Yanhong Shang

An anti-EpCAM x anti-CD3 bispecific antibody, M701, for the treatment of malignant pleural effusion due to NSCLC: A prospective randomized controlled phase II trial.

Zhengbo Song, Jun Cai, Dongqing Lv, Tienan Yi et autres

12061 Background: Malignant Pleural Effusion (MPE) is a common complication in patients with advanced NSCLC, associated with poor prognosis, severe symptoms, and reduced quality of life. Indwelling pleural catheter (IPC) is the first-line recommended therapy to alleviate MPE-related symptoms; however, no effective …

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Abstract CT036: A first-in-human study result of a novel EGFR-targeted antibody drug conjugate (ADC) in patients with advanced nasopharyngeal carcinoma (NPC) (SYS6010-001-NPC)

Haiqiang Mai, Linquan Tang, Xicheng Wang, Shaojun Lin et autres

Abstract Background: SYS6010 is a novel EGFR-targeted ADC, consisting of a humanized anti-EGFR mAb linked to a topoisomerase I inhibitor (JS-1) via a glycine̶̶-glycine-phenylalanine-glycine tetrapeptide linker (DAR = 8). This phase I study (ChiCTR2300072141) evaluated SYS6010 in advanced solid tumors, with NPC …

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Mechanism of horizontal transmission of tet(A)TIG multicopy structures in Escherichia coli of chicken origin

Chenhui Zou, Chunyan Xu, Yanhong Shang, Runhao Yu et autres

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A novel lysin Ply691 exhibits potent bactericidal activity against Streptococcus suis

Yanhong Shang, Xinyi Li, Shihang Ren, Chunying Du et autres

Introduction Streptococcus suis represents a growing zoonotic pathogen, exacerbated by increasing antimicrobial resistance due to a widespread and often inappropriate antimicrobial use. This escalating challenge underscores the pressing need for innovative treatment strategies against streptococcal infections in pigs. In our study, we …

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Characterization of lincomycin resistance gene lnu(C)-carrying Campylobacter jejuni

Wen‐Jun Li, Shengxiang Ge, Yong Liu, Hao Li et autres

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Abstract CT008: First-in-human study of SYS6010, a novel EGFR targeting antibody drug conjugate (ADC) for patients with advanced solid tumors

Shun Lu, Zhen Zhou, Ziming Li, Zhiyong He et autres

Abstract Background: SYS6010 is a novel ADC comprising of an anti-epidermal growth factor receptor (EGFR) humanized IgG1 monoclonal antibody conjugated to topoisomerase I inhibitor JS-1 via a cleavable glycine̶̶-glycine-phenylalanine-glycine tetrapeptide linker. Methods: This multicenter, open-label, phase 1 study evaluated the safety, tolerability …

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Expert consensus on the diagnosis and treatment of non-small cell lung cancer with MET alteration

Huijing Feng, Yang Xia, Wenxian Wang, Chunwei Xu et autres

Alterations in the mesenchymal-epithelial transition factor (MET) gene are critical drivers of non-small cell lung cancer (NSCLC). In recent years advances in precision therapies targeting MET alterations have significantly expanded treatment options for NSCLC patients. These alterations include MET exon 14 skipping …

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Glecirasib in KRASG12C-mutated nonsmall-cell lung cancer: a phase 2b trial

Yuankai Shi, Jian Fang, Ligang Xing, Yu Yao et autres

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poxtA amplification and mutations in 23S rRNA confer enhanced linezolid resistance in Enterococcus faecalis

Xinxin Shan, Chenglong Li, Likuan Zhang, Chenhui Zou et autres

OBJECTIVES: This study aimed to explore the evolutionary patterns and resistance mechanisms of an Enterococcus faecalis strain harbouring poxtA under linezolid exposure. METHODS: A poxtA-carrying E. faecalis electrotransformant DJH702 with a linezolid minimum inhibitory concentration of 4 mg/L was exposed to increasing …

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Comprehensive genomic profiling in solid tumors: Enhancing treatment selection and prognosis.

Minghui Wang, Yanhong Shang, Zhengang Yuan, Qing Hao et autres

e13631 Background: The emergence of novel therapeutic targets, targeted drugs, and immune checkpoint inhibitors has catalyzed a paradigm shift from single-target testing to comprehensive genomic profiling in the treatment of solid tumors. However, the tangible benefits of this shift in terms of …

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Prevalence and characterization of aminoglycoside resistance gene aph(2”)-If-carrying Campylobacter jejuni

Jin Han Kang, Cheng Zhang, Shuigen Wan, Wen‐Jun Li et autres

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Plasma proteome profiling reveals dynamic of cholesterol marker after dual blocker therapy

Jiacheng Lyu, Lin Bai, Yumiao Li, Xiaofang Wang et autres

Dual blocker therapy (DBT) has the enhanced antitumor benefits than the monotherapy. Yet, few effective biomarkers are developed to monitor the therapy response. Herein, we investigate the DBT longitudinal plasma proteome profiling including 113 longitudinal samples from 22 patients who received anti-PD1 …

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