Junfeng Jia

Predictive Value of Machine Learning in Knee Osteoarthritis Progression: Systematic Review and Meta-Analysis

Yanwen Liu, Guangzhi Xiao, Youqun Zhang, Xinyi Wang et autres

Background: Machine learning (ML) has been investigated for its predictive value in knee osteoarthritis (KOA) progression. However, systematic evidence on the effectiveness of ML is still lacking, posing a challenge to precision prevention. Objective: This systematic review aimed to systematically assess the …

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A Lung Ultrasound Score for Assessing Connective Tissue Disease‐Related Interstitial Lung Disease: Performance and Comparison With Computed Tomography Quantification

Ying Zhang, Linxuan Pang, Ning Guo, Wenjuan Wang et autres

BACKGROUND AND OBJECTIVE: The role of lung ultrasound's (LUS) in diagnosing and assessing connective tissue disease (CTD)-related interstitial lung disease (ILD) remains controversial. We aimed to evaluate the diagnostic performance of a quantitative LUS score and the correlations between LUS scores and …

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A regional ground-motion model for vertical-to-horizontal spectral acceleration ratios in Southwestern China

Shengcai Li, Lei Zhang, Junfeng Jia

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Meplazumab, a CD147 antibody, for severe COVID-19: a double-blind, randomized, placebo-controlled, phase 3 clinical trial

Huijie Bian, Chen Liang, Zheng Zhang, Aidong Wen et autres

Meplazumab, a humanized CD147 antibody, showed favorable safety and clinical benefits in phase 1 and phase 2/3 seamless clinical studies. Further evaluation of its therapeutic efficacy in patients with severe COVID-19 is needed. In this phase 3 add-on study, we randomized patients …

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Development of a risk prediction model for the first occurrence of thrombosis in patients with OAPS

Jie Gao, Yan Zheng, Zhuo Wang, Junfeng Jia et autres

Objectives: The aim of this study is to assess the risk factors associated with thrombotic events in obstetric antiphospholipid syndrome (OAPS) patients and to develop a predictive model specifically tailored to predict the risk of postpartum thrombosis in OAPS patients without prior …

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Prediction of prognosis in patients with systemic sclerosis based on a machine-learning model

Yan Zheng, Wei Jin, Kui Zhang, Junfeng Jia et autres

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CD147 regulates the formation and function of immune synapses

Yunpeng Xu, Kui Zhang, Jinlin Miao, Na Guo et autres

CD147 is a T cell activation-associated molecule which is closely involved in the formation of the immune synapse (IS). However, the precise role of CD147 in T cell activation and IS formation remains unclear. In the present study, we demonstrated that CD147 …

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Network pharmacology-based analysis on geniposide, a component of gardenia jasminoides, beneficial effects to alleviate LPS-induced immune stress in piglets

Zhuorui Shan, Junfeng Jia, Qiuju Wang, Yizhe Cui

Geniposide is the main medicinal component of Gardenia jasminoides, and its content is approximately 3-8% depending on its origin. Geniposide is a class of cyclic enol ether terpene glucoside compounds with strong antioxidant, free radical quenching and cancer-inhibiting activities. Many studies have …

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Meplazumab in hospitalized adults with severe COVID-19 (DEFLECT): a multicenter, seamless phase 2/3, randomized, third-party double-blind clinical trial

Huijie Bian, Liang Chen, Zhaohui Zheng, Xiuxuan Sun et autres

Meplazumab, a humanized CD147 antibody, has shown favourable safety and efficacy in our previous clinical studies. In DEFLECT (NCT04586153), 167 patients with severe COVID-19 were enroled and randomized to receive three dosages of meplazumab and a placebo. Meplazumab at 0.12 mg/kg, compared …

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Case report: Kimura's disease with minimal degenerative glomerulopathy without eosinophil infiltration responds to mycophenolate mofetil treatment

Qing Han, Jie Han, W. T. Wang, Jie Gao et autres

Kimura's disease (KD) is a rare chronic progressive immune inflammatory disease. The etiology is unknown and manifests as a chronic inflammatory process, which is more common in young Asian men. The clinical manifestations are painless subcutaneous swelling of the head and neck …

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Current situation of acute ST-segment elevation myocardial infarction in a county hospital chest pain center during an epidemic of novel coronavirus pneumonia

Feng Li, Rong Luo, Xiaoting Wang, Junfeng Jia et autres

Abstract Our object was to examine how the pre- and post-pandemic COVID-19 impacted the care of acute ST-segment elevation myocardial infarction (STEMI) patients in county hospitals. Using January 20, 2020, as the time point for the control of a unique coronavirus pneumonia …

Investigation and Analysis of Anxiety and Quality of Life among Systemic Lupus Erythematosus Patients in Northwestern China

Qing Wang, Junfeng Jia, Kui Zhang, Zhaohui Zheng et autres

The aim of this study was to provide targeted psychological support and effective nursing for systemic lupus erythematosus (SLE) patients. SLE is a complex, systemic autoimmune disease characterized by recurrent episodes and the involvement of multiple organs. With improvements in SLE treatment …

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