Chunmei Wang

Conventional and genetic associations of BMI with major vascular and non-vascular disease incidence and mortality in a relatively lean Chinese population: U-shaped relationship revisited

Andri Iona, Fiona Bragg, Zammy Fairhurst-Hunter, Iona Y. Millwood et autres

BACKGROUND: Higher body mass index (BMI) is associated with higher incidence of cardiovascular and some non-cardiovascular diseases (CVDs/non-CVDs). However, uncertainty remains about its associations with mortality, particularly at lower BMI levels. METHODS: The prospective China Kadoorie Biobank recruited >512 000 adults aged …

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Nestin Expression and the Survival of Patients With Digestive Tract Cancers: A Systematic Review and Meta-Analysis

Lumi Huang, Lihui Chen, Yiming Wang, Fucheng Zhang et autres

BACKGROUND/AIMS: Several cancers have been associated with poor prognoses based on nestin, a confirmed marker of cancer stem cells. However, there is conflicting evidence regarding the prognostic value of tumor nestin expression in patients with digestive tract cancers. An investigation of the …

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Alcohol consumption and risks of more than 200 diseases in Chinese men

Pek Kei Im, Neil Wright, Ling Yang, Ka Hung Chan et autres

Alcohol consumption accounts for ~3 million annual deaths worldwide, but uncertainty persists about its relationships with many diseases. We investigated the associations of alcohol consumption with 207 diseases in the 12-year China Kadoorie Biobank of >512,000 adults (41% men), including 168,050 genotyped …

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Identification of two molecular subtypes and a novel prognostic model of lung adenocarcinoma based on a cuproptosis-associated gene signature

Jinlin Zhou, Dehe Chen, Shiguo Zhang, Chunmei Wang et autres

Lung adenocarcinoma is the most common subtype of lung cancer clinically, with high mortality and poor prognosis. Cuproptosis present a newly discovered mode of cell death characterized by aggregation of fatty acylated proteins, depletion of iron-sulfur clusterin, triggering of HSP70, and induction …

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Risk factors for deep venous thrombosis in patients with advanced lung cancer after treatment of immune checkpoint inhibitors

LIU Yubingxue, ZENG Xianghua, Ying Tang, Chunmei Wang

Objective To analyze the risk factors for venous thromboembolism event (VTE) in patients with advanced lung cancer treated with immune checkpoint inhibitors (ICIs). Methods A total of 320 patients with advanced lung cancer treated with ICIs at the department of medical oncology …

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Association of heart rate and diabetes among 0.5 million adults in the China Kadoorie biobank: Results from observational and Mendelian randomization analyses

Wenxiu Wang, Jingjia Wang, Jun Lv, Canqing Yu et autres

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Carotid Intima‐Media Thickness but Not Carotid Artery Plaque in Healthy Individuals Is Linked to Lean Body Mass

Matthew G. Arnold, Andrew Brent Linden, Robert Clarke, Canqing Yu et autres

Background Lean body mass has been identified as a key determinant of left ventricular mass and wall thickness. However, the importance of lean body mass or other body‐size measures as normative determinants of carotid intima‐media thickness ( cIMT ), a widely used …

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Genotypes of the Hepatitis C Virus in Infected Patients in Hohhot, China.

Junying Lang, Peng Sun, S.-N. Lu, P. W. Zhao et autres

We wished to identify the existing HCV genotypes in diagnosed cases of infection by the hepatitis C virus in Hohhot (China) to offer basic data for the treatment and prevention of HCV infection in this area. Outpatients and inpatients were recruited from …

The expression of von willebrand factor(vWF) and tissue factor(TF) in ultrasound combined with urokinase and RGDS-targeted microbubbles for recanalization of occluded rabbit femoral artery

Lina Guan, Chunmei Wang, Tuerxunnayi Adi

Objective To explore the express of von willebrand factor(vWF) and tissue factor(TF) in ultrasound combined with urokinase and RGDS-targeted microbubbles for recanalization of occluded rabbit femoral artery. Methods A total of 42 rabbits with platelet-rich thrombi in the femoral artery were randomized …

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Risks and Population Burden of Cardiovascular Diseases Associated with Diabetes in China: A Prospective Study of 0.5 Million Adults

Fiona Bragg, Liming Li, Ling Yang, Canqing Yu et autres

BACKGROUND: In China, diabetes prevalence is rising rapidly, but little is known about the associated risks and population burden of cardiovascular diseases. We assess associations of diabetes with major cardiovascular diseases and the relevance of diabetes duration and other modifiable risk factors …

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Population Pharmacokinetics of Intravenous Infusing Busulfan in Patients Undergoing Hematopoietic Stem Cell Transplantation

SU Han-zhong, Zhang Shan-tang, Sun Zimin, Tang Li-qin et autres

OBJECTIVE To establish a population pharmacokinetic model of intravenous infusing busulfan in HSCT patients,and to explore physiological and pathological factors which may influence the pharmacokinetic parameters. METHODS We have collected clinical history information of 35 patients undergoing HSCT surgery and taking busulfan …

The Serum Profile of Hypercytokinemia Factors Identified in H7N9-Infected Patients can Predict Fatal Outcomes

Jing Guo, Fengming Huang, Jun Liu, Yu Chen et autres

The novel avian origin influenza A (H7N9) virus has caused severe diseases in humans in eastern China since the spring of 2013. Fatal outcomes of H7N9 infections are often attributed to the severe pneumonia and acute respiratory distress syndrome (ARDS). There is …

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