İbrahim Şahin

Clinically relevant depression in patients with type 1 and type 2 diabetes; a nationwide study (TEMD-2 depression)

Bağdagül Yüksel Güler, İbrahim Demirci, Cem Haymana, Esen Akbay et autres

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An overview of immunohistochemistry: Evidence and personal experience

Süleyman Aydın, Suna Aydın, Kader Uğur, İbrahim Şahin et autres

Immunohistochemistry is a tissue-based technique that enables in situ visualization of specific molecules, most commonly proteins or peptides, within preserved cellular and tissue architecture through antigen-antibody specificity. By using labeled antibodies, immunohistochemistry allows spatially resolved and cell type-specific detection of target molecules …

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Association between leptin gene polymorphisms and hematological metabolic parameters in obese Saudi adults

Lamiaa H. Al‐Jamea, Alexander Woodman, Rehab Yusuf Al-Ansari, Fatimah Salem Alayidh et autres

Background Obesity represents a major global public health challenge. However, among the Middle Eastern countries and members of the Gulf Cooperation Council, the Kingdom of Saudi Arabia (K.S.A) has been particularly affected, with prevalence rates exceeding 24.7%. The impact of obesity on …

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Turkish cross-sectional survEy of glycemic and other Metabolic parameters in patients with type 2 Diabetes in 2023: Comparison with 2018 nationwide data (TEMD-2 study)

Alper Sonmez, Cem Haymana, Ibrahim Demirci, Berrin Cetinarslan et autres

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Direct Relationship Between Heparin Binding to Midkine and Pleiotrophin and the Development of Acute Deep Vein Thrombosis

Suna Aydın, İsmail Polat, Kevser Tural, Nurullah Düger et autres

Background/Objectives: The underlying molecular mechanisms of deep vein thrombosis (DVT), which continues to be a major global public health concern, remain unclear. A key component of anticoagulant therapy, heparin (HP) interacts with heparin-binding growth factors including pleiotrophin (PTN) and midkine (MK), both …

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Generative AI for Video Translation: A Scalable Architecture for Multilingual Video Conferencing

Amirkia Rafiei Oskooei, Eren Caglar, İbrahim Şahin, Ayse Kayabay et autres

The real-time deployment of cascaded generative AI pipelines for applications like video translation is constrained by significant system-level challenges. These include the cumulative latency of sequential model inference and the quadratic (O(N2)) computational complexity that renders multi-user video conferencing applications unscalable. This …

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A direct association between suicide and reduced amygdala volume: A retrospective study

Elif Emre, Sevler Yıldız, Gülhan Kılıçarslan, Suna Aydın et autres

Objective The neurological causes of suicide remain poorly understood. This study sought to ascertain whether there is a correlation between amygdala volume and suicidal behavior. Methods This case–control retrospective study included 193 participants—108 healthy controls and 85 individuals with a history of …

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Whisper, Translate, Speak, Sync: Video Translation for Multilingual Video Conferencing Using Generative AI

Amirkia Rafiei Oskooei, Eren Caglar, İbrahim Şahin, Ayse Kayabay et autres

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An overview of ELISA: a review and update on best laboratory practices for quantifying peptides and proteins in biological fluids

Süleyman Aydın, Elif Emre, Kader Uğur, Mustafa Ata Aydin et autres

The enzyme-linked immunosorbent assay (ELISA) detects antigen-antibody interactions by using enzyme-labelled conjugates and enzyme substrates that generate colour changes. This review aims to provide an overview of ELISA, its various types, and its applications in detecting metabolites in biological fluids. The article …

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Some animal protein antigens identified in cells of two plant species

İbrahim Şahin, Yesari Eröksüz, Kader Uğur, Canan Akdeniz İncili et autres

Abstract Objectives It has been recently reported that immune activity of some animal peptides/proteins has been found in some plants. In this study, the presence of immune reactivity of alarin, asprosin, paraoxonase, elabela, glucagon, and nesfatin-1 like molecules was investigated in two …

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Effects of irisin and exercise on adropin and betatrophin in a new metabolic syndrome model

Suna Aydın, Faruk Kılınç, Kader Uğur, Mustafa Ata Aydin et autres

Metabolic syndrome (MetS) is a prevalent public health problem. Uric acid (UA) is increased by MetS. We investigated whether administration of UA and 10% fructose (F) would accelerate MetS formation and we also determined the effects of irisin and exercise. We used …

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Betatrophin, elabela, asprosin, glucagon and subfatin peptides in breast tissue, blood and milk in gestational diabetes

Adem Yavuz, Mustafa Ata Aydin, Kader Uğur, Suna Aydın et autres

We investigated the presence of asprosin (ASP), betatrophin, elabela (ELA), glucagon and subfatin (SUB) in the milk of mothers with gestational diabetes mellitus (GDM) and compared their levels with blood levels. We also investigated whether these peptides are synthesized by the breast. …

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