Davi J. A. Moraes

Electrophysiological properties of the dorsal motor nucleus of the vagus motoneurones controlling airway mucus secretion in rats

Daniel P. de Souza, Renato Willian Martins Sá, Luiza Henrique de Souza, Fernando S. Ramalho et autres

Abstract The parasympathetic efferent innervation to the respiratory airways controls bronchoconstriction and mucus secretion. It is known that the parasympathetic respiratory motoneurones (PRMNs) projecting to the airways are located in the nucleus ambiguus (NA) and dorsal motor nucleus of the vagus (DMV). …

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Lateral Parafacial Neurons Evoked Expiratory Oscillations Driving Neurogenic Hypertension

Karolyne S. Magalhães, Renato Willian Martins Sá, Nathalia Salim, Thaís Marques da Silva et autres

BACKGROUND: Hypertension is the single most important risk factor for cardiovascular diseases and remains poorly controlled. Currently, 40% of treated patients remain hypertensive. We propose that this is in part due to excessive sympathetic activity. We hypothesized that neuronal expiratory oscillations, in …

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Scalable Quantum Walk-Based Heuristics for the Minimum Vertex Cover Problem

F. S. Luiz, A. K. F. Iwakami, Davi J. A. Moraes, Maurı́cio C. de Oliveira

We propose a novel heuristic quantum algorithm for the Minimum Vertex Cover (MVC) problem based on continuous-time quantum walks (CTQWs). In this framework, the coherent propagation of a quantum walker over a graph encodes its structural properties into state amplitudes, enabling the …

COMPARATIVE STUDY OF META-HEURISTIC ALGORITHMS IN THE UAV-BS POSITIONING SOLUTION

Davi J. A. Moraes, Wilson A. Silva, Albert E. C. Santos, Matheus Gabriel Pantoja et autres

Unmanned Aerial Vehicles as Base Stations (UAV- BS) are capable of reestablishing user connectivity in natural disaster scenarios. Optimizing the positioning of UAV-BS presents significant challenges, including identifying the most suitable metaheuristic for implementation. This study proposes the eval- uation of five …

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Redefining respiratory sinus arrhythmia as respiratory heart rate variability: an international Expert Recommendation for terminological clarity

Clément Menuet, Alona Ben‐Tal, Ambre Linossier, Andrew M. Allen et autres

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Short-term sustained hypoxia distinctly affects subpopulations of carotid body glomus cells from rats

Pedro F. Spiller, Henrique J. N. Morgan, Luiz Carlos Carvalho Navegantes, Benedito H. Machado et autres

Our study revealed two subpopulations of glomus cells of carotid bodies (CBs) with specific electrophysiological properties, which were differentially affected by short-term sustained hypoxia (SH; 10% O 2 for 24 h). Our experiments showed that SH also affected the sensitivity to acute …

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Glutamatergic and purinergic transmitters and astrocyte modulation in the synaptic transmission in the NTS of rats exposed to short-term sustained hypoxia

Darlan S. Bazilio, Davi J. A. Moraes, Benedito H. Machado

Our findings indicate that the neurotransmission of autonomic and respiratory components of the peripheral chemoreflex in the nucleus tractus solitarius (NTS) is mediated by glutamatergic and purinergic mechanisms and reveal a selective involvement of NTS astrocytes in controlling the chemoreflex parasympathetic response …

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Electrophysiological Properties and Morphology of Cardiac and Pulmonary Motoneurons within the Dorsal Motor Nucleus of the Vagus of Rats

Júlia G.V. de Souza, Daniel P. de Souza, Carlos A. A. Silva, Renato Willian Martins Sá et autres

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Inhibition of somatostatinergic interneurons of the lateral parafacial region reduces the ventilatory response to hypercapnia of mice

Nathalia Salim, Karolyne Magalhães, Renato Duffles Martins, Davi J. A. Moraes

The lateral parafacial region (pFL), which contains excitatory and inhibitory neurons and interneurons, generates active expiration in response to hypercapnia. Inhibition of inhibitory somatostatinergic (Sst)-positive neurons in parafacial region increases pulmonary ventilation, while hypercapnia inhibits some of them intrinsically. However, the role …

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Forgotten Circulation: Reduced Mesenteric Venous Capacitance in Hypertensive Rats Is Improved by Decreasing Sympathetic Activity

Tonja W. Emans, Davi J. A. Moraes, Alona Ben‐Tal, Carolyn J. Barrett et autres

BACKGROUND: The mesenteric venous reservoir plays a vital role in mediating blood volume and pressure changes and is richly innervated by sympathetic nerves; however, the precise nature of venous sympathetic regulation and its role during hypertension remains unclear. We hypothesized that sympathetic …

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Electrophysiological properties and phenotype of the expiratory lateral parafacial neurons of rats

Karolyne Magalhães, Melina da Silva, André S. Mecawi, Julian F. R. Paton et autres

Active expiration is essential for increasing pulmonary ventilation during high chemical drive (hypercapnia). Several studies demonstrated that the lateral aspect of the parafacial (pFL) region, which contains expiratory neurons, drives abdominal muscles during active expiration in response to hypercapnia. However, the electrophysiological …

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What is the role of ATP in the hypertensive carotid body?

Igor Felippe, Dylan Pen, Aabharika Bose, Davi J. A. Moraes et autres

ATP acting on P2X2/3 receptors within carotid bodies (CBs) underpins chemoreflex hyperreflexia and hypertonicity of sympathetic activity in Spontaneously Hypertensive rats (SHR). As the exact mechanisms remain elusive, we hypothesized either a greater release and/or decreased breakdown of ATP in CBs of …

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