Qing Zhan

Case Report: Acute keratoconus as the presenting feature in undiagnosed Norrie disease: hypothesis from a novel NDP mutation

Xu Cao, Longhao Kuang, Jiexuan Lv, Shaoyi Mei et autres

Background Norrie disease is a rare X-linked recessive disorder characterized by congenital blindness, with approximately one-third of patients developing progressive sensorineural hearing loss and neurodevelopmental abnormalities. While over 200 pathogenic variants in the NDP gene have been identified, the phenotypic spectrum continues …

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Case Report: Post-LASIK exacerbation of granular corneal dystrophy type 2: a familial case with TGFBI mutation

Longhao Kuang, Xuanjun Zhang, Yufang Wang, Qing Zhan et autres

Purpose To demonstrate that LASIK is contraindicated in patients with granular corneal dystrophy through documentation of post-surgical disease exacerbation. Methods Comprehensive clinical evaluation including anterior segment photography and multimodal imaging were performed on the proband and affected family members. Genomic DNA was …

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Non-genitourinary Ureaplasma urealyticum infections in solid organ transplant recipients: a case report and literature review

Fang Wang, Qing Zhan, Hong Zhu, Lei Guo et autres

BACKGROUND: Ureaplasma urealyticum, a commensal organism, is potentially pathogenic. In solid organ transplant recipients, non-genitourinary U. urealyticum infection is associated with an increased risk of graft failure or death. RESULTS: We reported a case of mediastinitis caused by U. urealyticum in a …

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Optimization of environmental surveillance-driven carbapenem-resistant organisms infection prevention and control strategies in intensive care units: A 4-year multicampus prospective intervention study

Tianxiang Ge, Haiting Feng, Lingmei Ni, Fang Wang et autres

BACKGROUND: Carbapenem-resistant organisms (CROs) are among the most concerning antimicrobial resistance pathogens, especially in intensive care units (ICUs). The role of environmental contamination in the transmission of CROs has been increasingly recognized. The aim of this study was to establish a replicable …

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Severe Cerebral Venous Sinus Thrombosis and Deep Vein Thrombosis Induced by Non-Criteria aPI and aPS/PT Positive Antiphospholipid Antibodies: A Case Report and Mini Review

Yi He, Feng-Kun Zhang, Xiaoling Zhong, Shanni Ma et autres

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Chemically synthesized phosphorylated ubiquitin unlocks parkin for activation-controlled PROTAC platforms

Qing Zhan, Qian Qu, Siyi Cui, Yicheng Weng et autres

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Chemically Synthesized Phosphorylated Ubiquitin Unlocks Parkin for Activation-Controlled PROTAC Platforms

Qing Zhan, Qian Qu, Siyi Cui, Man Pan et autres

Proteolysis targeting chimeras (PROTACs) have been considered a promising therapeutic strategy, but their application is restricted by the limited number of available E3 ligases. Here, we expanded Parkin, an autoinhibitory E3 whose activity can be triggered by binding to its activating ligand, …

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Factors affecting meibomian gland area loss in symptomatic adults

Sicheng Ding, Qing Zhan, J T Wang, Fang Zheng et autres

AIM: To characterize the distribution of meibomian gland (MG) area loss (MGL) and its relationship with demographic characteristics, mites, and symptoms. METHODS: This retrospective observational study included patients who visited the Dry Eye Clinic of Shenzhen Eye Hospital between June 2020 and …

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Expression of ATP-Binding Cassette Transporter A1 (ABCA1) in Eyelid Tissues and Meibomian Gland Epithelial Cells

Fang Zheng, Jingjing Su, J T Wang, Qing Zhan et autres

Purpose: To validate the adenosine triphosphate (ATP)-binding cassette transporter A1 (ABCA1) expression and distribution in human eyelid tissues and meibomian gland epithelial cells. Methods: Meibomian gland tissues from human eyelids were isolated by collagenase A digestion and cultured in defined keratinocyte serum-free …

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High prevalence of ST5-SCCmec II-t311 clone of methicillin-resistant Staphylococcus aureus isolated from bloodstream infections in East China

Qing Zhan, Gaoqin Teng, Weiwei Chen, Xiao Yu

OBJECTIVES: Methicillin-resistant Staphylococcus aureus (MRSA) is a challenging global health threat, resulting in significant morbidity and mortality worldwide. This study aims to determine the molecular characteristics and antimicrobial susceptibility of 263 MRSA isolates in Zhejiang Province, east China. METHODS: From 2014 to …

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Promotion of Osseointegration Using a Titanium Oxide Nanotube Modified Biomimetic Nano-Structured Multi-Layer Implant

Xue-guan Xie, Hao Hu, Yankun Dai, Xu Huang et autres

Objective: Construction of a novel biomimetic nano-structured multi-layer interface implant to induce osseointegration. Methods: Spark plasma sintering was used to create micron-scale trabecular bone biomimicry structures, surface modification with TiO2 nanotubes, and micron-scale trabecular bone biomimicry/TiO2 nanotubes from pure titanium samples. The …

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Environmental Monitoring of Parvovirus B19 in the Kidney Transplantation Ward of a Chinese Teaching Hospital

Fang Wang, Qing Zhan, Shiping Yu, Haiting Feng et autres

Fang Wang,1,* Qing Zhan,1,* Shi-Ping Yu,2 Hai-Ting Feng,1 Ping Hu,2 Zi-Feng Zhong,1 Ting-Ting Qu1,3 1Infection Control Department, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, People’s Republic of China; 2Kidney Disease Center, The First Affiliated Hospital, Zhejiang University School …

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