Yue-chao Fan

Development and validation of a prognostic nomogram for predicting outcomes in brainstem hemorrhage patients

Shuo Wei, Longyuan Gu, Yue-chao Fan, Ping Ji et autres

Brainstem hemorrhage is a severe neurological condition with high mortality and poor prognosis. This study aims to develop and validate a prognostic model for brainstem hemorrhage to facilitate early prediction of patient outcomes, thereby supporting clinical decision-making. Clinical data from 140 patients …

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SRBD1 Regulates the Cell Cycle, Apoptosis, and M2 Macrophage Polarization via the RPL11‐MDM2‐p53 Pathway in Glioma

Hongfu Chen, Shuping Gao, Peng Wang, Manyi Xie et autres

Low expression of certain ribosomal proteins leads to the inactivation of p53, which is mediated mainly by RPL5 or RPL11 (ribosomal protein L11). It is also unknown what mechanisms drive aberrant ribosomal proteins expression in tumor. SRBD1 (S1 RNA-binding domain 1), as …

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Diagnosis and surgical treatment strategies for spinal extradural arachnoid cyst: Case report and treatment insights

Longyuan Gu, Shuhong Mei, Yue-chao Fan, Hui Zhang et autres

INTRODUCTION: Spinal extradural arachnoid cyst (SEAC) is a rare condition that can cause significant neurological symptoms. Accurate diagnosis and effective surgical treatment are crucial for patient recovery. This study aims to elucidate the diagnostic process and surgical treatment strategies for SEAC through …

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Machine learning predictors of risk of death within 7 days in patients with non-traumatic subarachnoid hemorrhage in the intensive care unit: A multicenter retrospective study

Longyuan Gu, Hongwei Hu, Shi‐Nan Wu, Fengda Li et autres

Non-traumatic subarachnoid hemorrhage (SAH) is a critical neurosurgical emergency with a high mortality rate, imposing a significant burden on both society and families. Accurate prediction of the risk of death within 7 days in SAH patients can provide valuable information for clinicians, …

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Machine learning-based prediction of cerebral hemorrhage in patients with hemodialysis: A multicenter, retrospective study

Fengda Li, Anmin Chen, Zeyi Li, Longyuan Gu et autres

Background: Intracerebral hemorrhage (ICH) is one of the most serious complications in patients with chronic kidney disease undergoing long-term hemodialysis. It has high mortality and disability rates and imposes a serious economic burden on the patient's family and society. An early prediction …

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CSF Biopsy in Glioma: A Brief Review

Heng Jia, Hui Zhang, Faan Miao, Lu Dong et autres

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KIF4A drives gliomas growth by transcriptional repression of Rac1/Cdc42 to induce cytoskeletal remodeling in glioma cells

Hui Zhang, Sen Meng, Kun Chu, Sufang Chu et autres

Glioma is one of the most prevalent cancers diseases in the worldwide.Kinesin superfamily protein 4 (KIF4), a KIF member classified in Kinesin 4 has been indicated as a mediator acted in tumorigenesis of human cancer.However, the mechanism of KIF4A on glioma is …

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Vitamin C through upregulating SYNPO2 level suppresses the proliferation and migration of glioma cells.

Yi-Shuo Zhu, Xuan Wang, Yujie Cui, Jin Bai et autres

PURPOSE: The aim was to demonstrate the progression of glioma influenced by Vitamin C (VC) and the potential molecular mechanism. METHODS: Proliferative and migratory rates of U87 and U251 cells induced with 0, 50 and 100 µM VC were examined by CCK-8 …

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Rap2B promotes cell adhesion, proliferation, migration and invasion of human glioma

Faan Miao, Chenchen Cui, Dandan Zuo, Hui Zhang et autres

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CTHRC1 mediates multiple pathways regulating cell invasion, migration and adhesion in glioma.

Peng-jin Mei, Jin Bai, Faan Miao, Chen Chen et autres

test). Furthermore, Knockdown of CTHRC1 suppressed glioma cell invasion and inhibited enzyme activity of MMP-2. Moreover, our data showed that knockdown of CTHRC1 inhibited glioma cell migration and adhesion capacity when compared with the control cells, and CTHRC1-siRNA reduced the levels of …

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Overexpression of CAP1 and its significance in tumor cell proliferation, migration and invasion in glioma

Yue-chao Fan, Chenchen Cui, Yi-Shuo Zhu, Lei Zhang et autres

Adenylate cyclase-associated protein 1 (CAP1), a protein related to the regulation of actin filaments and the Ras/cAMP pathway, is associated with tumor progression. Nevertheless, the expression level and effects of CAP1 in regards to glioma have not been reported. In the present …

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腫瘍壊死因子受容体関連因子4がヒト脳神経膠腫細胞U87の増殖、遊走と浸潤に与える影響とその機序【JST・京大機械翻訳】

Meng Shi, Chenchen Cui, Zhang Lei, Yu Jinsong et autres