，行苏木精-伊红、Masson、免疫组化染色来观察损伤区域不同时间的组织病理变化、胶原纤维分布、血管内皮生长因子-α(VEGF-α)和转化生长因子-β1(TGF-β1)的表达。 结果EGF-CP-HA水凝胶组大鼠皮肤伤口愈合时间最短(F=6.46，P＜0.01)。苏木精-伊红染色显示，EGF-CP-HA水凝胶组创面炎性反应较NS组轻，毛细血管及胶原纤维生成较其他组多；Masson染色显示，EGF-CP-HA水凝胶组胶原纤维较其他组多，排列规则、有序，更接近正常皮肤；免疫组化染色显示，EGF-CP-HA水凝胶组TGF-β1和VEGF-α的表达强度均显著高于NS组(F=12.51~18.64，P＜0.05)。 结论EGF-CP-HA水凝胶可减轻皮肤创面的炎症反应，提高VEGF-α和TGF-β1的表达水平，明显促进伤口愈合。