Qian Wen

A novel natural compound from Cleistocalyx operculatus enhances the anti-mycobacterial response by inhibiting ferroptosis

Ke Wang, Xue Li, Wenxin Huang, Jianguo Song et autres

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Phosphorylation of dynamin-related protein 1 at Ser616 promotes autophagy to suppress Mycobacterium tuberculosis survival via the ROS/HIF-1α axis in macrophages

Qianna Li, Qi Wang, Binchi Mo, Bo Zhu et autres

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Effects of preoperative anti-PD-1 therapy on intraoperative and postoperative analgesia in patients undergoing radical esophagectomy: a retrospective cohort study

Yiwen Yang, Meng Yuan, Qian Wen, Mengru Wu et autres

The purpose of this study was to retrospectively investigate the impact of anti-programmed death-1 (anti-PD-1) immunotherapy on the analgesic efficacy of opioids during and after open radical esophagectomy. A retrospective study was conducted on 305 patients who underwent radical esophagectomy between September …

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Selenoprotein P deficiency drives hepatocellular carcinoma progression via induction of neutrophil senescence and immunosuppressive microenvironment

Jiazheng Jiao, Lele Song, Shengjun Xu, Yuan Xue et autres

BACKGROUND: The hepatocellular carcinoma (HCC) immune microenvironment is heavily influenced by immunosuppressive neutrophils, yet the mechanisms driving their senescence-associated reprogramming remain elusive. OBJECTIVES: To elucidate the role of Selenoprotein P (Sepp1)-mediated selenium metabolism in driving the accumulation and immunosuppressive function of senescent-like …

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Self-propelled biohybrids co-deliver oxaliplatin and glucose oxidase for multimodal treatment of colon cancer

Hongjun Deng, Shilin Xu, Kang Xiong, Qian Wen et autres

As a frontline chemotherapeutic agent for colorectal cancer, oxaliplatin (OXA) exhibits significantly reduced therapeutic efficacy and may induce severe adverse effects, primarily due to limited targeting capacity and impaired drug penetration within the hypoxic tumor microenvironment (TME). To address this challenge, an …

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AF6 regulates intestinal IgA via crosstalk between intestinal epithelial cells and immune cells in inflammatory bowel disease

Liying Lu, Keying Xu, Huiheng Qu, Lele Song et autres

The pathogenic factors of inflammatory bowel disease (IBD) are very complex, and further investigation of its pathogenesis is necessary. Some polar proteins have been reported to perform functions other than maintaining cell structure. In this study, we reported that the polar protein …

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Correction to “Bioactive Bacteria/MOF Hybrids Can Achieve Targeted Synergistic Chemotherapy and Chemodynamic Therapy Against Breast Tumors”

Jianmei Li, Jie Dai, Ling Zhao, Sheng Lin et autres

Hyaluronic acid modified metal-organic frameworks loading cisplatin achieve combined chemodynamic therapy and chemotherapy for lung cancer

Qian Wen, Jianmei Li, Hongjun Deng, Biqiong Wang et autres

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The microenvironment cell index is a novel indicator for the prognosis and therapeutic regimen selection of cancers

Xianyan Yang, Nian Chen, Qian Wen, Yu Zhou et autres

It is worthwhile to establish a prognostic prediction model based on microenvironment cells (MCs) infiltration and explore new treatment strategies for triple-negative breast cancer (TNBC). The xCell algorithm was used to quantify the cellular components of the TNBC microenvironment based on bulk …

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Multifunctional Three-Dimensional Polymer-Mediated Defect Passivation Enabling Efficient and Stable Inverted Inorganic Cspbi2br Perovskite Solar Cells

Xingyu Pu, Minmin Zhu, Qian Wen, Lin Zhang Yang et autres

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Nanoparticle‐Based drug delivery strategies for targeted therapy to hypoxic solid tumors

Zhouxue Wu, Junru Chen, Biqiong Wang, Qian Wen et autres

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A novel nonsense mutation c.747C>G in the NEUROD1 gene detected within a Chinese family affected by maturity‐onset diabetes of the young type 6

Yuwen Li, Qian Wen, Huige Shao, Yihu Sun et autres

Highlights Maturity-onset diabetes of the young type 6 (MODY6) is a rare form of monogenic diabetes mellitus due to NEUROD1 gene mutation on chromosome 2q32. A 21-year-old woman exhibiting weight loss, polyuria, and hyperglycemia was initially misdiagnosed with type 1 diabetes mellitus. …

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