Huiyuan Gong

A novel morpholine-functionalized flavone-based NIR fluorescent probe for imaging of β-amyloid aggregates and lysosomal viscosity

Hongbo Sun, 薛景娇, Huiyuan Gong, Wen Luo et autres

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A flavonoid-based near-infrared fluorescent probe for monitoring H₂O₂ dynamics during ferroptosis and drug-induced liver injury in vitro and in vivo

Huiyuan Gong, 薛景娇, Zihua Wang, Jinghua Li et autres

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Lysosome-targeted near-infrared fluorescent probes for monitoring aβ plaques in vivo and aβ monomers dynamic degradation in vitro

Huiyuan Gong, Zhuangqing Li, Yongmei Zhao, Zihua Wang et autres

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Synthesis and evaluation of novel indolopyridine derivatives as multi-target directed ligands for Alzheimer’s disease

Yongmei Zhao, Song Luo, Huiyuan Gong, Wen Luo

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The transcription factor ZEB2 mediates the antitumor efficacy of tumor-infiltrating lymphocytes in non–small cell lung cancer

Jiajia Wang, Fei Liu, Yongyong Li, Jiaojiao Gao et autres

Abstract Immune checkpoint blockade (ICB) offers an in vivo approach to activate CD8 + tumor-infiltrating lymphocytes (CD8 + TILs) in cases of advanced non–small cell lung cancer (NSCLC). A large fraction of NSCLC patients is unresponsive to ICBs and relapse due to …

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Novel flavone-based near-infrared fluorescent probe for the detection of H2S in vitro and in vivo

Huiyuan Gong, Zhihan Du, Hong Chen, Wen Luo

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A dicyanomethylene-4H-benzopyran based fluorescent probe for monitoring cysteine fluctuation during liver injury

Peixuan Cheng, Huiyuan Gong, Hui Zhou, Wen Luo et autres

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N,N-Dimethylaminonaphthyl-modified dicyanoisophorone near-infrared probe for dual-functional imaging of β-amyloid aggregates and lipid droplets

Huiyuan Gong, Ru Fang, Song Luo, Wen Luo et autres

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Abstract CT126: Aumolertinib as adjuvant therapy in patients with stage II-IIIB EGFR-mutated NSCLC after complete tumor resection: A randomized, double-blind, placebo-controlled, phase 3 trial (ARTS)

Ying Cheng, Xiqin Zhang, Lin Wu, Wenxiang Wang et autres

Abstract Background: Lung cancer is the primary cause of cancer-related morbidity and mortality globally. Approximately 30% of patients with EGFR mutation (EGFRm) in NSCLC are diagnosed at an early stage and are candidates for curative-intent surgical resection; however, disease recurrence remains a …

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Novel pyrrolidine-alkylamino-substituted dicyanoisophorone derivatives as near-infrared fluorescence probe for imaging β-amyloid in vitro and in vivo

Hui Zhou, Jihang Zhai, Huiyuan Gong, Ru Fang et autres

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PCSK5 downregulation promotes the inhibitory effect of andrographolide on glioblastoma through regulating STAT3

Huiyuan Gong, Xiaomin Yang, Lijun An, Wangming Zhang et autres

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Downregulation of MAL2 inhibits breast cancer progression through regulating β-catenin/c-Myc axis

Lijun An, Huiyuan Gong, Xiaojing Yu, Wangming Zhang et autres

PURPOSE: Myelin and lymphocyte protein 2 (MAL2) is mainly involved in endocytosis under physiological conditions and mediates the transport of materials across the membranes of cell and organelle. It has been reported that MAL2 is significantly upregulated in diverse cancers. This study …

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