Prabhjot Kaur

Targeting cellular senescence alleviates bone marrow aging

Bowen Yan, Jin Han, Yang Yang, Peiyi Zhang et autres

Aging of the hematopoietic system impairs hematopoietic stem cell (HSC) function and alters bone marrow niche behavior, increasing susceptibility to anemia, infections, and hematologic malignancies. Here, pharmacologic clearance of senescent cells with the PROTAC compound 753b simultaneously targeting BCL-xL and BCL-2 reverses …

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83. Genome-wide structural variant identification in fresh frozen tissues using optical genome mapping

S. Sathyanarayana, Alyssa C. Caiati, Chun‐Chieh Lin, Joel A. Lefferts et autres

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Epigenetic basis of MDS/MPN overlap syndrome with compound loss of Kmt2c and Dnmt3a

Prabhjot Kaur, Jixiu Shan, Kalyanee Shirlekar, Erin C Hayslip et autres

Abstract Monosomy 7, or loss of 7q (-7/del(7q)), is one the most common chromosomal anomalies in myelodysplastic syndromes (MDS, ~10% of patients), a malignant disorder of the blood system with few treatment options. There are currently no targeted therapies available for -7/del(7q) …

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DNMT3A-driven clonal hematopoiesis permits colitis-associated tumorigenesis by promoting innate immune tolerance

Qingchen Yuan, Yang Feng, Christopher Thai, Eric Y. Helm et autres

Abstract Clonal hematopoiesis (CH), defined as an expanded hematopoietic stem cell (HSC) clone with somatic mutations in the absence of blood malignancy, is common in aging and associated with increased severity of inflammatory non-hematologic disorders. The co-occurrence of CH in patients with …

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Clonal hematopoiesis driven by Dnmt3a mutations promotes metabolic disease development in mice

Bowen Yan, Qingchen Yuan, Marco M. Buttigieg, Prabhjot Kaur et autres

Clonal hematopoiesis (CH) is associated with an increased risk of non-hematologic chronic diseases including metabolic disorders, yet the causality remains poorly defined.DNMT3A is the most altered gene in CH, commonly through monoallelic loss-of-function (LOF) and Arg882His (RH) mutations.Here we demonstrate in a …

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Feasibility and Acceptability of Noninvasive Stool Testing for Surveillance of Colorectal Polyps in Older Adults

S Luft, Mirjana Stevanovic, Christopher M. Navas, Douglas J. Robertson et autres

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Clonal hematopoiesis driven by Dnmt3a mutations promotes metabolic disease development

Bowen Yan, Qingchen Yuan, Prabhjot Kaur, Annalisse Mckee et autres

Clonal hematopoiesis (CH) is associated with an increased risk of non-hematologic chronic diseases including metabolic disorders, yet the causality remains poorly defined. DNMT3A is the most frequently altered gene in CH, commonly through monoallelic loss-of-function (LOF) and Arg882His (RH) hotspot mutations. Here …

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Is GenAI Really the Future of this World: Dark Side of GenAI

Prabhjot Kaur, Anupama Kaushik, Khushi Sehrawat, Preeti Singh

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Clonal Hematopoiesis Driven By Mutations in DNMT3A Promotes Metabolic Disease

Bowen Yan, Qingchen Yuan, Prabhjot Kaur, Annalisse Mckee et autres

Background: Clonal hematopoiesis (CH) is characterized by the clonal expansion of hematopoietic stem cells (HSCs) marked with somatic mutations and of their progeny in the absence of quantitative blood abnormalities. In addition to an elevated risk of developing blood malignancies, CH is …

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Exploring the Influence of Change of Land Use on Place Identity

Swati Behl, Prabhjot Kaur

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Decoding the identity of rare tumors

Qingchen Yuan, Prabhjot Kaur, Olga A. Guryanova

Solitary fibrous tumors have gene expression signatures similar to those of neuroendocrine tumors.

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Compound Loss of Dnmt3a and Kmt2c in Myeloid Malignancies

Prabhjot Kaur, Cassandra M. Berntsen, James Leonard, Daniil E. Shabashvili et autres

Monosomy 7, or loss of 7q (-7/del(7q)), is one the most common chromosomal anomalies in myelodysplastic syndromes (MDS, ~10% of patients), a malignant disorder of the blood system with few treatment options. There are currently no targeted therapies available for -7/del(7q) MDS, …

us (code pays fourni par la source)