Wenbin Zhao

Dual molecular and clinical machine-learning prognostic modeling in pancreatic ductal adenocarcinoma: a chaperone-mediated autophagy–based framework integrating multi-cohort molecular signatures and a single-center clinical nomogram

Qingyan Kou, Shengxian Qiao, Zhenyuan Liu, Zhichao Wu et autres

Background Pancreatic ductal adenocarcinoma (PDAC) is characterized by marked molecular, cellular, and clinical heterogeneity. Chaperone-mediated autophagy (CMA) supports adaptation to metabolic and environmental stress, but its cell type-specific distribution and prognostic relevance in PDAC remain unclear. Methods Single-cell RNA sequencing data from …

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Multi-omics analysis identifies SNP-associated immune-related signatures by integrating Mendelian randomization and machine learning in hepatocellular carcinoma

Qingyan Kou, Zhichao Wu, Wenbin Zhao, Zhenyuan Liu et autres

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death globally, characterized by high morbidity and poor prognosis. The complex molecular and immune landscape of HCC makes accurate patient stratification and personalized treatment essential. In this study, we utilized large-scale gene expression …

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The Abrolhos Nominally Herbivorous Coral Reef Fish Acanthurus chirurgus, Kyphosus sp., Scarus trispinosus, and Sparisoma axillare Have Similarities in Feeding But Species-Specific Microbiomes

Cristiane Thompson, Raphael Silva, Fernando Zaniolo Gibran, Leonardo Bachá et autres

Abstract Coral reefs rely heavily on reef fish for their health, yet overfishing has resulted in their decline, leading to an increase in fast-growing algae and changes in reef ecosystems, a phenomenon described as the phase-shift. A clearer understanding of the intricate …

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Distinct diversity, assembly, and co-occurrence patterns of the prokaryotic microbiome in coral ecosystems of the South China Sea

Wenbin Zhao, Leiran Chen, Huang XiaoYun, Jiwen Liu et autres

Coral reefs are among the most energetic marine ecosystems, taking a place in ecological balance. Microbes participate in the energy exchange in coral ecosystems, which may affect coral resistance and resilience. However, there is still a lack of understanding regarding the microbial …

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Microbial community diversity from nearshore to offshore in the East China Sea

Jian Jin, Xiujie Liu, Wenbin Zhao, Hao Sun et autres

The Pollution Nagasaki (PN) section of the East China Sea (ECS) is a typical area for studying the complex hydrographic dynamics between Changjiang River discharge and Kuroshio, displaying intense variations of environmental gradients from nearshore to offshore. However, the temporal and spatial …

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Diversity of Culturable Bacteria from the Coral Reef Areas in the South China Sea and Their Agar-Degrading Abilities

Mei Liu, Fu Yin, Wenbin Zhao, Peng Tian et autres

The South China Sea (SCS) is abundant in marine microbial resources with high primary productivity, which is crucial for sustaining the coral reef ecosystem and the carbon cycle. Currently, research on the diversity of culturable bacteria in the SCS is relatively extensive, …

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Photobacterium obscurum sp. nov., a marine bacterium isolated from the coast of Qingdao

Hong Wen, Xiaolei Wang, Yalin Yuan, Ronghua Liu et autres

A Gram-stain-negative, facultative anaerobic, rod-shaped strain, named SDRW27T, was isolated from offshore seawater collected near Qingdao. Strain SDRW27T was able to grow at 16–37 °C (optimum, 28 °C), pH 6.0–9.0 (optimum, pH 6.0) and in the presence of 1–7 % (w/v) NaCl …

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Distinct coral environments shape the dynamic of planktonic Vibrio spp.

Wenbin Zhao, Xing Chen, Ronghua Liu, Peng Tian et autres

BACKGROUND: Coral reefs are one of the most biodiverse and productive ecosystems, providing habitat for a vast of species. Reef-building scleractinian corals with a symbiotic microbiome, including bacteria, archaea, viruses and eukaryotic microbes, are referred to coral holobionts. Among them, coral diseases, …

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Vertical dynamics of free-living and particle-associated vibrio communities in the eastern tropical Indian Ocean

Shaodong Zhu, Xiaolei Wang, Wenbin Zhao, Yulin Zhang et autres

Members of the family Vibrionaceae (vibrios) are widely distributed in estuarine, offshore, and marginal seas and perform an important ecological role in the marine organic carbon cycle. Nevertheless, there is little knowledge about whether vibrios play ecological roles in the oligotrophic pelagic …

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Sedimentary Vibrio Blooms in the Xisha Islands May Associate with the 2020 Coral Bleaching Event

Wenbin Zhao, Leiran Chen, Mei Liu, Keyi Huang et autres

spp. were separated by geographical location, which was mainly attributable to the spatial distance and coral species. Overall, this work contributes by providing evidence for the outbreak of coral pathogenic vibrios. The pathogenic mechanism of the dominant species (especially V. harveyi) should …

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Reduced plasma cholesterol in Plasmodium falciparum infection: A meta-analysis

Yao You, Hua Fan, Shenghui Zhang, Siqi Hu et autres

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Vibrio paucivorans sp. nov. and Vibrio qingdaonensis sp. nov., two marine bacteria

Ruihong Guo, Yalin Yuan, Ronghua Liu, Hong Wen et autres

Two Gram-stain-negative, facultatively anaerobic, motile, rod-shaped and flagellated marine bacteria, designated strains DBSS07T and ZSDZ65T, were isolated from the surface sediments of the Bohai sea and Qingdao coastal seawater, respectively. Phylogenetic analysis based on 16S rRNA genes, multilocus sequence analysis (MLSA), phylogenomic …

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