Wei Wang

Carnosol inhibits influenza A virus by disrupting the viral envelope and interfering with Jak2/STAT3 signaling pathway

Lishan Sun, Yang Zhang, Can Xu, Zhongqiu Xu et autres

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NITR12+ NK Cells Release Perforin to Mediate IgMhi B Cell Killing in Turbot (Scophthalmus maximus)

Wei Wang, Ying Wang, Jin Yang, Qin Liu et autres

B lymphocytes engaged in humoral immunity play a critical role in combating pathogenic infections; however, the mechanisms of NK cells in regulating the responses of B cells remain largely unknown. In the present study, we established an Edwardsiella piscicida infection model in …

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[Analysis of teaching difficulties in the chapter of antigen in Medical Immunology and teaching strategy].

Kang Tang, Wei Wang, Rui Zhang, Yusi Zhang et autres

The concept of "ntigen"is a relative one. The narrow concept of it condenses the process of activation of adaptive immune response and re-recognition of the same antigen, revealing the protective mechanism of vaccines with great significance for research and development of vaccines. …

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Inhibition effects of patchouli alcohol against influenza a virus through targeting cellular PI3K/Akt and ERK/MAPK signaling pathways

Yunjia Yu, Yang Zhang, Shuyao Wang, Wei Liu et autres

BACKGROUND: Patchouli alcohol (PA) is a tricyclic sesquiterpene extracted from Pogostemonis Herba, which is a traditional Chinese medicine used for therapy of inflammatory diseases. Recent studies have shown that PA has various pharmacological activities, including anti-bacterial and anti-viral effects. METHODS: In this …

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Mutations That Increase the Stability of the Postfusion gp41 Conformation of the HIV-1 Envelope Glycoprotein Are Selected by both an X4 and R5 HIV-1 Virus To Escape Fusion Inhibitors Corresponding to Heptad Repeat 1 of gp41, but the gp120 Adaptive Mutations Differ between the Two Viruses

Min Zhuang, Russell Vassell, Yuan Chen, Paul W. Keller et autres

HIV-1 fuses with cells when the gp41 subunit of Env refolds into a 6HB after binding to cellular receptors. Peptides corresponding to HR1 or HR2 interrupt gp41 refolding and inhibit HIV infection. Previously, we found that a CCR5 coreceptor-tropic HIV-1 acquired a …

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Aloe Polysaccharides Inhibit Influenza A Virus Infection—A Promising Natural Anti-flu Drug

Zhenhong Sun, Cuilian Yu, Wei Wang, Guangfu Yu et autres

Influenza A virus causes periodic outbreaks and seriously threatens human health. The drug-resistant mutants have shown an epidemic trend because of the abuse of chemical drugs. Aloe polysaccharides extracted from Aloe vera leaves have evident effects on the therapy of virus infection. …

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Interferon-α-induced CD100 on naïve CD8 + T cells enhances antiviral responses to hepatitis C infection through CD72 signal transduction

Bing Jie Li, Yu He, Ying Zhang, Yong Hong Guo et autres

Objectives We investigated the effects of CD100 on naïve CD8 + T cells during hepatitis C virus (HCV) infection after interferon-α (IFN-α) therapy to clarify the mechanism underlying the effect of IFN-α in enhancing the antiviral response. Methods The CD100 molecules on …

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Measurement of Nightmare Experience, and its Application in Research and Treatment of Psychiatric Disorders

Wei Wang, Jiawei Wang

Nightmares are typically extended, elaborate dream narratives, and usually occur during rapid eye movement period of sleep.Nightmare experience is accompanied by the disturbed affect culminating in arousal, which usually involves an individual's efforts to avoid threats to survival, security, or physical integrity, …

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Immunogens Modeling a Fusion-Intermediate Conformation of gp41 Elicit Antibodies to the Membrane Proximal External Region of the HIV Envelope Glycoprotein

Russell Vassell, Yong He, Antu Dey, Min Zhuang et autres

The membrane proximal external region (MPER) of the gp41 subunit of the HIV-1 envelope glycoprotein (Env) contains determinants for broadly neutralizing antibodies and has remained an important focus of vaccine design. However, creating an immunogen that elicits broadly neutralizing antibodies to this …

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Chimeric influenza-virus-like particles containing the porcine reproductive and respiratory syndrome virus GP5 protein and the influenza virus HA and M1 proteins

Chunyi Xue, Wei Wang, Qiliang Liu, Zhongwei Miao et autres

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Trimeric, Coiled-coil Extension on Peptide Fusion Inhibitor of HIV-1 Influences Selection of Resistance Pathways

Min Zhuang, Wei Wang, Christopher J. De Feo, Russell Vassell et autres

Peptides corresponding to N- and C-terminal heptad repeat regions (HR1 and HR2, respectively) of viral fusion proteins can block infection of viruses in a dominant negative manner by interfering with refolding of the viral HR1 and HR2 to form a six-helix bundle …

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Selection with a Peptide Fusion Inhibitor Corresponding to the First Heptad Repeat of HIV-1 gp41 Identifies Two Genetic Pathways Conferring Cross-Resistance to Peptide Fusion Inhibitors Corresponding to the First and Second Heptad Repeats (HR1 and HR2) of gp41

Wei Wang, Christopher J. De Feo, Min Zhuang, Russell Vassell et autres

We generated four HIV-1 cultures that are resistant to a peptide fusion inhibitor corresponding to the first heptad repeat of gp41 in order to study mechanisms of resistance and gain insights into envelope glycoprotein-mediated membrane fusion. Two genetic pathways emerged that were …

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