Isao Ono

Progressive occlusion of the middle cerebral artery as the main feeder in a cerebral arteriovenous malformation: A case report

Takaaki Kitano, Shu Takeuchi, Isao Ono, Hideo Chihara

Background: Cerebral arteriovenous malformation (AVM) is a congenital condition characterized by abnormal direct connections between arteries and veins through a nidus. Occlusion of major feeding arteries in AVMs is rare and typically associated with moyamoya disease. To date, only three cases have …

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Potential of the pharmacological inhibition of CCL2-CCR2 axis via targeting FROUNT to prevent the initiation and the progression of intracranial aneurysms in rats

Isao Ono, Masahiko Itani, Akihiro Okada, Akitsugu Kawashima et autres

Intracranial aneurysms (IAs) affect 1%-5% of the public and are a major cause of subarachnoid hemorrhage. Currently, there is no medical treatment to prevent the progression or rupture of IAs. Recent studies have defined IA as a chronic inflammatory disease in which …

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Spontaneous Cerebrospinal Fluid Rhinorrhea With Meningoencephalocele Recurrence After Placement of a Lumboperitoneal Shunt: A Case Report

Hiroki Natsuhara, Hideo Chihara, Isao Ono

Cerebrospinal fluid rhinorrhea associated with meningoencephalocele is usually treated surgically. During the perioperative period, cerebrospinal fluid diversion may be employed to control intracranial pressure, but there are few indications for this method. A 51-year-old female presented with cerebrospinal fluid rhinorrhea associated with …

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Predictors of aneurysm shrinkage after flow diversion treatment for internal carotid artery aneurysms: quantitative volume analysis with MRI

Ryo Akiyama, Akira Ishii, Takayuki Kikuchi, Masakazu Okawa et autres

Background and purpose Although aneurysm shrinkage often occurs after flow diversion treatment for intracranial aneurysms, no reports have addressed the factors associated with aneurysm shrinkage. Materials and methods This retrospective single-center study was performed to examine patients with unruptured internal carotid artery …

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Hemodynamic force as a potential regulator of inflammation-mediated focal growth of saccular aneurysms in a rat model

Kampei Shimizu, Hiroharu Kataoka, Hirohiko Imai, Yuto Yamamoto et autres

【背景】過去の研究より，脳動脈瘤増大機序において，マクロファージ依存的な慢性炎症が，重大な役割を果たしていることが明らかにされてきた．血行力学応力もまた，脳動脈瘤増大のトリガーであることが考えられてきたが，その機序は明らかにされていない．

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Hypoxic microenvironment as a crucial factor triggering events leading to rupture of intracranial aneurysm

Isao Ono, Tomomichi Kayahara, Akitsugu Kawashima, Akihiro Okada et autres

Subarachnoid hemorrhage being the rupture of intracranial aneurysm (IA) as a major cause has quite poor prognosis, despite the modern technical advances. Thereby, the mechanisms underlying the rupture of lesions should be clarified. Recently, we and others have clarified the formation of …

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Endothelial cell malfunction in unruptured intracranial aneurysm lesions revealed using a 3D-casted mold

Isao Ono, Yu Abekura, Akitsugu Kawashima, Mieko Oka et autres

Intracranial aneurysms (IA) are major causes of devastating subarachnoid hemorrhages. They are characterized by a chronic inflammatory process in the intracranial arterial walls triggered and modified by hemodynamic force loading. Because IA lesion morphology is complex, the blood flow conditions loaded on …

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Identification of The Unique Subtype of Macrophages in Aneurysm Lesions at the Growth Phase

Akihiro Okada, Hirokazu Koseki, Isao Ono, Tomomichi Kayahara et autres

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Onset-to-treatment time and aneurysmal regression predict improvement of cranial neuropathy after flow diversion treatment in patients with symptomatic internal carotid artery aneurysms

Ryo Akiyama, Akira Ishii, Takayuki Kikuchi, Masakazu Okawa et autres

BACKGROUND: Although flow diversion plays a pivotal role in treating internal carotid artery aneurysms presenting with cranial neuropathy, predictors of symptom improvement have not been established. OBJECTIVE: To investigate improvement of symptoms after flow diversion treatment in patients with internal carotid artery …

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Identification of the unique subtype of macrophages in aneurysm lesions at the growth phase

Akihiro Okada, Hirokazu Koseki, Isao Ono, Tomomichi Kayahara et autres

Abstract Background Considered with the devastating outcome of subarachnoid hemorrhage due to rupture of intracranial aneurysm (IA), a novel therapeutic strategy based on the pathogenesis of IAs should be established. Recent experimental studies have defined IAs as a macrophage-mediated chronic inflammatory disease …

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Hypoxic microenvironment as a crucial factor triggering events leading to rupture of intracranial aneurysm

Isao Ono, Tomomichi Kayahara, Akitsugu Kawashima, Akihiro Okada et autres

Abstract Subarachnoid hemorrhage being the rupture of intracranial aneurysm (IA) as a major cause has a high mortality rate. It is thus mandatory for social health to clarify mechanisms regulating rupture of IAs and to develop a novel therapeutic strategy. Recently, the …

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Hypoxic microenvironment as a crucial factor triggering events leading to rupture of intracranial aneurysm

Tomohiro Aoki, Isao Ono, Tomomichi Kayahara, Akitsugu Kawashima et autres

Abstract Background: Subarachnoid hemorrhage being the rupture of intracranial aneurysm (IA) as a major cause has a high mortality rate in spite of technical advancement in treatment interventions. Thereby, it is mandatory for social health to clarify mechanisms regulating rupture of IAs …

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