José Agapito Fonseca

Living after acute kidney injury: understanding the physical and psychosocial consequences

Joana Gameiro, José Agapito Fonseca, José António Lopes

PURPOSE OF REVIEW: Acute kidney injury (AKI) is increasingly recognized as a condition with important long-term consequences, beyond kidney specific outcomes. This review addresses the growing population of AKI survivors and the need to better understand outcomes that matter to patients, which …

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Mais do que aparenta: um caso de síndrome de nefrite tubulointersticial e uveíte

Telma Pais, Nadiesda Peres, Miguel Ángel Santos, Inês Leal et autres

RESUMO A síndrome de nefrite tubulointersticial e uveíte (TINU) é uma patologia inflamatória oculorrenal rara, caracterizada pela ocorrência concomitante de nefrite tubulointersticial (NTI) e uveíte, na ausência de outra doença sistêmica que justifique ambas as manifestações. Apresentamos o caso de uma mulher …

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More than meets the eye: a case of tubulointerstitial nephritis and uveitis syndrome

Telma Pais, Nadiesda Peres, Miguel Ángel Santos, Inês Leal et autres

Tubulointerstitial nephritis with uveitis (TINU) syndrome is a rare oculorenal inflammatory disorder characterized by concurrent tubulointerstitial nephritis (TIN) and uveitis in the absence of an alternative systemic disease. We present a 57-year-old woman with acute kidney injury, euglycemic glycosuria, and simul-taneous non-granulomatous …

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External validation of a predictive model for one-year mortality in incident hemodialysis patients: A Portuguese cohort

Telma Pais, Beatriz Teixeira, Miguel Carrilho, José Agapito Fonseca et autres

BACKGROUND: Prognostic assessment after starting hemodialysis is challenging, with mortality in the first year estimated to be 15%. Clark et al. developed the Recovery and Death Outcome risk score, which accurately predicted the likelihood of renal recovery to dialysis independence and of …

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Anotação de lactonas sesquiterpênicas em Baccharis pentlandii

Lorena de Mendonça Lucena, José Agapito Fonseca, Gustavo Heiden, Jorge Luiz Silveira Sonego et autres

A família Asteraceae é uma das mais numerosas do reino vegetal, reunindo cerca de 1.700 gêneros e mais de 24.000 espécies espalhadas por diversos ecossistemas do mundo.Dentro dessa diversidade, destacase o gênero Baccharis, nativo das Américas e composto por aproximadamente 500 espécies, …

External validation of a predictive model for one-year mortality in incident hemodialysis patients: a Portuguese cohort

Telma Pais, Beatriz Teixeira, Miguel Carrilho, José Agapito Fonseca et autres

Background: Prognostic assessment after starting hemodialysis is challenging, with mortality in the first year estimated to be 15%. Clark et al. developed the Recovery and Death Outcome risk score, which accurately predicted the likelihood of renal recovery to dialysis independence and of …

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The burden of acute kidney disease: an epidemiological review and importance of follow-up care

Joana Gameiro, Beatriz Tomé Gouveia, José Agapito Fonseca, José António Lopes

Acute kidney injury (AKI) is a common and serious medical condition with increasing incidence over the past few decades. Patients with AKI undergo various clinical trajectories and they are at high risk of progression to chronic kidney disease (CKD). Acute kidney disease …

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Long-term outcomes after AKI in hospitalized patients with COVID-19

Bernardo Marques da Silva, Joana Gameiro, Joana Lei Teixeira, Cláudia Costa et autres

Acute kidney injury (AKI) is frequent in hospitalized patients and contributes to adverse short- and long-term outcomes. We aimed to evaluate the association of AKI and long-term adverse renal events and mortality in a cohort of patients hospitalized with COVID-19. Single-center and …

CHEMICAL DIFFERENTIATION BETWEEN BACCHARIS TRIMERA (LESS.) DC AND BACCHARIS MICROCEPHALA (LESS.) DC USING UNTARGETED METABOLOMIC ANALYSIS

Renally Cristina Lima da Silva, Lorena de Mendonça Lucena, Diana Lopes da Silva, Vitória Cristina Pontes de Queiroz et autres

This study used untargeted metabolomics and mass spectrometry to chemically distinguish Baccharis trimera from Baccharis microcephala, identifying a unique triterpene marker (m/z 597.4505) for quality control of B. trimera. The findings provide a practical approach for species differentiation and improved quality assurance …

ANNOTATION OF COMPOUNDS PRESENT IN BACCHARIS TRIMERA AND BACCHARIS CRISPA USING THE GNPS PLATFORM

Lorena de Mendonça Lucena, Renally Cristina Lima da Silva, Diana Lopes da Silva, Vitória Cristina Pontes de Queiroz et autres

This study used metabolomics and mass spectrometry to differentiate Baccharis trimera from Baccharis crispa, identifying key chemical profiles and molecular networks, particularly in flavonoid compounds. The findings highlight the potential for improved quality control of B. trimera through further dereplication of uncharacterized …

Autosomal Dominant Tubulointerstitial Kidney Diseases

Telma Pais, Marilene Gasparin Rodrigues, José Agapito Fonseca, Iolanda Godinho et autres

Background: Autosomal dominant tubulointerstitial kidney diseases (ADTKD) are characterized by chronic interstitial nephritis and mutations in UMOD, MUC1, REN, and HNF1Bgenes have been implicated. Advances in molecular diagnostics have improved the diagnosis of ADTKD. We aimed to characterize the patients evaluated for …

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Long-term outcomes after AKI in hospitalized patients with COVID-19

Bernardo Marques da Silva, Joana Gameiro, Joana Lei Teixeira, Cláudia Costa et autres

Acute kidney injury (AKI) is frequent in hospitalized patients and contributes to adverse short- and long-term outcomes. We aimed to evaluate the association of AKI and long-term adverse renal events and mortality in a cohort of patients hospitalized with COVID-19. Single-center and …